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> Protein (NX_P34931)
Protein (NX_P34931)
Protein
Gene SymbolHSPA1L to neXtProt (NX_P34931)
DescriptionHeat shock 70 kDa protein 1-like
Chromosome6
Location6p21.33 (31777396 ~ 31783437) to Ensembl
Sequene Features : Isoforms 1, Variants 108, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein targeting to mitochondrion
.regulation of cellular response to heat
.protein refolding
  + 3 more...
.unfolded protein binding
.ATP binding
.blood microparticle
.cell body
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 108 1
2014-09-19protein level
1 86 1
2014-05-27protein level
1 86 9
2014-02-25protein level
1 37 9
2013-12-09protein level
1 14 9
2013-11-01protein level
1 14 6
2013-09-12protein level
1 14 6
2013-08-17protein level
1 14 6
2013-07-15protein level
1 14 5
2013-06-11protein level
1 14 5
2013-02-12protein level
1 14 5
2012-12-20protein level
1 13 5
2012-10-30protein level
1 19 5
2012-10-07protein level
1 19 5
2012-08-24protein level
1 19 5
2012-07-28protein level
1 19 5
2012-06-08protein level
1 27 5
2012-05-07protein level
1 27 5
2012-04-10protein level
1 27 5
2012-01-13protein level
1 15 5
2011-12-20protein level
1 15 5
2011-11-11protein level
1 15 3
2011-08-23protein level
1 19 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P34931-1
16 0 12 70331.1197
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-354912,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain9
connective tissue20
eye14
heart11
intestine4
kidney9
lung8
mammary gland13
pituitary gland60
prostate5
spleen18
testis85
uterus8
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor10
chondrosarcoma24
gastrointestinal tumor8
germ cell tumor7
glioma27
head and neck tumor7
kidney tumor14
lung tumor9
prostate cancer9
Developmental Stage
TissuesTPM*
adult2
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.9
appendix1.7
cerebral cortex2.4
colon1.1
gallbladder1.1
heart muscle1.5
kidney1.7
lung1.4
lymph node1.9
ovary4.4
placenta1.3
prostate1.6
salivary gland1.2
skin1
spleen2.1
stomach1.3
testis51.9
thyroid gland2.7
urinary bladder1.2
Tissues
TissuesExpression level
adrenal glandLow
bronchusLow
cervix, uterineLow
fallopian tubeLow
nasopharynxLow
prostateLow
skin 1Low
skin 2Low
testisHigh
tonsilLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*140559, gene) Heat-shock 70-kd protein-like 1; HSPA1LOMIM


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