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> Protein (NX_P34932)
Protein (NX_P34932)
Protein
Gene SymbolHSPA4 to neXtProt (NX_P34932)
DescriptionHeat shock 70 kDa protein 4
Chromosome5
Location5q31.1 (132387654 ~ 132442141) to Ensembl
Sequene Features : Isoforms 2, Variants 88, PTMs 39 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.chaperone-mediated protein complex assembly
.protein import into mitochondrial outer membrane
.response to unfolded protein
.ATP binding .extracellular exosome
.cytosol
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 88 39
2014-09-19protein level
1 74 39
2014-05-27protein level
1 74 42
2014-02-25protein level
1 74 40
2013-12-09protein level
1 59 40
2013-11-01protein level
1 56 24
2013-09-12protein level
1 56 24
2013-08-17protein level
1 56 24
2013-07-15protein level
1 39 12
2013-06-11protein level
1 39 12
2013-02-12protein level
1 19 11
2012-12-20protein level
1 19 11
2012-10-30protein level
1 28 11
2012-10-07protein level
1 28 11
2012-08-24protein level
1 28 11
2012-07-28protein level
1 28 11
2012-06-08protein level
1 35 11
2012-05-07protein level
1 30 11
2012-04-10protein level
1 30 11
2012-01-13protein level
1 14 11
2011-12-20protein level
1 14 11
2011-11-11protein level
1 14 10
2011-08-23protein level
1 14 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P34932-1
32 6 3 94270.9746
NX_P34932-2
1 6 0 15679.5693
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356933,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
2 EBI-356933,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites200
blood24
bone111
bone marrow61
brain45
cervix123
connective tissue53
embryonic tissue164
esophagus99
eye81
heart33
intestine112
kidney42
liver38
lung65
lymph90
lymph node55
mammary gland152
mouth196
muscle75
nerve64
ovary88
pancreas56
pharynx49
placenta77
prostate79
salivary gland148
skin185
spleen18
stomach438
testis73
thymus37
thyroid21
tonsil58
trachea19
uterus94
Health State
TissuesTPM*
normal60
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor214
cervical tumor173
chondrosarcoma156
colorectal tumor159
esophageal tumor115
gastrointestinal tumor455
germ cell tumor132
glioma18
head and neck tumor104
kidney tumor72
leukemia31
liver tumor62
lung tumor68
lymphoma96
non-neoplasia72
ovarian tumor91
pancreatic tumor57
primitive neuroectodermal tumor of the CNS55
prostate cancer86
retinoblastoma150
skin tumor279
soft tissue/muscle tissue tumor103
uterine tumor122
Developmental Stage
TissuesTPM*
adult118
embryoid body85
blastocyst211
fetus50
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.6
adrenal gland33.8
appendix32.7
bone marrow21.7
cerebral cortex36.1
colon30.6
duodenum19.3
esophagus43.5
gallbladder23.9
heart muscle36.3
kidney34.7
liver26.4
lung22
lymph node37.8
ovary19.2
pancreas11.4
placenta32.5
prostate23.5
salivary gland17.8
skin21.7
small intestine18.9
spleen25
stomach23.5
testis49.5
thyroid gland33.1
urinary bladder33.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601113, gene) Heat-shock 70-kd protein 4; HSPA4OMIM


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