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> Protein (NX_P35080)
Protein (NX_P35080)
Protein
Gene SymbolPFN2 to neXtProt (NX_P35080)
DescriptionProfilin-2
Chromosome3
Location3q25.1 (149682691 ~ 149768575) to Ensembl
Sequene Features : Isoforms 2, Variants 19, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of synaptic vesicle exocytosis
.positive regulation of protein stabilization
.negative regulation of ruffle assembly
  + 8 more...
.phosphatidylinositol-4,5-bisphosphate binding
.actin monomer binding
.adenyl-nucleotide exchange factor activity
.extracellular exosome
.terminal bouton
.cytoskeleton
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 19 3
2014-09-19protein level
2 11 3
2014-05-27protein level
2 11 3
2014-02-25protein level
2 10 2
2013-12-09protein level
2 9 2
2013-11-01protein level
2 9 1
2013-09-12protein level
2 9 2
2013-08-17protein level
2 9 2
2013-07-15protein level
2 9 2
2013-06-11protein level
2 9 2
2013-02-12protein level
2 2 5
2012-12-20protein level
2 2 5
2012-10-30protein level
2 2 5
2012-10-07protein level
2 2 3
2012-08-24protein level
2 0 3
2012-07-28protein level
2 0 3
2012-06-08protein level
2 1 3
2012-05-07protein level
2 5 3
2012-04-10protein level
2 5 3
2012-01-13protein level
2 4 3
2011-12-20protein level
2 4 3
2011-11-11protein level
2 4 3
2011-08-23protein level
2 4 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35080-1
2 5 0 15036.224
NX_P35080-2
3 5 0 15078.3569
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-473138,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-473138,EBI-709973 GOLGB1  
  .Golgi organization .poly(A) RNA binding .integral component of membrane
.membrane
.cis-Golgi network
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder167
blood32
bone27
bone marrow41
brain519
cervix123
connective tissue80
ear62
embryonic tissue244
esophagus198
eye162
heart100
intestine56
kidney118
larynx42
liver73
lung86
lymph node11
mammary gland59
muscle263
nerve64
ovary78
pancreas229
parathyroid145
pituitary gland302
placenta88
prostate94
skin137
spleen37
stomach62
testis121
trachea38
uterus99
vascular77
Health State
TissuesTPM*
normal176
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor86
chondrosarcoma48
colorectal tumor35
esophageal tumor115
gastrointestinal tumor59
germ cell tumor254
glioma186
head and neck tumor14
kidney tumor275
leukemia63
liver tumor93
lung tumor126
non-neoplasia186
ovarian tumor78
pancreatic tumor199
primitive neuroectodermal tumor of the CNS527
prostate cancer77
retinoblastoma150
skin tumor95
soft tissue/muscle tissue tumor119
uterine tumor99
Developmental Stage
TissuesTPM*
adult114
embryoid body228
blastocyst179
neonate32
fetus157
infant1488
juvenile359
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25
adrenal gland40.6
appendix20.7
bone marrow1
cerebral cortex215.4
colon30
duodenum21.4
esophagus29.8
gallbladder43.1
heart muscle39.6
kidney93.6
liver14.7
lung19.3
lymph node6.4
ovary61.1
pancreas17.7
placenta23.5
prostate66.1
salivary gland35.2
skin5.1
small intestine30.2
spleen15.8
stomach18.6
testis28.2
thyroid gland95
urinary bladder56.7
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
breastLow
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lungMedium
nasopharynxHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176590, gene) Profilin 2; PFN2OMIM


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