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> Protein (NX_P35226)
Protein (NX_P35226)
Protein
Gene SymbolBMI1 to neXtProt (NX_P35226)
DescriptionPolycomb complex protein BMI-1
Chromosome10
Location10p12.2 (22610140 ~ 22620413) to Ensembl
Sequene Features : Isoforms 1, Variants 40, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of ubiquitin-protein transferase activity
.positive regulation of fibroblast proliferation
.cellular protein metabolic process
  + 8 more...
.RING-like zinc finger domain binding
.zinc ion binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 40 3
2014-09-19protein level
1 28 3
2014-05-27protein level
1 28 4
2014-02-25protein level
1 28 4
2013-12-09protein level
1 24 4
2013-11-01protein level
1 24 3
2013-09-12protein level
1 24 3
2013-08-17protein level
1 24 3
2013-07-15protein level
1 18 3
2013-06-11protein level
1 18 3
2013-02-12protein level
1 5 3
2012-12-20protein level
1 5 3
2012-10-30protein level
1 6 3
2012-10-07protein level
1 6 3
2012-08-24protein level
1 6 3
2012-07-28protein level
1 6 3
2012-06-08protein level
1 8 3
2012-05-07protein level
1 4 3
2012-04-10protein level
1 4 3
2012-01-13protein level
1 5 3
2011-12-20protein level
1 5 3
2011-11-11protein level
1 5 3
2011-08-23protein level
1 5 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35226-1
12 0 1 36925.258
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2341576,EBI-722425 CBX4  
  .negative regulation of transcription, DNA-templated
.cellular protein metabolic process
.post-translational protein modification
  + 5 more...
.transcription regulatory region DNA binding
.SUMO binding
.enzyme binding
  + 5 more...
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 2 more...
2 EBI-2341576,EBI-3951758 CBX6  
  .chromatin modification
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.single-stranded RNA binding .PcG protein complex
.nucleoplasm
.nucleus
.heterochromatin
3 EBI-2341576,EBI-3923843 CBX7  
  .sebaceous gland development
.chromatin modification
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.single-stranded RNA binding
.chromatin binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 4 more...
4 EBI-2341576,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
5 EBI-2341576,EBI-306876 USP11  
  .regulation of proteasomal protein catabolic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
.protein deubiquitination
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.cytoplasm
.nucleus
6 EBI-2341576,EBI-696162 PTEN  
  .positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
  + 91 more...
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
  + 10 more...
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
  + 12 more...
7 EBI-2341576,EBI-752313 RING1  
  .camera-type eye morphogenesis
.negative regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.chromatin binding
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 4 more...
8 EBI-2341576,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
9 EBI-2341576,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
10 EBI-2341576,EBI-722416 RNF2  
  .cellular protein metabolic process
.post-translational protein modification
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 8 more...
.RING-like zinc finger domain binding
.ligase activity
.zinc ion binding
  + 2 more...
.MLL1 complex
.PRC1 complex
.PcG protein complex
  + 6 more...
11 EBI-2341576,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
12 EBI-2341576,EBI-373380 VPS11  
  .positive regulation of protein targeting to mitochondrion
.vesicle-mediated transport
.intracellular protein transport
.syntaxin binding
.zinc ion binding
.nucleotide binding
.late endosome membrane
.HOPS complex
.endocytic vesicle
  + 4 more...
13 EBI-2341576,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder33
blood16
bone69
bone marrow41
brain5
connective tissue40
embryonic tissue4
esophagus99
eye47
heart22
intestine25
kidney47
liver58
lung47
lymph node33
mammary gland59
mouth45
muscle18
ovary88
pancreas42
parathyroid291
pharynx24
pituitary gland121
placenta38
prostate31
salivary gland98
skin37
spleen18
stomach20
testis45
thymus12
thyroid21
trachea19
uterus30
vascular58
Health State
TissuesTPM*
normal4
adrenal tumor158
bladder carcinoma170
breast (mammary gland) tumor42
chondrosarcoma36
colorectal tumor35
esophageal tumor115
gastrointestinal tumor25
germ cell tumor26
glioma9
head and neck tumor29
kidney tumor14
leukemia10
liver tumor93
lymphoma27
non-neoplasia41
ovarian tumor13
pancreatic tumor57
primitive neuroectodermal tumor of the CNS15
prostate cancer28
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult3
blastocyst16
neonate32
fetus3
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.4
adrenal gland34.2
appendix28.9
bone marrow21.8
cerebral cortex30.5
colon22.3
duodenum22.4
esophagus23.9
gallbladder28.1
heart muscle18.4
kidney26.3
liver18.7
lung28.6
lymph node33
ovary22.8
pancreas14.7
placenta34.1
prostate37.9
salivary gland18
skin16.3
small intestine20.4
spleen39.3
stomach27.1
testis42.4
thyroid gland28.4
urinary bladder29
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumLow
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumLow
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Low
small intestineLow
smooth muscleLow
soft tissue 1High
soft tissue 2Medium
spleenMedium
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164831, gene) Leukemia viral bmi-1 oncogene, mouse, homolog of; BMI1OMIM


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