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> Protein (NX_P35227)
Protein (NX_P35227)
Protein
Gene SymbolPCGF2 to neXtProt (NX_P35227)
DescriptionPolycomb group RING finger protein 2
Chromosome17
Location17q12 (36890150 ~ 36906070) to Ensembl
Sequene Features : Isoforms 1, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of apoptotic signaling pathway
.cellular response to hydrogen peroxide
.embryonic skeletal system morphogenesis
  + 8 more...
.zinc ion binding
.ubiquitin-protein transferase activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.PRC1 complex
.PcG protein complex
.nuclear body
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 30 1
2014-09-19protein level
1 23 1
2014-05-27protein level
1 23 2
2014-02-25protein level
1 23 2
2013-12-09protein level
1 15 2
2013-11-01protein level
1 14 1
2013-09-12protein level
1 14 1
2013-08-17protein level
1 14 1
2013-07-15protein level
1 8 1
2013-06-11protein level
1 8 1
2013-02-12protein level
1 4 1
2012-12-20protein level
1 4 1
2012-10-30protein level
1 6 1
2012-10-07protein level
1 6 1
2012-08-24protein level
1 4 1
2012-07-28protein level
1 4 1
2012-06-08protein level
1 4 1
2012-05-07protein level
1 4 1
2012-04-10protein level
1 4 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35227-1
13 0 1 37763.7557
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2129767,EBI-3923843 CBX7  
  .sebaceous gland development
.chromatin modification
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.single-stranded RNA binding
.chromatin binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 4 more...
2 EBI-2129767,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-2129767,EBI-306876 USP11  
  .regulation of proteasomal protein catabolic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
.protein deubiquitination
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.cytoplasm
.nucleus
4 EBI-2129767,EBI-752313 RING1  
  .camera-type eye morphogenesis
.negative regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.chromatin binding
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 4 more...
5 EBI-2129767,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
6 EBI-2129767,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
7 EBI-2129767,EBI-722416 RNF2  
  .cellular protein metabolic process
.post-translational protein modification
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 8 more...
.RING-like zinc finger domain binding
.ligase activity
.zinc ion binding
  + 2 more...
.MLL1 complex
.PRC1 complex
.PcG protein complex
  + 6 more...
8 EBI-2129767,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder33
blood8
bone97
bone marrow41
brain29
cervix61
connective tissue33
embryonic tissue32
esophagus49
eye129
heart55
intestine47
kidney61
liver19
lung50
lymph22
mammary gland46
muscle56
ovary137
pancreas28
parathyroid97
placenta21
prostate63
skin4
spleen18
testis18
thyroid21
Health State
TissuesTPM*
normal38
bladder carcinoma113
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor25
germ cell tumor15
glioma27
kidney tumor29
liver tumor41
lung tumor38
lymphoma27
non-neoplasia20
ovarian tumor118
pancreatic tumor38
primitive neuroectodermal tumor of the CNS62
prostate cancer38
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult53
embryoid body14
fetus28
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.4
adrenal gland13.3
appendix6.8
cerebral cortex10.7
colon7.7
duodenum4.9
esophagus6.8
gallbladder13.7
heart muscle11.9
kidney24.2
liver3.1
lung18.1
lymph node3.8
ovary20.4
pancreas5.4
placenta16.1
prostate16
salivary gland13.1
skin8.6
small intestine7.8
spleen13.1
stomach11.6
testis8
thyroid gland18.4
urinary bladder12.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600346, gene) Polycomb group ring finger protein 2; PCGF2OMIM


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