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> Protein (NX_P35568)
Protein (NX_P35568)
Protein
Gene SymbolIRS1 to neXtProt (NX_P35568)
DescriptionInsulin receptor substrate 1
Chromosome2
Location2q36.3 (227596033 ~ 227664475) to Ensembl
Sequene Features : Isoforms 1, Variants 206, PTMs 28 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of glucose import in response to insulin stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.phosphatidylinositol-mediated signaling
  + 29 more...
.phosphatidylinositol 3-kinase binding
.SH2 domain binding
.insulin-like growth factor receptor binding
  + 4 more...
.intracellular membrane-bounded organelle
.ciliary basal body
.caveola
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 206 28
2014-09-19protein level
1 167 28
2014-05-27protein level
1 167 28
2014-02-25protein level
1 167 28
2013-12-09protein level
1 128 28
2013-11-01protein level
1 124 28
2013-09-12protein level
1 124 31
2013-08-17protein level
1 124 31
2013-07-15protein level
1 103 31
2013-06-11protein level
1 103 31
2013-02-12protein level
1 57 26
2012-12-20protein level
1 56 26
2012-10-30protein level
1 62 26
2012-10-07protein level
1 62 26
2012-08-24protein level
1 42 26
2012-07-28protein level
1 41 26
2012-06-08protein level
1 45 26
2012-05-07protein level
1 45 26
2012-04-10protein level
1 45 26
2012-01-13protein level
1 28 26
2011-12-20protein level
1 28 26
2011-11-11protein level
1 28 26
2011-08-23protein level
1 28 24
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35568-1
54 0 0 131508.4923
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-517592,EBI-702336 BCAR3  
  .response to drug
.positive regulation of peptidyl-serine phosphorylation
.small GTPase mediated signal transduction
  + 2 more...
.guanyl-nucleotide exchange factor activity .N/A
2 EBI-517592,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-517592,EBI-475899 INSR  
  .cellular response to growth factor stimulus
.positive regulation of respiratory burst
.positive regulation of protein kinase B signaling
  + 31 more...
.PTB domain binding
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.extracellular exosome
.receptor complex
.intracellular membrane-bounded organelle
  + 6 more...
4 EBI-517592,EBI-81531 PABPC1  
  .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
5 EBI-517592,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
6 EBI-517592,EBI-2116585 PIK3CA  
  .negative regulation of anoikis
.regulation of genetic imprinting
.negative regulation of fibroblast apoptotic process
  + 36 more...
.phosphatidylinositol-4,5-bisphosphate 3-kinase activity
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.phosphatidylinositol 3-kinase activity
  + 5 more...
.lamellipodium
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 3 more...
7 EBI-517592,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
8 EBI-517592,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
bone27
brain11
connective tissue335
ear62
embryonic tissue61
eye23
heart11
intestine17
kidney4
larynx42
liver14
lung26
mammary gland39
muscle37
nerve64
ovary39
pancreas56
pharynx24
placenta14
prostate31
skin14
stomach31
testis4
thymus12
thyroid64
trachea19
uterus34
Health State
TissuesTPM*
normal23
breast (mammary gland) tumor42
chondrosarcoma72
gastrointestinal tumor33
germ cell tumor18
glioma27
head and neck tumor22
liver tumor41
lung tumor9
ovarian tumor52
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor399
uterine tumor11
Developmental Stage
TissuesTPM*
adult47
embryoid body114
blastocyst65
fetus28
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.6
adrenal gland13
appendix3
cerebral cortex1.7
colon4.2
duodenum3.9
esophagus4.4
gallbladder6.1
heart muscle4.7
kidney4.7
liver6.7
lung3.9
lymph node1.8
ovary14.2
pancreas1.6
placenta8.4
prostate6.7
salivary gland1.8
skin2.6
small intestine1.8
spleen2.3
stomach5.2
testis1.2
thyroid gland19.9
urinary bladder9.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#125853, phenotype) Diabetes mellitus, noninsulin-dependent; NIDDMOMIM
2(+147545, gene/phenotype) Insulin receptor substrate 1; IRS1OMIM


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