Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P35579)
Protein (NX_P35579)
Protein
Gene SymbolMYH9 to neXtProt (NX_P35579)
DescriptionMyosin-9
Chromosome22
Location22q12.3 (36677327 ~ 36784063) to Ensembl
Sequene Features : Isoforms 2, Variants 280, PTMs 58 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein processing in phagocytic vesicle
.negative regulation of actin filament severing
.platelet aggregation
  + 24 more...
.actin filament binding
.poly(A) RNA binding
.ADP binding
  + 9 more...
.myosin II filament
.extracellular exosome
.protein complex
  + 18 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 280 58
2014-09-19protein level
2 221 58
2014-05-27protein level
2 221 64
2014-02-25protein level
2 221 56
2013-12-09protein level
2 186 57
2013-11-01protein level
2 180 37
2013-09-12protein level
2 180 38
2013-08-17protein level
2 180 38
2013-07-15protein level
2 118 26
2013-06-11protein level
2 118 26
2013-02-12protein level
2 69 34
2012-12-20protein level
2 70 34
2012-10-30protein level
2 73 34
2012-10-07protein level
2 73 24
2012-08-24protein level
2 52 24
2012-07-28protein level
2 52 24
2012-06-08protein level
2 62 24
2012-05-07protein level
2 62 24
2012-04-10protein level
2 62 24
2012-01-13protein level
2 42 24
2011-12-20protein level
2 42 24
2011-11-11protein level
2 42 22
2011-08-23protein level
2 42 22
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35579-1
25 49 17 226390.935
NX_P35579-2
1 49 13 159763.6015
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-350338,EBI-592789 MEN1  
  .maternal process involved in female pregnancy
.palate development
.negative regulation of telomerase activity
  + 37 more...
.R-SMAD binding
.protein N-terminus binding
.transcription regulatory region DNA binding
  + 6 more...
.protein complex
.histone methyltransferase complex
.cleavage furrow
  + 6 more...
2 EBI-350338,EBI-346967 NCL  
  .positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.angiogenesis
.poly(A) RNA binding
.identical protein binding
.telomeric DNA binding
  + 3 more...
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
.ribonucleoprotein complex
  + 5 more...
3 EBI-350338,EBI-489411 CXCR4  
  .cellular response to cytokine stimulus
.chemokine-mediated signaling pathway
.neural precursor cell proliferation
  + 24 more...
.ubiquitin binding
.myosin light chain binding
.ubiquitin protein ligase binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.cell leading edge
  + 11 more...
4 EBI-350338,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland91
bladder435
blood548
bone488
bone marrow164
brain73
cervix185
connective tissue140
ear186
embryonic tissue624
esophagus347
eye158
heart134
intestine793
kidney237
larynx2215
liver311
lung358
lymph338
lymph node267
mammary gland595
mouth90
muscle131
nerve514
ovary206
pancreas215
pharynx220
placenta208
prostate242
salivary gland345
skin370
spleen449
stomach386
testis39
thymus87
thyroid815
tonsil587
trachea38
uterus370
vascular154
Health State
TissuesTPM*
normal200
adrenal tumor237
bladder carcinoma625
breast (mammary gland) tumor515
cervical tumor115
chondrosarcoma531
colorectal tumor1439
esophageal tumor405
gastrointestinal tumor320
germ cell tumor136
glioma205
head and neck tumor747
kidney tumor595
leukemia687
liver tumor604
lung tumor554
lymphoma249
non-neoplasia82
ovarian tumor249
pancreatic tumor419
primitive neuroectodermal tumor of the CNS118
prostate cancer337
retinoblastoma43
skin tumor287
soft tissue/muscle tissue tumor335
uterine tumor554
Developmental Stage
TissuesTPM*
adult465
embryoid body1271
blastocyst406
fetus89
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue157.9
adrenal gland55.6
appendix150.1
bone marrow138.9
cerebral cortex29.9
colon122.2
duodenum83.5
esophagus95.1
gallbladder133.7
heart muscle61.4
kidney88.6
liver64.6
lung178.4
lymph node139.2
ovary63.4
pancreas64.3
placenta134
prostate81.4
salivary gland119
skin85
small intestine96.9
spleen202.8
stomach97.7
testis42.5
thyroid gland83.3
urinary bladder115.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusLow
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderMedium
kidneyHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxLow
ovaryMedium
pancreasLow
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineLow
soft tissue 1Low
soft tissue 2Low
stomach 1Low
stomach 2Low
testisLow
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#153640, phenotype) Fechtner syndrome; FTNSOMIM
2(#153650, phenotype) Epstein syndromeOMIM
3(#155100, phenotype) May-hegglin anomaly; MHAOMIM
4(*160775, gene) Myosin, heavy chain 9, nonmuscle; MYH9OMIM
5(#600208, phenotype) Macrothrombocytopenia and progressive sensorineural deafnessOMIM
6(#603622, phenotype) Deafness, autosomal dominant 17; DFNA17OMIM
7(#605249, phenotype) Sebastian syndrome; SBSOMIM
8anaplastic large-cell lymphoma;Deafness;autosomal dominant 17;Epstein syndrome;Fechtner syndrome;May-Hegglin anomaly;Sebastian syndromeCGP


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center