Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P35609)
Protein (NX_P35609)
Protein
Gene SymbolACTN2 to neXtProt (NX_P35609)
DescriptionAlpha-actinin-2
Chromosome1
Location1q43 (236849754 ~ 236927931) to Ensembl
Sequene Features : Isoforms 2, Variants 189, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein localization to cell surface
.positive regulation of potassium ion transmembrane transporter activity
.negative regulation of potassium ion transmembrane transporter activity
  + 13 more...
.titin Z domain binding
.FATZ binding
.protein dimerization activity
  + 8 more...
.extracellular exosome
.dendritic spine
.pseudopodium
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 189 0
2014-09-19protein level
2 145 0
2014-05-27protein level
1 144 5
2014-02-25protein level
1 144 5
2013-12-09protein level
1 132 5
2013-11-01protein level
1 125 4
2013-09-12protein level
1 125 5
2013-08-17protein level
1 125 5
2013-07-15protein level
1 85 4
2013-06-11protein level
1 85 4
2013-02-12protein level
1 27 3
2012-12-20protein level
1 26 3
2012-10-30protein level
1 28 3
2012-10-07protein level
1 28 3
2012-08-24protein level
1 26 3
2012-07-28protein level
1 26 3
2012-06-08protein level
1 26 3
2012-05-07protein level
1 16 3
2012-04-10protein level
1 16 3
2012-01-13protein level
1 9 3
2011-12-20protein level
1 9 3
2011-11-11protein level
1 9 1
2011-08-23protein level
1 9 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35609-1
1 33 16 103787.9834
NX_P35609-2
2 33 15 103854.0413
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77797,EBI-2799016 DYSF  
  .vesicle fusion
.plasma membrane repair
.calcium-dependent phospholipid binding
.phospholipid binding
.calcium ion binding
.extracellular exosome
.sarcolemma
.cytoplasmic vesicle membrane
  + 8 more...
2 EBI-77797,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
3 EBI-77797,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
4 EBI-77797,EBI-525291 ANG  
  .RNA phosphodiester bond hydrolysis
.nucleic acid phosphodiester bond hydrolysis
.positive regulation of protein secretion
  + 19 more...
.protein homodimerization activity
.peptide binding
.rRNA binding
  + 7 more...
.extracellular exosome
.neuronal cell body
.angiogenin-PRI complex
  + 5 more...
5 EBI-77797,EBI-6426121 KCNA5  
  .positive regulation of myoblast proliferation
.positive regulation of G1/S transition of mitotic cell cycle
.regulation of heart rate by cardiac conduction
  + 18 more...
.scaffold protein binding
.voltage-gated potassium channel activity involved in SA node cell action potential repolarization
.voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
  + 6 more...
.perinuclear region of cytoplasm
.intracellular canaliculus
.membrane raft
  + 8 more...
6 EBI-77797,EBI-751145 SP100  
  .negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
7 EBI-77797,EBI-5357134 MYOM2  
  .muscle contraction .structural constituent of muscle .myosin filament
.M band
.mitochondrion
8 EBI-77797,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
9 EBI-77797,EBI-5658852 PDLIM3  
  .heart development
.actin filament organization
.structural constituent of muscle
.zinc ion binding
.Z disc
.actin cytoskeleton
.cytoplasm
10 EBI-77797,EBI-5666615 BRMS1L  
  .regulation of growth
.histone deacetylation
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.histone deacetylase binding .Sin3-type complex
11 EBI-77797,EBI-2555563 MICALL2  
  .positive regulation of protein targeting to mitochondrion
.tight junction assembly
.substrate adhesion-dependent cell spreading
  + 5 more...
.actin filament binding
.filamin binding
.zinc ion binding
.recycling endosome
.neuron projection
.tight junction
  + 4 more...
12 EBI-77797,EBI-681210 TTN  
  .cardiac muscle contraction
.cardiac muscle tissue morphogenesis
.cardiac myofibril assembly
  + 18 more...
.structural molecule activity conferring elasticity
.muscle alpha-actinin binding
.actin filament binding
  + 13 more...
.extracellular exosome
.I band
.M band
  + 5 more...
13 EBI-77797,EBI-746712 MYOZ2  
  .N/A .telethonin binding
.protein phosphatase 2B binding
.Z disc
.sarcomere
.actin cytoskeleton
14 EBI-77797,EBI-529989 DISC1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of synapse maturation
.canonical Wnt signaling pathway
  + 10 more...
.N/A .postsynaptic membrane
.ciliary basal body
.cell junction
  + 4 more...
15 EBI-77797,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain39
connective tissue13
embryonic tissue18
eye19
heart949
intestine4
kidney23
larynx681
liver9
lung23
mouth226
muscle639
nerve193
pharynx24
prostate10
testis4
thyroid21
trachea19
vascular38
Health State
TissuesTPM*
normal67
chondrosarcoma12
germ cell tumor3
glioma18
head and neck tumor156
kidney tumor58
non-neoplasia20
primitive neuroectodermal tumor of the CNS15
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult43
fetus141
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex27.3
esophagus36.1
gallbladder3
heart muscle990.1
lung5.9
ovary1.1
prostate34.6
small intestine1
testis6.6
urinary bladder4.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*102573, gene) Actinin, alpha-2; ACTN2OMIM
2(#192600, phenotype) Cardiomyopathy, familial hypertrophic, 1; CMH1OMIM
3(#612158, phenotype) Cardiomyopathy, dilated, 1aa; CMD1AAOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center