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> Protein (NX_P35638)
Protein (NX_P35638)
Protein
Gene SymbolDDIT3 to neXtProt (NX_P35638)
DescriptionDNA damage-inducible transcript 3 protein
Chromosome12
Location12q13.3 (57910371 ~ 57914300) to Ensembl
Sequene Features : Isoforms 2, Variants 32, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of determination of dorsal identity
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  + 32 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.leucine zipper domain binding
  + 8 more...
.CHOP-ATF3 complex
.CHOP-ATF4 complex
.CHOP-C/EBP complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 32 6
2014-09-19protein level
2 23 6
2014-05-27protein level
2 23 6
2014-02-25protein level
2 23 6
2013-12-09protein level
2 22 6
2013-11-01protein level
2 22 6
2013-09-12protein level
2 22 6
2013-08-17protein level
2 22 6
2013-07-15protein level
1 15 6
2013-06-11protein level
1 15 6
2013-02-12protein level
1 10 6
2012-12-20protein level
1 10 6
2012-10-30transcript level
1 9 0
2012-10-07transcript level
1 9 0
2012-08-24transcript level
1 2 0
2012-07-28transcript level
1 2 0
2012-06-08transcript level
1 3 0
2012-05-07transcript level
1 3 0
2012-04-10transcript level
1 3 0
2012-01-13transcript level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35638-1
1 3 0 19163.2082
NX_P35638-2
1 3 0 21686.4007
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10173632,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-10173632,EBI-749483 SNAPC5  
  .gene expression
.transcription initiation from RNA polymerase III promoter
.transcription from RNA polymerase III promoter
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity .nucleolus
.nucleoplasm
.nucleus
3 EBI-10173632,EBI-3893419 FOSL2  
  .response to cAMP
.response to corticosterone
.positive regulation of fibroblast proliferation
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.double-stranded DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
4 EBI-10173632,EBI-739899 ZBTB25  
  .gene expression
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
5 EBI-10173632,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
6 EBI-10173632,EBI-740209 CEBPG  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of DNA repair
  + 10 more...
.protein heterodimerization activity
.sequence-specific DNA binding
.transcription factor binding
  + 3 more...
.nucleoplasm
.nucleus
7 EBI-10173632,EBI-10241443 CCDC153  
  .N/A .N/A .N/A
8 EBI-10173632,EBI-740660 ZC3H14  
  .negative regulation of mRNA polyadenylation
.regulation of mRNA stability
.metal ion binding
.poly(A) RNA binding
.poly(A) binding
.nuclear speck
.cytoplasm
.nucleolus
  + 2 more...
9 EBI-10173632,EBI-6598631 EMSY  
  .chromatin modification
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA repair
.N/A .nucleoplasm
10 EBI-10173632,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
11 EBI-10173632,EBI-742664 HSD17B14  
  .steroid catabolic process .testosterone 17-beta-dehydrogenase (NADP+) activity
.estradiol 17-beta-dehydrogenase activity
.cytosol
12 EBI-10173632,EBI-10312707 BATF3  
  .dendritic cell differentiation
.myeloid dendritic cell differentiation
.response to virus
  + 2 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
13 EBI-10173632,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites50
blood98
bone97
bone marrow143
brain24
cervix41
connective tissue40
embryonic tissue18
esophagus99
eye158
heart22
intestine94
kidney52
liver92
lung35
lymph45
lymph node66
mammary gland39
muscle235
ovary39
pancreas42
parathyroid97
pharynx24
pituitary gland181
placenta45
prostate31
skin23
stomach271
testis22
thymus62
thyroid64
trachea19
uterus25
vascular19
Health State
TissuesTPM*
normal55
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma84
colorectal tumor151
esophageal tumor115
gastrointestinal tumor42
germ cell tumor18
glioma18
head and neck tumor22
kidney tumor58
leukemia42
liver tumor20
lung tumor38
lymphoma27
non-neoplasia10
ovarian tumor26
pancreatic tumor66
primitive neuroectodermal tumor of the CNS23
prostate cancer28
skin tumor15
soft tissue/muscle tissue tumor175
uterine tumor33
Developmental Stage
TissuesTPM*
adult59
embryoid body42
blastocyst16
neonate32
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.2
adrenal gland46.1
appendix16.4
bone marrow102.5
cerebral cortex24.6
colon18.6
duodenum15.8
esophagus15.9
gallbladder33.2
heart muscle31.5
kidney31.3
liver31.4
lung22.2
lymph node16.9
ovary46.4
pancreas11.1
placenta41.1
prostate25.7
salivary gland17.4
skin13.1
small intestine14.8
spleen18.4
stomach22.8
testis27.2
thyroid gland174.8
urinary bladder22.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*126337, gene) Dna damage-inducible transcript 3; DDIT3OMIM
2(#613488, phenotype) Myxoid liposarcomaOMIM
3liposarcomaCGP


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