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> Protein (NX_P35711)
Protein (NX_P35711)
Protein
Gene SymbolSOX5 to neXtProt (NX_P35711)
DescriptionTranscription factor SOX-5
Chromosome12
Location12p12.1 (23682440 ~ 24103966) to Ensembl
Sequene Features : Isoforms 5, Variants 146, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 146 0
2014-09-19protein level
5 107 0
2014-05-27protein level
5 107 1
2014-02-25protein level
5 106 1
2013-12-09protein level
5 94 1
2013-11-01protein level
5 94 1
2013-09-12protein level
5 94 3
2013-08-17protein level
5 94 3
2013-07-15protein level
5 57 3
2013-06-11protein level
5 57 3
2013-02-12protein level
4 20 6
2012-12-20protein level
4 20 6
2012-10-30protein level
4 22 6
2012-10-07protein level
4 22 2
2012-08-24protein level
4 6 2
2012-07-28protein level
4 6 2
2012-06-08protein level
4 11 2
2012-05-07protein level
4 11 2
2012-04-10protein level
4 11 2
2012-01-13protein level
4 9 2
2011-12-20protein level
4 9 2
2011-11-11protein level
4 9 2
2011-08-23protein level
4 8 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35711-1
1 25 9 83972.9301
NX_P35711-2
0 25 9 82401.2053
NX_P35711-3
1 11 3 41963.7186
NX_P35711-4
0 18 9 70999.28
NX_P35711-5
0 25 9 82718.3454
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3505701,EBI-3505698 SHOX  
  .transcription from RNA polymerase II promoter
.skeletal system development
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleus
2 EBI-3505701,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
3 EBI-3505701,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
4 EBI-3505701,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
5 EBI-3505701,EBI-10172814 PRR20C  
  .N/A .N/A .N/A
6 EBI-3505701,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
7 EBI-3505701,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
8 EBI-3505701,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
9 EBI-3505701,EBI-752030 FAM46B  
  .N/A .N/A .N/A
10 EBI-3505701,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
11 EBI-3505701,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
12 EBI-3505701,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
13 EBI-3505701,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain32
connective tissue33
embryonic tissue9
eye4
kidney4
lung32
lymph node22
mammary gland19
mouth15
skin18
testis52
trachea19
uterus4
Health State
TissuesTPM*
normal13
head and neck tumor7
lung tumor9
non-neoplasia31
skin tumor31
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult10
blastocyst16
fetus50
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.8
adrenal gland1.2
appendix2.9
cerebral cortex8.1
colon1.3
esophagus2.5
gallbladder7.3
heart muscle3
kidney2.1
liver7.6
lung3.4
lymph node4.7
ovary8.2
pancreas1.3
placenta5.5
prostate2
salivary gland3.3
skin4.4
small intestine1
spleen1.6
stomach1.6
testis33.1
thyroid gland5.2
urinary bladder5.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*604975, gene) Sry-box 5; SOX5OMIM


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