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> Protein (NX_P35813)
Protein (NX_P35813)
Protein
Gene SymbolPPM1A to neXtProt (NX_P35813)
DescriptionProtein phosphatase 1A
Chromosome14
Location14q23.1 (60712470 ~ 60765805) to Ensembl
Sequene Features : Isoforms 3, Variants 59, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription, DNA-templated
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 16 more...
.R-SMAD binding
.calmodulin-dependent protein phosphatase activity
.manganese ion binding
  + 3 more...
.neuron projection
.membrane
.voltage-gated calcium channel complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 59 3
2014-09-19protein level
3 45 3
2014-05-27protein level
3 45 3
2014-02-25protein level
3 42 3
2013-12-09protein level
3 31 3
2013-11-01protein level
3 30 3
2013-09-12protein level
3 30 4
2013-08-17protein level
3 30 4
2013-07-15protein level
3 15 3
2013-06-11protein level
3 15 3
2013-02-12protein level
2 4 4
2012-12-20protein level
2 4 4
2012-10-30protein level
2 4 4
2012-10-07protein level
2 4 3
2012-08-24protein level
2 4 3
2012-07-28protein level
2 4 3
2012-06-08protein level
2 5 3
2012-05-07protein level
2 9 3
2012-04-10protein level
2 9 3
2012-01-13protein level
2 4 3
2011-12-20protein level
2 4 3
2011-11-11protein level
2 4 3
2011-08-23protein level
2 4 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35813-1
0 17 4 42420.5635
NX_P35813-2
1 13 4 35934.3706
NX_P35813-3
2 17 3 51333.2189
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-989143,EBI-710484 AXIN1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.Wnt signaling pathway involved in somitogenesis
  + 45 more...
.I-SMAD binding
.armadillo repeat domain binding
.SMAD binding
  + 9 more...
.cell periphery
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 10 more...
2 EBI-989143,EBI-959949 MAPK1  
  .regulation of early endosome to late endosome transport
.regulation of cellular response to heat
.cellular response to granulocyte macrophage colony-stimulating factor stimulus
  + 70 more...
.phosphatase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.protein complex
  + 17 more...
3 EBI-989143,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
4 EBI-989143,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
5 EBI-989143,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
6 EBI-989143,EBI-73946 MAPK14  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of myoblast fusion
.regulation of cytokine production involved in inflammatory response
  + 64 more...
.NFAT protein binding
.ATP binding
.MAP kinase kinase activity
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 4 more...
7 EBI-989143,EBI-992681 RANBP3  
  .intracellular transport
.protein transport
.R-SMAD binding
.Ran GTPase binding
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites50
bladder100
blood32
bone83
bone marrow20
brain53
cervix20
connective tissue20
ear124
embryonic tissue28
eye57
heart22
intestine34
kidney66
larynx42
liver53
lung74
lymph135
lymph node77
mammary gland79
mouth45
muscle84
nerve193
ovary9
pancreas32
parathyroid48
pharynx24
pituitary gland121
placenta35
prostate58
skin52
stomach83
testis87
thymus112
thyroid64
trachea77
uterus68
vascular58
Health State
TissuesTPM*
normal58
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma84
colorectal tumor35
gastrointestinal tumor75
germ cell tumor26
glioma27
head and neck tumor52
kidney tumor43
leukemia21
lung tumor19
lymphoma83
non-neoplasia51
pancreatic tumor19
primitive neuroectodermal tumor of the CNS141
prostate cancer28
skin tumor39
soft tissue/muscle tissue tumor15
uterine tumor110
Developmental Stage
TissuesTPM*
adult50
embryoid body14
blastocyst16
fetus57
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.4
adrenal gland25.1
appendix28.6
bone marrow89.4
cerebral cortex30.1
colon45.5
duodenum43.1
esophagus32
gallbladder27
heart muscle35.6
kidney46.1
liver40.6
lung22.5
lymph node30.2
ovary15.9
pancreas14.6
placenta26.8
prostate35.3
salivary gland30.7
skin18
small intestine44.2
spleen21.2
stomach26
testis73
thyroid gland28.1
urinary bladder34.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Low
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverMedium
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineHigh
spleenMedium
stomach 1Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606108, gene) Protein phosphatase, magnesium-dependent, 1a; PPM1AOMIM


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