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> Protein (NX_P35908)
Protein (NX_P35908)
Protein
Gene SymbolKRT2 to neXtProt (NX_P35908)
DescriptionKeratin, type II cytoskeletal 2 epidermal
Chromosome12
Location12q13.13 (53038342 ~ 53045948) to Ensembl
Sequene Features : Isoforms 1, Variants 135, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.keratinocyte migration
.keratinocyte proliferation
.keratinocyte activation
  + 2 more...
.structural constituent of cytoskeleton .extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 135 1
2014-09-19protein level
1 103 1
2014-05-27protein level
1 103 7
2014-02-25protein level
1 102 7
2013-12-09protein level
1 86 7
2013-11-01protein level
1 78 5
2013-09-12protein level
1 78 6
2013-08-17protein level
1 78 6
2013-07-15protein level
1 62 6
2013-06-11protein level
1 62 6
2013-02-12protein level
1 37 7
2012-12-20protein level
1 37 7
2012-10-30protein level
1 39 7
2012-10-07protein level
1 39 7
2012-08-24protein level
1 34 7
2012-07-28protein level
1 34 7
2012-06-08protein level
1 35 7
2012-05-07protein level
1 35 7
2012-04-10protein level
1 35 7
2012-01-13protein level
1 26 7
2011-12-20protein level
1 26 7
2011-11-11protein level
1 26 6
2011-08-23protein level
1 29 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35908-1
30 0 8 65393.0301
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1247312,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
2 EBI-1247312,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
3 EBI-1247312,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-1247312,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
skin327
Health State
TissuesTPM*
normal21
leukemia10
Developmental Stage
TissuesTPM*
adult1
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
duodenum1.1
skin1117.4
Tissues
TissuesExpression level
cervix, uterineMedium
esophagusHigh
skin 1High
skin 2High
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#146800, phenotype) Ichthyosis, bullous typeOMIM
2(*600194, gene) Keratin 2; KRT2OMIM


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