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> Protein (NX_P35968)
Protein (NX_P35968)
Protein
Gene SymbolKDR to neXtProt (NX_P35968)
DescriptionVascular endothelial growth factor receptor 2
Chromosome4
Location4q12 (55944644 ~ 55991756) to Ensembl
Sequene Features : Isoforms 3, Variants 324, PTMs 37 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of vasculogenesis
.negative regulation of endothelial cell apoptotic process
.positive regulation of ERK1 and ERK2 cascade
  + 39 more...
.Hsp90 protein binding
.vascular endothelial growth factor binding
.growth factor binding
  + 6 more...
.sorting endosome
.membrane raft
.cell junction
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 324 37
2014-09-19protein level
3 248 37
2014-05-27protein level
3 248 37
2014-02-25protein level
3 244 37
2013-12-09protein level
3 207 37
2013-11-01protein level
3 195 37
2013-09-12protein level
3 195 37
2013-08-17protein level
3 195 36
2013-07-15protein level
3 128 36
2013-06-11protein level
3 128 36
2013-02-12protein level
3 59 78
2012-12-20protein level
3 57 78
2012-10-30protein level
3 65 78
2012-10-07protein level
3 65 36
2012-08-24protein level
3 39 36
2012-07-28protein level
3 39 36
2012-06-08protein level
3 31 36
2012-05-07protein level
3 31 36
2012-04-10protein level
3 31 36
2012-01-13protein level
3 31 36
2011-12-20protein level
3 59 36
2011-11-11protein level
3 59 35
2011-08-23protein level
1 38 26
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P35968-1
23 34 2 151430.2024
NX_P35968-2
1 33 0 75847.2866
NX_P35968-3
1 34 0 79583.0404
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1005487,EBI-1187100 NRP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.facioacoustic ganglion development
.protein localization to early endosome
  + 63 more...
.metal ion binding
.vascular endothelial growth factor binding
.cytokine binding
  + 5 more...
.sorting endosome
.receptor complex
.neuronal cell body
  + 12 more...
2 EBI-1005487,EBI-944395 GREM1  
  .positive regulation of cardiac muscle cell differentiation
.positive regulation of receptor activity
.negative regulation of bone mineralization involved in bone maturation
  + 39 more...
.receptor agonist activity
.vascular endothelial growth factor receptor 2 binding
.BMP binding
  + 2 more...
.cell surface
.extracellular space
3 EBI-1005487,EBI-352915 PDCD6  
  .apoptotic signaling pathway
.negative regulation of protein kinase B signaling
.response to calcium ion
  + 12 more...
.binding, bridging
.calcium-dependent protein binding
.protein dimerization activity
  + 4 more...
.endoplasmic reticulum exit site
.extracellular exosome
.nuclear membrane
  + 6 more...
4 EBI-1005487,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
5 EBI-1005487,EBI-1048875 LGALS1  
  .cellular response to organic cyclic compound
.cellular response to glucose stimulus
.response to axon injury
  + 12 more...
.poly(A) RNA binding
.lactose binding
.galactoside binding
.signal transducer activity
.extracellular exosome
.cell surface
.cytoplasm
  + 4 more...
6 EBI-1005487,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
7 EBI-1005487,EBI-1026643 VEGFA  
  .positive regulation of protein kinase D signaling
.positive regulation of protein localization to early endosome
.positive regulation of retinal ganglion cell axon guidance
  + 95 more...
.extracellular matrix binding
.receptor agonist activity
.protein heterodimerization activity
  + 12 more...
.platelet alpha granule lumen
.secretory granule
.membrane
  + 5 more...
8 EBI-1005487,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
9 EBI-1005487,EBI-702960 ITGA2  
  .hepatocyte differentiation
.positive regulation of phagocytosis, engulfment
.positive regulation of transmission of nerve impulse
  + 39 more...
.collagen binding involved in cell-matrix adhesion
.metal ion binding
.collagen receptor activity
  + 2 more...
.perinuclear region of cytoplasm
.basal part of cell
.axon terminus
  + 8 more...
10 EBI-1005487,EBI-1005467 FLT4  
  .positive regulation of protein kinase C signaling
.positive regulation of ERK1 and ERK2 cascade
.regulation of blood vessel remodeling
  + 19 more...
.protein phosphatase binding
.growth factor binding
.ATP binding
  + 2 more...
.receptor complex
.integral component of plasma membrane
.plasma membrane
  + 3 more...
11 EBI-1005487,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
12 EBI-1005487,EBI-947664 HSPG2  
  .cartilage development involved in endochondral bone morphogenesis
.cardiac muscle tissue development
.embryonic skeletal system morphogenesis
  + 16 more...
.metal ion binding
.protein C-terminus binding
.extracellular exosome
.lysosomal lumen
.extracellular matrix
  + 6 more...
13 EBI-1005487,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bone13
brain15
connective tissue20
ear124
embryonic tissue56
eye76
heart55
intestine4
kidney14
liver9
lung29
mammary gland26
mouth15
muscle9
nerve64
pancreas37
parathyroid145
pituitary gland181
placenta60
prostate10
stomach20
testis9
thyroid64
trachea38
uterus38
vascular58
Health State
TissuesTPM*
normal42
breast (mammary gland) tumor10
chondrosarcoma36
colorectal tumor8
gastrointestinal tumor16
germ cell tumor3
glioma27
head and neck tumor29
kidney tumor14
liver tumor10
lung tumor9
non-neoplasia10
uterine tumor22
Developmental Stage
TissuesTPM*
adult34
embryoid body42
blastocyst65
fetus71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.6
adrenal gland9.8
appendix8.8
cerebral cortex3.5
colon4.9
duodenum4.2
esophagus4.5
gallbladder16
heart muscle11.5
kidney18.1
liver14.6
lung28.8
lymph node6.7
ovary4
pancreas2.9
placenta61.1
prostate11.6
salivary gland4.8
skin3.6
small intestine4.2
spleen7.1
stomach5.7
testis2.6
thyroid gland36.4
urinary bladder11.8
Tissues
TissuesExpression level
adrenal glandLow
cervix, uterineMedium
colonLow
esophagusHigh
fallopian tubeLow
kidneyHigh
lungMedium
skin 2Medium
soft tissue 1Medium
soft tissue 2Medium
testisLow
urinary bladderLow
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*191306, gene) Kinase insert domain receptor; KDROMIM
2(#602089, phenotype) Hemangioma, capillary infantileOMIM
3non small cell lung cancer;angiosarcomaCGP


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