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> Protein (NX_P36873)
Protein (NX_P36873)
Protein
Gene SymbolPPP1CC to neXtProt (NX_P36873)
DescriptionSerine/threonine-protein phosphatase PP1-gamma catalytic subunit
Chromosome12
Location12q24.11 (111157485 ~ 111180744) to Ensembl
Sequene Features : Isoforms 2, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 10 more...
.protein N-terminus binding
.metal ion binding
.poly(A) RNA binding
  + 4 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.protein complex
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 27 5
2014-09-19protein level
2 20 5
2014-05-27protein level
2 20 14
2014-02-25protein level
2 20 14
2013-12-09protein level
2 16 15
2013-11-01protein level
2 13 12
2013-09-12protein level
2 13 12
2013-08-17protein level
2 13 12
2013-07-15protein level
2 8 3
2013-06-11protein level
2 8 3
2013-02-12protein level
2 5 6
2012-12-20protein level
2 6 6
2012-10-30protein level
2 7 6
2012-10-07protein level
2 7 3
2012-08-24protein level
2 4 3
2012-07-28protein level
2 4 3
2012-06-08protein level
2 6 3
2012-05-07protein level
2 6 3
2012-04-10protein level
2 6 3
2012-01-13protein level
2 7 3
2011-12-20protein level
2 7 3
2011-11-11protein level
2 7 3
2011-08-23protein level
2 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P36873-1
0 5 13 36959.6198
NX_P36873-2
1 5 13 38493.3182
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356283,EBI-357067 URI1  
  .negative regulation of intrinsic apoptotic signaling pathway
.cellular response to steroid hormone stimulus
.cellular response to growth factor stimulus
  + 5 more...
.phosphatase inhibitor activity
.protein phosphatase inhibitor activity
.chromatin binding
.RNA polymerase II transcription corepressor activity
.dendrite
.mitochondrion
.cytoplasm
  + 2 more...
2 EBI-356283,EBI-768015 CD2BP2  
  .negative regulation of phosphatase activity
.gene expression
.RNA splicing
  + 2 more...
.ribonucleoprotein complex binding .cytoplasm
.U5 snRNP
.nucleoplasm
.nucleus
3 EBI-356283,EBI-296817 ZFYVE9  
  .negative regulation of transforming growth factor beta receptor signaling pathway
.SMAD protein import into nucleus
.SMAD protein complex assembly
  + 3 more...
.metal ion binding
.serine-type peptidase activity
.1-phosphatidylinositol binding
.early endosome membrane
.early endosome
4 EBI-356289,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
5 EBI-356283,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
6 EBI-356283,EBI-1056517 PPP1R2  
  .regulation of phosphoprotein phosphatase activity
.negative regulation of catalytic activity
.regulation of signal transduction
  + 2 more...
.protein serine/threonine phosphatase inhibitor activity .N/A
7 EBI-356283,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
8 EBI-3964623,EBI-4311709 TCTEX1D4  
  .N/A .protein phosphatase 1 binding .sperm flagellum
.axoneme
.microtubule organizing center
  + 2 more...
9 EBI-3964623,EBI-4311771 PPP1R32  
  .N/A .phosphatase binding .N/A
10 EBI-3964623,EBI-636085 RANBP9  
  .negative regulation of ERK1 and ERK2 cascade
.axon guidance
.microtubule nucleation
.protein complex assembly
.enzyme binding
.Ran GTPase binding
.microtubule associated complex
.cytosol
.nucleus
11 EBI-356283,EBI-4311573 CSRNP1  
  .face morphogenesis
.palate development
.skeletal system morphogenesis
  + 4 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
12 EBI-356283,EBI-5235958 CSRNP2  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of phosphatase activity
.apoptotic process
.sequence-specific DNA binding
.phosphatase binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland273
ascites125
bladder368
blood155
bone125
bone marrow205
brain161
cervix226
connective tissue114
ear62
embryonic tissue328
esophagus148
eye153
heart44
intestine155
kidney175
larynx85
liver107
lung116
lymph609
lymph node200
mammary gland105
mouth136
muscle84
nerve321
ovary118
pancreas28
parathyroid339
pharynx24
pituitary gland302
placenta95
prostate158
salivary gland197
skin194
spleen243
stomach73
testis248
thymus112
thyroid85
trachea154
umbilical cord72
uterus228
vascular212
Health State
TissuesTPM*
normal133
adrenal tumor237
bladder carcinoma454
breast (mammary gland) tumor118
cervical tumor289
chondrosarcoma120
colorectal tumor124
esophageal tumor173
gastrointestinal tumor143
germ cell tumor372
glioma102
head and neck tumor67
kidney tumor203
leukemia179
liver tumor166
lung tumor97
lymphoma470
non-neoplasia155
ovarian tumor118
pancreatic tumor57
primitive neuroectodermal tumor of the CNS283
prostate cancer173
retinoblastoma323
skin tumor215
soft tissue/muscle tissue tumor239
uterine tumor99
Developmental Stage
TissuesTPM*
adult111
embryoid body171
blastocyst358
neonate321
fetus152
infant297
juvenile251
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue57.5
adrenal gland75.2
appendix94
bone marrow81.2
cerebral cortex46.4
colon112.1
duodenum193.4
esophagus102.3
gallbladder72.4
heart muscle70.4
kidney51
liver36.2
lung58.6
lymph node152.1
ovary94.6
pancreas37.3
placenta56.7
prostate63.8
salivary gland59.1
skin64.7
small intestine153.7
spleen75.6
stomach79.2
testis131.6
thyroid gland64.5
urinary bladder95.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176914, gene) Protein phosphatase 1, catalytic subunit, gamma isoform; PPP1CCOMIM


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