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> Protein (NX_P37198)
Protein (NX_P37198)
Protein
Gene SymbolNUP62 to neXtProt (NX_P37198)
DescriptionNuclear pore glycoprotein p62
Chromosome19
Location19q13.33 (50410082 ~ 50433020) to Ensembl
Sequene Features : Isoforms 1, Variants 75, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 75 8
2014-09-19protein level
1 61 8
2014-05-27protein level
1 61 8
2014-02-25protein level
1 61 8
2013-12-09protein level
1 54 8
2013-11-01protein level
1 51 5
2013-09-12protein level
1 51 5
2013-08-17protein level
1 51 5
2013-07-15protein level
1 43 3
2013-06-11protein level
1 43 3
2013-02-12protein level
1 21 4
2012-12-20protein level
1 21 3
2012-10-30protein level
1 23 3
2012-10-07protein level
1 23 3
2012-08-24protein level
1 21 3
2012-07-28protein level
1 21 3
2012-06-08protein level
1 24 3
2012-05-07protein level
1 24 3
2012-04-10protein level
1 24 3
2012-01-13protein level
1 19 3
2011-12-20protein level
1 19 3
2011-11-11protein level
1 19 3
2011-08-23protein level
1 19 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P37198-1
13 0 0 53222.316
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347978,EBI-10172867 SSC5D  
  .negative regulation of interleukin-8 secretion
.defense response to Gram-positive bacterium
.defense response to Gram-negative bacterium
  + 4 more...
.extracellular matrix binding
.laminin binding
.scavenger receptor activity
.fibronectin binding
.extracellular matrix
.membrane
.cytoplasm
  + 2 more...
2 EBI-347978,EBI-708350 ATXN7  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of insulin-like growth factor receptor signaling pathway
.negative regulation of phosphorylation
  + 6 more...
.chromatin binding .nuclear matrix
.microtubule cytoskeleton
.cytoplasm
  + 3 more...
3 EBI-347978,EBI-536879 OIP5  
  .cell division
.CENP-A containing nucleosome assembly
.cell communication
  + 2 more...
.N/A .Cajal body
.chromocenter
.cytoplasm
  + 4 more...
4 EBI-347978,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
5 EBI-347978,EBI-749483 SNAPC5  
  .gene expression
.transcription initiation from RNA polymerase III promoter
.transcription from RNA polymerase III promoter
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity .nucleolus
.nucleoplasm
.nucleus
6 EBI-347978,EBI-704216 FABP3  
  .positive regulation of phospholipid biosynthetic process
.response to fatty acid
.phospholipid homeostasis
  + 9 more...
.oleic acid binding
.icosatetraenoic acid binding
.long-chain fatty acid binding
  + 2 more...
.extracellular exosome
.sarcoplasm
.cytosol
.extracellular space
7 EBI-347978,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
8 EBI-347978,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
9 EBI-347978,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
10 EBI-347978,EBI-591778 NUTF2  
  .protein export from nucleus
.protein import into nucleus, translocation
.Ran GTPase binding
.transporter activity
.extracellular exosome
.cytosol
.nuclear pore
11 EBI-347978,EBI-2556750 HSF2  
  .positive regulation of transcription from RNA polymerase II promoter
.spermatogenesis
.transcription from RNA polymerase II promoter
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.cytoplasm
.nucleus
12 EBI-347978,EBI-10227494 BFSP1  
  .lens fiber cell development
.cell maturation
.structural constituent of eye lens
.structural constituent of cytoskeleton
.actin cytoskeleton
.plasma membrane
.intermediate filament
  + 2 more...
13 EBI-347978,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
14 EBI-347978,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
15 EBI-347978,EBI-10241443 CCDC153  
  .N/A .N/A .N/A
16 EBI-347978,EBI-2836982 CCDC121  
  .N/A .N/A .N/A
17 EBI-347978,EBI-2557212 IKBIP  
  .response to X-ray .N/A .integral component of membrane
.membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
18 EBI-347978,EBI-2515234 CENPU  
  .chordate embryonic development
.CENP-A containing nucleosome assembly
.viral process
  + 5 more...
.N/A .cytosol
.microtubule organizing center
.nucleoplasm
  + 2 more...
19 EBI-347978,EBI-741048 NUP54  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.cytoplasm
.nucleoplasm
  + 2 more...
20 EBI-347978,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
21 EBI-347978,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
22 EBI-347978,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
23 EBI-347978,EBI-10269342 CCDC150  
  .N/A .N/A .N/A
24 EBI-347978,EBI-747505 C1orf216  
  .N/A .N/A .N/A
25 EBI-347978,EBI-3925742 AGR3  
  .N/A .dystroglycan binding .extracellular region
26 EBI-347978,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
27 EBI-347978,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
28 EBI-347978,EBI-745085 PHF21A  
  .chromatin modification
.blood coagulation
.regulation of transcription, DNA-templated
  + 4 more...
.zinc ion binding
.chromatin binding
.DNA binding
.nucleoplasm
.histone deacetylase complex
29 EBI-347978,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
30 EBI-347978,EBI-10293124 XPO6  
  .protein export from nucleus .protein transporter activity .plasma membrane
.cytoplasm
.nucleolus
  + 2 more...
31 EBI-347978,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
32 EBI-347978,EBI-2811583 NUPL1  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.nuclear pore
.nuclear envelope
33 EBI-347978,EBI-1047335 ISCU  
  .protein maturation by iron-sulfur cluster transfer
.[2Fe-2S] cluster assembly
.small molecule metabolic process
  + 3 more...
.4 iron, 4 sulfur cluster binding
.2 iron, 2 sulfur cluster binding
.iron-sulfur transferase activity
  + 3 more...
.cytosol
.mitochondrial matrix
.mitochondrion
  + 2 more...
34 EBI-347978,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
35 EBI-347978,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
36 EBI-347978,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
37 EBI-347978,EBI-713677 CRCT1  
  .N/A .N/A .N/A
38 EBI-347978,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
39 EBI-347978,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites150
bladder100
blood163
bone41
bone marrow82
brain160
cervix82
connective tissue114
ear124
embryonic tissue103
eye153
heart89
intestine155
kidney128
larynx42
liver73
lung134
lymph474
lymph node77
mammary gland119
mouth332
muscle122
ovary88
pancreas70
pharynx24
placenta116
prostate89
salivary gland246
skin180
spleen318
stomach41
testis392
thymus150
thyroid21
tonsil235
trachea19
umbilical cord72
uterus112
vascular116
Health State
TissuesTPM*
normal122
adrenal tumor79
breast (mammary gland) tumor171
cervical tumor86
chondrosarcoma72
colorectal tumor248
gastrointestinal tumor101
germ cell tumor269
glioma130
head and neck tumor179
kidney tumor174
leukemia52
liver tumor114
lung tumor253
lymphoma332
non-neoplasia93
ovarian tumor39
pancreatic tumor142
primitive neuroectodermal tumor of the CNS133
prostate cancer77
retinoblastoma301
skin tumor159
soft tissue/muscle tissue tumor151
uterine tumor44
Developmental Stage
TissuesTPM*
adult108
embryoid body71
blastocyst146
neonate321
fetus184
infant85
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.6
adrenal gland16.8
appendix33.3
bone marrow16.1
cerebral cortex13.8
colon19.5
duodenum19.9
esophagus17.4
gallbladder18.2
heart muscle15.3
kidney14.1
liver10.2
lung19.7
lymph node35.2
ovary26.6
pancreas8.3
placenta22.1
prostate20.3
salivary gland15.3
skin19.7
small intestine18.6
spleen31.1
stomach20.8
testis48.2
thyroid gland12.6
urinary bladder23.8
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaHigh
prostateLow
rectumHigh
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#271930, phenotype) Striatonigral degeneration, infantile; SNDIOMIM
2(*605815, gene) Nucleoporin, 62-kd; NUP62OMIM


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