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> Protein (NX_P37231)
Protein (NX_P37231)
Protein
Gene SymbolPPARG to neXtProt (NX_P37231)
DescriptionPeroxisome proliferator-activated receptor gamma
Chromosome3
Location3p25.2 (12328867 ~ 12475855) to Ensembl
Sequene Features : Isoforms 3, Variants 65, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of pancreatic stellate cell proliferation
.response to metformin
.cellular response to hyperoxia
  + 64 more...
.alpha-actinin binding
.arachidonic acid binding
.retinoid X receptor binding
  + 15 more...
.RNA polymerase II transcription factor complex
.perinuclear region of cytoplasm
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 65 2
2014-09-19protein level
3 53 2
2014-05-27protein level
3 53 2
2014-02-25protein level
3 53 2
2013-12-09protein level
3 45 2
2013-11-01protein level
3 39 2
2013-09-12protein level
3 39 2
2013-08-17protein level
3 39 2
2013-07-15protein level
3 23 2
2013-06-11protein level
3 23 2
2013-02-12protein level
3 15 6
2012-12-20protein level
3 15 6
2012-10-30protein level
3 19 6
2012-10-07protein level
3 19 1
2012-08-24protein level
3 19 1
2012-07-28protein level
3 19 1
2012-06-08protein level
3 22 1
2012-05-07protein level
2 18 1
2012-04-10protein level
2 18 1
2012-01-13protein level
2 17 1
2011-12-20protein level
2 17 1
2011-11-11protein level
2 17 1
2011-08-23protein level
2 17 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P37231-1
1 19 1 57582.9146
NX_P37231-2
0 20 1 54645.6513
NX_P37231-3
1 5 1 21566.2114
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-781384,EBI-781301 EDF1  
  .positive regulation of transcription, DNA-templated
.endothelial cell differentiation
.positive regulation of DNA binding
  + 4 more...
.poly(A) RNA binding
.sequence-specific DNA binding
.transcription coactivator activity
.extracellular exosome
.cytoplasm
.nucleolus
  + 2 more...
2 EBI-781384,EBI-1104674 CLU  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of neurofibrillary tangle assembly
  + 34 more...
.misfolded protein binding
.chaperone binding
.ubiquitin protein ligase binding
.apical dendrite
.neurofibrillary tangle
.blood microparticle
  + 15 more...
3 EBI-781384,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-781416,EBI-1041567 CDK5  
  .positive regulation of actin cytoskeleton reorganization
.regulation of synaptic vesicle recycling
.negative regulation of neuron death
  + 63 more...
.tau-protein kinase activity
.ErbB-3 class receptor binding
.acetylcholine receptor activator activity
  + 6 more...
.postsynaptic membrane
.perikaryon
.neuronal cell body
  + 14 more...
5 EBI-781384,EBI-488506 SMARCD3  
  .positive regulation of transcription, DNA-templated
.small molecule metabolic process
.cellular lipid metabolic process
  + 10 more...
.nuclear hormone receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
.ligand-dependent nuclear receptor binding
  + 3 more...
.nBAF complex
.npBAF complex
.SWI/SNF complex
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bladder33
bone69
brain2
cervix61
connective tissue26
embryonic tissue4
heart11
intestine86
kidney28
liver14
lung32
mammary gland6
nerve64
ovary19
pancreas9
pharynx24
placenta91
prostate10
skin4
spleen18
stomach20
testis4
vascular19
Health State
TissuesTPM*
normal17
bladder carcinoma113
chondrosarcoma72
colorectal tumor115
gastrointestinal tumor25
germ cell tumor11
head and neck tumor7
kidney tumor29
liver tumor31
lung tumor19
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
prostate cancer9
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult36
embryoid body14
fetus5
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue137.4
adrenal gland4.3
appendix9.2
bone marrow1.3
cerebral cortex2
colon47.8
duodenum20.9
esophagus6.7
gallbladder13.7
heart muscle7.8
kidney13.3
liver11.8
lung20.7
lymph node5.4
ovary12.8
pancreas1.3
placenta38.3
prostate4.5
salivary gland4.4
skin1.1
small intestine15
spleen11.6
stomach36.6
testis7.7
thyroid gland13.3
urinary bladder60.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#137800, phenotype) Glioma susceptibility 1; GLM1OMIM
2(*601487, gene) Peroxisome proliferator-activated receptor-gamma; PPARGOMIM
3(#601665, phenotype) ObesityOMIM
4(#604367, phenotype) Lipodystrophy, familial partial, type 3; FPLD3OMIM
5(%606641, phenotype) Body mass index; BMIOMIM
6(#609338, phenotype) Carotid intimal medial thickness 1OMIM
7follicular thyroid;Insulin resistance ; lipodystrophy;familial partial L;diabetes mellitus;insulin-resistantI;with acanthosis nigricans and hypertensionCGP


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