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> Protein (NX_P37840)
Protein (NX_P37840)
Protein
Gene SymbolSNCA to neXtProt (NX_P37840)
DescriptionAlpha-synuclein
Chromosome4
Location4q22.1 (90645250 ~ 90759466) to Ensembl
Sequene Features : Isoforms 3, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of reactive oxygen species biosynthetic process
.regulation of synaptic vesicle recycling
.positive regulation of hydrogen peroxide catabolic process
  + 63 more...
.phosphoprotein binding
.tau protein binding
.dynein binding
  + 14 more...
.perinuclear region of cytoplasm
.fibril
.terminal bouton
  + 21 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 22 5
2014-09-19protein level
3 17 5
2014-05-27protein level
3 17 6
2014-02-25protein level
3 17 6
2013-12-09protein level
3 15 6
2013-11-01protein level
3 14 5
2013-09-12protein level
3 14 5
2013-08-17protein level
3 14 5
2013-07-15protein level
3 8 4
2013-06-11protein level
3 8 4
2013-02-12protein level
3 5 10
2012-12-20protein level
3 5 7
2012-10-30protein level
3 6 7
2012-10-07protein level
3 6 3
2012-08-24protein level
3 5 3
2012-07-28protein level
3 5 3
2012-06-08protein level
3 16 3
2012-05-07protein level
3 16 3
2012-04-10protein level
3 16 3
2012-01-13protein level
3 15 3
2011-12-20protein level
3 15 3
2011-11-11protein level
3 15 3
2011-08-23protein level
3 15 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P37840-1
0 5 2 14451.1784
NX_P37840-2
1 4 2 11364.9217
NX_P37840-3
1 4 1 13100.4569
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-985879,EBI-3932264 MT-CO3  
  .small molecule metabolic process
.cellular metabolic process
.respiratory electron transport chain
  + 4 more...
.cytochrome-c oxidase activity .respiratory chain complex IV
.integral component of membrane
.mitochondrial inner membrane
2 EBI-985879,EBI-629985 HSPA1A  
  .N/A .N/A .N/A
3 EBI-985879,EBI-366233 MAPT  
  .regulation of microtubule-based movement
.generation of neurons
.axon extension
  + 13 more...
.lipoprotein particle binding
.apolipoprotein binding
.enzyme binding
  + 3 more...
.tubulin complex
.cytoplasmic ribonucleoprotein granule
.nuclear periphery
  + 7 more...
4 EBI-985879,EBI-717274 SYN1  
  .regulation of synaptic vesicle exocytosis
.regulation of neurotransmitter secretion
.neurotransmitter secretion
.synaptic transmission
.protein kinase binding
.ATP binding
.transporter activity
.catalytic activity
.dendrite
.cell junction
.synaptic vesicle
  + 2 more...
5 EBI-985879,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
6 EBI-985879,EBI-373586 GSK3B  
  .positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
7 EBI-985879,EBI-6661445 SLC6A3  
  .cation transmembrane transport
.ammonium transmembrane transport
.prepulse inhibition
  + 20 more...
.dopamine binding
.monoamine transmembrane transporter activity
.drug binding
  + 2 more...
.neuronal cell body
.axon
.integral component of membrane
  + 3 more...
8 EBI-9684465,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
9 EBI-985879,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
10 EBI-985879,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
11 EBI-985879,EBI-717182 SNCAIP  
  .regulation of inclusion body assembly
.regulation of neurotransmitter secretion
.dopamine metabolic process
.cell death
.identical protein binding
.ubiquitin protein ligase binding
.neuronal cell body
.presynaptic membrane
.synaptic vesicle
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder66
blood57
bone41
brain68
connective tissue268
ear124
embryonic tissue14
eye14
heart212
intestine43
kidney9
liver19
lung26
mammary gland13
nerve128
ovary9
pancreas74
placenta31
prostate5
skin75
testis9
uterus12
vascular19
Health State
TissuesTPM*
normal53
adrenal tumor158
breast (mammary gland) tumor21
gastrointestinal tumor75
germ cell tumor18
glioma55
leukemia10
lung tumor19
non-neoplasia20
ovarian tumor13
skin tumor95
soft tissue/muscle tissue tumor319
uterine tumor22
Developmental Stage
TissuesTPM*
adult42
embryoid body14
fetus118
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.5
adrenal gland12.6
appendix11.5
bone marrow180.2
cerebral cortex273.7
colon9.7
duodenum4.1
esophagus17.3
gallbladder9.2
heart muscle25.2
kidney10.1
liver2.1
lung9.3
lymph node3.2
ovary35.8
pancreas1
placenta21.6
prostate12.6
salivary gland8.4
skin23.6
small intestine5.3
spleen9
stomach2.1
testis4.4
thyroid gland24.9
urinary bladder15
Tissues
TissuesExpression level
bone marrowMedium
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexHigh
colonLow
esophagusLow
heart muscleLow
kidneyHigh
oral mucosaMedium
ovaryMedium
skin 1High
skin 2Medium
soft tissue 1High
spleenMedium
testisMedium
thyroid glandLow
tonsilLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#127750, phenotype) Dementia, lewy body; DLBOMIM
2(*163890, gene) Synuclein, alpha; SNCAOMIM
3(#168600, phenotype) Parkinson disease, late-onset; PDOMIM
4(#168601, phenotype) Parkinson disease 1, autosomal dominant; PARK1OMIM
5(#605543, phenotype) Parkinson disease 4, autosomal dominant; PARK4OMIM


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