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> Protein (NX_P38398)
Protein (NX_P38398)
Protein
Gene SymbolBRCA1 to neXtProt (NX_P38398)
DescriptionBreast cancer type 1 susceptibility protein
Chromosome17
Location17q21.31 (41196312 ~ 41277500) to Ensembl
Sequene Features : Isoforms 7, Variants 517, PTMs 34 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 517 34
2014-09-19protein level
7 474 34
2014-05-27protein level
6 471 34
2014-02-25protein level
6 471 34
2013-12-09protein level
6 348 34
2013-11-01protein level
6 337 33
2013-09-12protein level
6 337 31
2013-08-17protein level
6 343 31
2013-07-15protein level
6 292 31
2013-06-11protein level
6 292 31
2013-02-12protein level
6 257 147
2012-12-20protein level
6 256 147
2012-10-30protein level
6 298 147
2012-10-07protein level
6 298 36
2012-08-24protein level
6 280 36
2012-07-28protein level
6 294 36
2012-06-08protein level
6 320 36
2012-05-07protein level
5 320 36
2012-04-10protein level
5 319 36
2012-01-13protein level
5 672 36
2011-12-20protein level
5 672 36
2011-11-11protein level
5 672 30
2011-08-23protein level
5 672 29
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P38398-1
0 89 0 207591.3448
NX_P38398-2
0 2 0 7171.6594
NX_P38398-3
0 34 0 84947.3145
NX_P38398-4
0 88 0 205709.3884
NX_P38398-5
1 32 0 80539.3468
NX_P38398-6
2 31 0 78115.8441
NX_P38398-7
2 89 0 210134.5685
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-349905,EBI-974488 CHEK1  
  .regulation of histone H3-K9 acetylation
.negative regulation of DNA biosynthetic process
.replicative senescence
  + 17 more...
.histone kinase activity (H3-T11 specific)
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.intracellular membrane-bounded organelle
.cytosol
.centrosome
  + 6 more...
2 EBI-349905,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
3 EBI-349905,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
4 EBI-349905,EBI-352528 HSPD1  
  .protein maturation
.chaperone-mediated protein complex assembly
.positive regulation of T cell activation
  + 21 more...
.chaperone binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.lipopolysaccharide receptor complex
.protein complex
  + 13 more...
5 EBI-349905,EBI-494830 H2AFX  
  .meiotic cell cycle
.positive regulation of DNA repair
.response to ionizing radiation
  + 7 more...
.histone binding
.enzyme binding
.damaged DNA binding
.DNA binding
.extracellular exosome
.site of double-strand break
.replication fork
  + 7 more...
6 EBI-349905,EBI-375001 CCND1  
  .negative regulation of cell cycle arrest
.response to UV-A
.mammary gland alveolus development
  + 34 more...
.proline-rich region binding
.histone deacetylase binding
.protein kinase binding
  + 5 more...
.transcriptional repressor complex
.membrane
.tight junction
  + 5 more...
7 EBI-349905,EBI-519526 CCNE1  
  .regulation of cell cycle
.cell division
.positive regulation of transcription, DNA-templated
  + 7 more...
.androgen receptor binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.transcription coactivator activity
.cytosol
.nucleoplasm
.nucleus
.cyclin-dependent protein kinase holoenzyme complex
8 EBI-349905,EBI-356283 PPP1CC  
  .cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 10 more...
.protein N-terminus binding
.metal ion binding
.poly(A) RNA binding
  + 4 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.protein complex
  + 11 more...
9 EBI-349905,EBI-349938 KPNA2  
  .cytokine-mediated signaling pathway
.viral process
.NLS-bearing protein import into nucleus
  + 2 more...
.poly(A) RNA binding
.histone deacetylase binding
.protein transporter activity
.nuclear localization sequence binding
.membrane
.cytosol
.cytoplasm
.nucleoplasm
10 EBI-349905,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
11 EBI-349905,EBI-352350 PPP1CB  
  .cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 13 more...
.myosin-light-chain-phosphatase activity
.metal ion binding
.protein kinase binding
  + 2 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 7 more...
12 EBI-349905,EBI-359622 GTF2I  
  .negative regulation of cytosolic calcium ion concentration
.negative regulation of angiogenesis
.transition between slow and fast fiber
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.neuronal cell body
.cell projection
.membrane
  + 3 more...
13 EBI-349905,EBI-717681 ACACA  
  .malonyl-CoA biosynthetic process
.lipid homeostasis
.protein homotetramerization
  + 14 more...
.metal ion binding
.ATP binding
.biotin carboxylase activity
.acetyl-CoA carboxylase activity
.extracellular exosome
.actin cytoskeleton
.cytosol
  + 3 more...
14 EBI-349905,EBI-701903 FHL2  
  .heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
15 EBI-349905,EBI-2867186 IFI16  
  .negative regulation of cysteine-type endopeptidase activity
.activation of cysteine-type endopeptidase activity
.intrinsic apoptotic signaling pathway by p53 class mediator
  + 23 more...
.poly(A) RNA binding
.identical protein binding
.transcription factor binding
  + 4 more...
.nuclear speck
.membrane
.cytosol
  + 4 more...
16 EBI-349905,EBI-1263058 ZCCHC8  
  .mRNA splicing, via spliceosome .poly(A) RNA binding
.zinc ion binding
.catalytic step 2 spliceosome
.nucleoplasm
.nucleus
17 EBI-349905,EBI-1263451 FAM175A  
  .positive regulation of DNA repair
.G2 DNA damage checkpoint
.chromatin modification
  + 2 more...
.polyubiquitin binding .BRCA1-A complex
.nucleus
18 EBI-349905,EBI-349900 BRAP  
  .protein ubiquitination
.negative regulation of signal transduction
.Ras protein signal transduction
.MAPK cascade
.ubiquitin protein ligase activity
.ubiquitin binding
.ligase activity
  + 4 more...
.nuclear membrane
.cytoplasm
.ubiquitin ligase complex
19 EBI-349905,EBI-347721 NELFB  
  .positive regulation of viral transcription
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.N/A .NELF complex
.cytoplasm
.nucleoplasm
20 EBI-349905,EBI-1791447 BAP1  
  .positive regulation of protein targeting to mitochondrion
.protein K48-linked deubiquitination
.regulation of cell cycle
  + 7 more...
.peptidase activity
.ubiquitin-specific protease activity
.chromatin binding
.PR-DUB complex
.cytoplasm
.nucleoplasm
.nucleus
21 EBI-349905,EBI-725300 UIMC1  
  .histone H2A K63-linked deubiquitination
.negative regulation of transcription, DNA-templated
.positive regulation of DNA repair
  + 4 more...
.K63-linked polyubiquitin binding
.histone binding
.BRCA1-A complex
.nucleus
22 EBI-349905,EBI-745715 RBBP8  
  .meiotic cell cycle
.cell division
.G2 DNA damage checkpoint
  + 10 more...
.damaged DNA binding
.RNA polymerase II transcription corepressor activity
.RNA polymerase II repressing transcription factor binding
.single-stranded DNA endodeoxyribonuclease activity
.transcriptional repressor complex
.nucleolus
.nucleoplasm
.nucleus
23 EBI-349905,EBI-473181 BARD1  
  .protein K6-linked ubiquitination
.negative regulation of protein export from nucleus
.positive regulation of protein catabolic process
  + 9 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase binding
  + 4 more...
.BRCA1-A complex
.intracellular membrane-bounded organelle
.BRCA1-BARD1 complex
  + 5 more...
24 EBI-349905,EBI-3509650 BRIP1  
  .small molecule metabolic process
.DNA duplex unwinding
.regulation of transcription from RNA polymerase II promoter
  + 2 more...
.4 iron, 4 sulfur cluster binding
.metal ion binding
.ATP binding
  + 2 more...
.nuclear membrane
.cytoplasm
.nucleus
25 EBI-349905,EBI-396421 ZNF350  
  .negative regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
.transcriptional repressor complex
.nuclear matrix
.nucleoplasm
.nucleus
26 EBI-349905,EBI-399128 TRRAP  
  .histone H2A acetylation
.histone H4 acetylation
.histone deubiquitination
  + 7 more...
.phosphotransferase activity, alcohol group as acceptor
.kinase activity
.transcription coactivator activity
.transcription cofactor activity
.NuA4 histone acetyltransferase complex
.transcription factor TFTC complex
.STAGA complex
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
bladder66
blood8
bone13
bone marrow20
brain10
cervix41
embryonic tissue23
eye14
intestine17
kidney14
liver38
lung17
lymph45
lymph node122
mammary gland39
muscle28
ovary39
pancreas18
placenta3
prostate21
skin80
testis20
thymus12
uterus30
Health State
TissuesTPM*
normal15
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor33
germ cell tumor41
glioma9
kidney tumor29
leukemia10
liver tumor41
lung tumor29
lymphoma41
ovarian tumor13
primitive neuroectodermal tumor of the CNS47
prostate cancer19
retinoblastoma43
skin tumor135
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult16
embryoid body14
blastocyst32
fetus19
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.1
adrenal gland1.8
appendix5.9
bone marrow6.6
cerebral cortex2.4
colon5.6
duodenum2.7
esophagus3.2
gallbladder1.7
heart muscle2.3
kidney1.7
liver3.1
lung2.6
lymph node9.4
ovary1.7
pancreas1.2
placenta3.2
prostate1.7
salivary gland1.3
skin3.6
small intestine3.6
spleen3
stomach3.2
testis12
thyroid gland7.9
urinary bladder3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*113705, gene) Breast cancer 1 gene; BRCA1OMIM
2(#114480, phenotype) Breast cancerOMIM
3(#167000, phenotype) Ovarian cancerOMIM
4(#604370, phenotype) Breast-ovarian cancer, familial, susceptibility to, 1; BROVCA1OMIM
5(#614320, phenotype) Pancreatic cancer, susceptibility to, 4; PNCA4OMIM
6ovarian;breast;Hereditary breast/ovarian cancerCGP


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