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> Protein (NX_P38432)
Protein (NX_P38432)
Protein
Gene SymbolCOIL to neXtProt (NX_P38432)
DescriptionCoilin
Chromosome17
Location17q22 (55015548 ~ 55038415) to Ensembl
Sequene Features : Isoforms 1, Variants 65, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 65 15
2014-09-19protein level
1 48 15
2014-05-27protein level
1 48 15
2014-02-25protein level
1 48 15
2013-12-09protein level
1 38 15
2013-11-01protein level
1 36 14
2013-09-12protein level
1 36 14
2013-08-17protein level
1 36 14
2013-07-15protein level
1 26 14
2013-06-11protein level
1 26 14
2013-02-12protein level
1 14 13
2012-12-20protein level
1 12 13
2012-10-30protein level
1 18 13
2012-10-07protein level
1 18 13
2012-08-24protein level
1 17 13
2012-07-28protein level
1 17 13
2012-06-08protein level
1 17 13
2012-05-07protein level
1 17 13
2012-04-10protein level
1 17 13
2012-01-13protein level
1 8 12
2011-12-20protein level
1 8 12
2011-11-11protein level
1 8 10
2011-08-23protein level
1 8 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P38432-1
25 0 0 62569.7397
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-945751,EBI-353208 XRCC6  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
2 EBI-945751,EBI-357997 XRCC5  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 17 more...
.poly(A) RNA binding
.transcription regulatory region DNA binding
.telomeric DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 7 more...
3 EBI-945751,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
4 EBI-945751,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
5 EBI-945751,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
6 EBI-945751,EBI-6657662 FGF12  
  .negative regulation of cation channel activity
.regulation of sodium ion transmembrane transporter activity
.regulation of sodium ion transmembrane transport
  + 12 more...
.ion channel binding
.sodium channel regulator activity
.heparin binding
.growth factor activity
.nucleus
.extracellular space
7 EBI-945751,EBI-356900 SNRPF  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 7 more...
.RNA binding .catalytic step 2 spliceosome
.SMN-Sm protein complex
.pICln-Sm protein complex
  + 10 more...
8 EBI-945751,EBI-359527 POLR2L  
  .positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
9 EBI-945751,EBI-712344 PTS  
  .regulation of nitric-oxide synthase activity
.nitric oxide metabolic process
.small molecule metabolic process
  + 3 more...
.metal ion binding
.identical protein binding
.6-pyruvoyltetrahydropterin synthase activity
.cytosol
.mitochondrion
.cytoplasm
10 EBI-945751,EBI-1642831 PDE4D  
  .negative regulation of relaxation of cardiac muscle
.regulation of cell communication by electrical coupling involved in cardiac conduction
.adrenergic receptor signaling pathway involved in positive regulation of heart rate
  + 29 more...
.scaffold protein binding
.ATPase binding
.metal ion binding
  + 8 more...
.calcium channel complex
.myofibril
.apical plasma membrane
  + 5 more...
11 EBI-945751,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
12 EBI-945751,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
13 EBI-945751,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
14 EBI-945751,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
15 EBI-945751,EBI-2556091 WDR34  
  .organelle organization .N/A .ciliary tip
.primary cilium
.ciliary basal body
  + 3 more...
16 EBI-945751,EBI-751267 PDLIM5  
  .regulation of dendritic spine morphogenesis
.regulation of synapse assembly
.actinin binding
.zinc ion binding
.protein kinase C binding
.actin binding
.postsynaptic membrane
.neuron projection
.cell junction
  + 5 more...
17 EBI-945751,EBI-1769146 VRK1  
  .Golgi disassembly
.histone H3-T3 phosphorylation
.cell division
  + 10 more...
.histone kinase activity (H3-T3 specific)
.histone kinase activity (H3-S10 specific)
.nucleosomal histone binding
  + 4 more...
.cytosol
.spindle
.Golgi stack
  + 4 more...
18 EBI-945751,EBI-79165 PICK1  
  .dendritic spine maintenance
.dendritic spine organization
.long term synaptic depression
  + 17 more...
.Arp2/3 complex binding
.actin filament binding
.metal ion binding
  + 8 more...
.neuronal postsynaptic density
.perinuclear region of cytoplasm
.postsynaptic membrane
  + 10 more...
19 EBI-945751,EBI-2843626 ARMCX1  
  .N/A .N/A .integral component of membrane
20 EBI-945751,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
21 EBI-945751,EBI-719554 DRG1  
  .multicellular organismal development
.transcription, DNA-templated
.identical protein binding
.transcription factor binding
.GTP binding
.membrane
.polysome
.cytoplasm
22 EBI-945751,EBI-2896123 AK6  
  .nucleotide phosphorylation .ATPase activity
.ATP binding
.adenylate kinase activity
.membrane
.Cajal body
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood8
bone27
bone marrow20
brain9
cervix103
connective tissue13
ear124
embryonic tissue51
eye57
heart44
intestine56
kidney14
liver48
lung23
lymph node11
mammary gland13
mouth30
muscle18
pancreas42
placenta84
prostate31
skin4
spleen18
testis98
thymus12
uterus30
Health State
TissuesTPM*
normal37
adrenal tumor79
breast (mammary gland) tumor10
cervical tumor144
chondrosarcoma24
colorectal tumor8
gastrointestinal tumor25
germ cell tumor53
glioma9
head and neck tumor14
kidney tumor29
leukemia10
liver tumor31
lung tumor29
lymphoma83
non-neoplasia10
pancreatic tumor28
primitive neuroectodermal tumor of the CNS94
prostate cancer9
retinoblastoma150
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult28
embryoid body57
blastocyst32
fetus53
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.2
adrenal gland7.6
appendix9.3
bone marrow11.9
cerebral cortex8
colon9.4
duodenum8.2
esophagus9.5
gallbladder7.8
heart muscle6.6
kidney8.1
liver6
lung8.1
lymph node12.3
ovary11.4
pancreas3.8
placenta12
prostate9.7
salivary gland7.1
skin7.9
small intestine9.3
spleen8.9
stomach8.1
testis84.6
thyroid gland12.2
urinary bladder10.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600272, gene) Coilin; COILOMIM


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