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> Protein (NX_P38646)
Protein (NX_P38646)
Protein
Gene SymbolHSPA9 to neXtProt (NX_P38646)
DescriptionStress-70 protein, mitochondrial
Chromosome5
Location5q31.2 (137890571 ~ 137911133) to Ensembl
Sequene Features : Isoforms 1, Variants 60, PTMs 30 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.negative regulation of apoptotic process
.protein targeting to mitochondrion
  + 2 more...
.unfolded protein binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
.ATP binding
.extracellular exosome
.mitochondrial nucleoid
.focal adhesion
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 60 30
2014-09-19protein level
1 50 30
2014-05-27protein level
1 50 30
2014-02-25protein level
1 50 20
2013-12-09protein level
1 41 20
2013-11-01protein level
1 40 16
2013-09-12protein level
1 40 12
2013-08-17protein level
1 40 12
2013-07-15protein level
1 28 11
2013-06-11protein level
1 28 11
2013-02-12protein level
1 12 13
2012-12-20protein level
1 12 13
2012-10-30protein level
1 13 13
2012-10-07protein level
1 13 13
2012-08-24protein level
1 8 13
2012-07-28protein level
1 8 13
2012-06-08protein level
1 15 13
2012-05-07protein level
1 15 13
2012-04-10protein level
1 15 13
2012-01-13protein level
1 16 12
2011-12-20protein level
1 16 12
2011-11-11protein level
1 16 11
2011-08-23protein level
1 16 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P38646-1
33 0 0 73634.5597
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-354932,EBI-389606 TP73  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.negative regulation of cardiac muscle cell proliferation
.protein tetramerization
  + 31 more...
.metal ion binding
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.intracellular membrane-bounded organelle
.cell junction
.cytosol
  + 5 more...
2 EBI-354932,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-354932,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-354932,EBI-347721 NELFB  
  .positive regulation of viral transcription
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.N/A .NELF complex
.cytoplasm
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland516
ascites953
bladder435
blood400
bone349
bone marrow451
brain350
cervix556
connective tissue228
ear186
embryonic tissue286
esophagus545
eye143
heart245
intestine288
kidney355
larynx127
liver287
lung256
lymph338
lymph node178
mammary gland588
mouth589
muscle423
nerve257
ovary108
pancreas126
parathyroid485
pharynx147
pituitary gland242
placenta226
prostate189
salivary gland98
skin436
spleen299
stomach135
testis261
thymus263
thyroid644
trachea212
umbilical cord145
uterus301
vascular425
Health State
TissuesTPM*
normal256
adrenal tumor395
bladder carcinoma227
breast (mammary gland) tumor816
cervical tumor666
chondrosarcoma301
colorectal tumor364
esophageal tumor637
gastrointestinal tumor455
germ cell tumor577
glioma195
head and neck tumor478
kidney tumor333
leukemia370
liver tumor395
lung tumor457
lymphoma373
non-neoplasia206
ovarian tumor144
pancreatic tumor161
primitive neuroectodermal tumor of the CNS370
prostate cancer202
retinoblastoma258
skin tumor454
soft tissue/muscle tissue tumor423
uterine tumor288
Developmental Stage
TissuesTPM*
adult291
embryoid body357
blastocyst292
neonate579
fetus235
infant382
juvenile809
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue69.8
adrenal gland166.3
appendix73.3
bone marrow123.8
cerebral cortex82.9
colon84.8
duodenum75.6
esophagus65.6
gallbladder63.1
heart muscle109.5
kidney125.3
liver110.7
lung50.6
lymph node69.1
ovary67.6
pancreas35.8
placenta63
prostate70.2
salivary gland51.7
skin52.9
small intestine65.2
spleen55
stomach60.2
testis58.2
thyroid gland124.1
urinary bladder69
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleLow
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600548, gene) Heat-shock 70-kd protein 9; HSPA9OMIM


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