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> Protein (NX_P38936)
Protein (NX_P38936)
Protein
Gene SymbolCDKN1A to neXtProt (NX_P38936)
DescriptionCyclin-dependent kinase inhibitor 1
Chromosome6
Location6p21.2 (36644305 ~ 36655116) to Ensembl
Sequene Features : Isoforms 1, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 37 8
2014-09-19protein level
1 29 8
2014-05-27protein level
1 29 8
2014-02-25protein level
1 29 8
2013-12-09protein level
1 26 8
2013-11-01protein level
1 25 7
2013-09-12protein level
1 25 7
2013-08-17protein level
1 25 7
2013-07-15protein level
1 21 7
2013-06-11protein level
1 21 7
2013-02-12protein level
1 13 7
2012-12-20protein level
1 13 7
2012-10-30protein level
1 13 7
2012-10-07protein level
1 13 7
2012-08-24protein level
1 13 7
2012-07-28protein level
1 13 7
2012-06-08protein level
1 22 7
2012-05-07protein level
1 19 7
2012-04-10protein level
1 19 7
2012-01-13protein level
1 16 7
2011-12-20protein level
1 16 7
2011-11-11protein level
1 16 7
2011-08-23protein level
1 16 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P38936-1
8 0 0 18107.9211
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-375077,EBI-374969 CDC45  
  .mitotic DNA replication preinitiation complex assembly
.positive regulation of G1/S transition of mitotic cell cycle
.DNA duplex unwinding
  + 10 more...
.3'-5' DNA helicase activity
.single-stranded DNA binding
.DNA replication origin binding
.chromatin binding
.replication fork protection complex
.DNA replication preinitiation complex
.centrosome
  + 4 more...
2 EBI-375077,EBI-1043945 CDK14  
  .regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
3 EBI-375077,EBI-375033 CCNE2  
  .cell division
.DNA replication initiation
.mitotic cell cycle
  + 3 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .cytosol
.nucleoplasm
4 EBI-375077,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
5 EBI-375077,EBI-295644 CDK4  
  .negative regulation of cell cycle arrest
.response to hyperoxia
.cell division
  + 20 more...
.cyclin binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.nuclear membrane
.tight junction
  + 7 more...
6 EBI-375077,EBI-358311 PCNA  
  .error-free translesion synthesis
.response to cadmium ion
.positive regulation of DNA replication
  + 24 more...
.DNA polymerase binding
.identical protein binding
.histone acetyltransferase binding
  + 7 more...
.PCNA-p21 complex
.extracellular exosome
.PCNA complex
  + 6 more...
7 EBI-375077,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
8 EBI-375077,EBI-457097 CCNA2  
  .cell division
.positive regulation of fibroblast proliferation
.positive regulation of transcription, DNA-templated
  + 11 more...
.N/A .cytoplasm
.nucleoplasm
.nucleus
  + 2 more...
9 EBI-375077,EBI-375001 CCND1  
  .negative regulation of cell cycle arrest
.response to UV-A
.mammary gland alveolus development
  + 34 more...
.proline-rich region binding
.histone deacetylase binding
.protein kinase binding
  + 5 more...
.transcriptional repressor complex
.membrane
.tight junction
  + 5 more...
10 EBI-375077,EBI-519526 CCNE1  
  .regulation of cell cycle
.cell division
.positive regulation of transcription, DNA-templated
  + 7 more...
.androgen receptor binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.transcription coactivator activity
.cytosol
.nucleoplasm
.nucleus
.cyclin-dependent protein kinase holoenzyme complex
11 EBI-375077,EBI-375096 CDK2  
  .cellular response to nitric oxide
.regulation of gene silencing
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 20 more...
.metal ion binding
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.Cajal body
.cytosol
.centrosome
  + 10 more...
12 EBI-375077,EBI-748789 CCND2  
  .cell division
.positive regulation of cyclin-dependent protein serine/threonine kinase activity
.cell cycle
.positive regulation of protein phosphorylation
.protein kinase binding .nuclear membrane
.cytosol
.nucleolus
  + 4 more...
13 EBI-375077,EBI-375013 CCND3  
  .cell division
.positive regulation of cyclin-dependent protein serine/threonine kinase activity
.T cell proliferation
  + 3 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase activity
.membrane
.cytoplasm
.nucleus
.cyclin-dependent protein kinase holoenzyme complex
14 EBI-375077,EBI-307486 SKP1  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
15 EBI-375077,EBI-375065 CCNA1  
  .cell division
.regulation of G2/M transition of mitotic cell cycle
.spermatogenesis
  + 7 more...
.N/A .microtubule cytoskeleton
.cytosol
.nucleoplasm
16 EBI-375077,EBI-1041567 CDK5  
  .positive regulation of actin cytoskeleton reorganization
.regulation of synaptic vesicle recycling
.negative regulation of neuron death
  + 63 more...
.tau-protein kinase activity
.ErbB-3 class receptor binding
.acetylcholine receptor activator activity
  + 6 more...
.postsynaptic membrane
.perikaryon
.neuronal cell body
  + 14 more...
17 EBI-375077,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
18 EBI-375077,EBI-456291 SKP2  
  .cellular response to cell-matrix adhesion
.regulation of cell cycle
.positive regulation of smooth muscle cell proliferation
  + 8 more...
.identical protein binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.aggresome
.cytosol
  + 4 more...
19 EBI-375077,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
20 EBI-375077,EBI-742397 TEX11  
  .chiasma assembly
.negative regulation of apoptotic process
.fertilization
  + 6 more...
.N/A .central element
21 EBI-375077,EBI-1054981 SIPA1  
  .negative regulation of cell cycle
.positive regulation of GTPase activity
.cellular response to water deprivation
  + 6 more...
.GTPase activator activity .perinuclear region of cytoplasm
.protein complex
.transport vesicle
  + 5 more...
22 EBI-375077,EBI-374862 CDC6  
  .positive regulation of chromosome segregation
.cell division
.positive regulation of cytokinesis
  + 11 more...
.kinase binding
.ATP binding
.chromatin binding
.nucleotide binding
.spindle midzone
.cytosol
.Golgi apparatus
  + 4 more...
23 EBI-375077,EBI-2120336 NABP2  
  .response to ionizing radiation
.mitotic cell cycle checkpoint
.cellular response to DNA damage stimulus
  + 2 more...
.single-stranded DNA binding .SOSS complex
.cytoplasm
.nucleoplasm
.nucleus
24 EBI-375077,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
25 EBI-375077,EBI-373524 MKRN1  
  .protein polyubiquitination .poly(A) RNA binding
.ligase activity
.zinc ion binding
  + 2 more...
.N/A
26 EBI-375077,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites652
bladder33
blood24
bone41
bone marrow82
brain32
cervix41
connective tissue93
ear248
embryonic tissue23
esophagus49
eye225
heart178
intestine137
kidney80
larynx85
liver112
lung719
lymph45
lymph node66
mammary gland158
mouth166
muscle75
nerve386
ovary78
pancreas248
parathyroid97
pharynx49
placenta166
prostate137
salivary gland148
skin370
stomach324
testis29
thymus100
thyroid128
trachea38
uterus146
vascular77
Health State
TissuesTPM*
normal127
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma36
colorectal tumor8
esophageal tumor57
gastrointestinal tumor413
germ cell tumor87
glioma177
head and neck tumor112
kidney tumor203
leukemia74
liver tumor166
lung tumor642
lymphoma69
non-neoplasia82
ovarian tumor144
pancreatic tumor247
primitive neuroectodermal tumor of the CNS86
prostate cancer163
retinoblastoma559
skin tumor119
soft tissue/muscle tissue tumor143
uterine tumor277
Developmental Stage
TissuesTPM*
adult164
embryoid body71
blastocyst81
neonate32
fetus5
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue105.5
adrenal gland59.8
appendix50.5
bone marrow39.3
cerebral cortex22.9
colon111.9
duodenum85.7
esophagus98
gallbladder124.8
heart muscle27.6
kidney17.9
liver65.1
lung44.7
lymph node15.1
ovary73.7
pancreas55.3
placenta42.4
prostate37.9
salivary gland9.3
skin40.8
small intestine94.9
spleen11
stomach36.2
testis26.9
thyroid gland44.4
urinary bladder97.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*116899, gene) Cyclin-dependent kinase inhibitor 1a; CDKN1AOMIM


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