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> Protein (NX_P39905)
Protein (NX_P39905)
Protein
Gene SymbolGDNF to neXtProt (NX_P39905)
DescriptionGlial cell line-derived neurotrophic factor
Chromosome5
Location5p13.2 (37812779 ~ 37839788) to Ensembl
Sequene Features : Isoforms 5, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of branching involved in ureteric bud morphogenesis
.positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
  + 28 more...
.protein homodimerization activity
.receptor binding
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 45 6
2014-09-19protein level
5 29 6
2014-05-27protein level
5 29 6
2014-02-25protein level
5 29 6
2013-12-09protein level
5 28 6
2013-11-01protein level
5 27 6
2013-09-12protein level
5 27 6
2013-08-17protein level
5 27 6
2013-07-15protein level
5 21 6
2013-06-11protein level
5 21 6
2013-02-12protein level
5 8 30
2012-12-20protein level
5 8 30
2012-10-30protein level
5 9 30
2012-10-07protein level
5 9 6
2012-08-24protein level
5 8 6
2012-07-28protein level
5 8 6
2012-06-08protein level
5 8 6
2012-05-07protein level
5 8 6
2012-04-10protein level
5 8 6
2012-01-13protein level
4 6 6
2011-12-20protein level
4 6 6
2011-11-11protein level
4 6 6
2011-08-23protein level
4 6 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P39905-1
0 7 0 23705.027
NX_P39905-2
0 5 0 20871.566
NX_P39905-3
0 8 0 25449.8535
NX_P39905-4
0 6 0 22616.3925
NX_P39905-5
1 4 0 18111.0879
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10207709,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain4
muscle18
ovary19
placenta7
skin23
Health State
TissuesTPM*
normal6
non-neoplasia20
ovarian tumor26
primitive neuroectodermal tumor of the CNS7
Developmental Stage
TissuesTPM*
adult4
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix1.5
colon2
duodenum1.2
ovary3.3
placenta4.3
prostate1.2
small intestine1.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#209880, phenotype) Central hypoventilation syndrome, congenital; CCHSOMIM
2(*600837, gene) Glial cell line-derived neurotrophic factor; GDNFOMIM
3(#613711, phenotype) Hirschsprung disease, susceptibility to, 3; HSCR3OMIM


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