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> Protein (NX_P40222)
Protein (NX_P40222)
Protein
Gene SymbolTXLNA to neXtProt (NX_P40222)
DescriptionAlpha-taxilin
Chromosome1
Location1p35.1 (32645287 ~ 32663886) to Ensembl
Sequene Features : Isoforms 1, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 54 4
2014-09-19protein level
1 43 4
2014-05-27protein level
1 43 4
2014-02-25protein level
1 43 4
2013-12-09protein level
1 33 4
2013-11-01protein level
1 30 3
2013-09-12protein level
1 30 3
2013-08-17protein level
1 30 3
2013-07-15protein level
1 19 3
2013-06-11protein level
1 19 3
2013-02-12protein level
1 11 4
2012-12-20protein level
1 11 4
2012-10-30protein level
1 13 4
2012-10-07protein level
1 13 4
2012-08-24protein level
1 12 4
2012-07-28protein level
1 12 4
2012-06-08protein level
1 20 4
2012-05-07protein level
1 16 4
2012-04-10protein level
1 16 4
2012-01-13protein level
1 11 4
2011-12-20protein level
1 11 4
2011-11-11protein level
1 11 4
2011-08-23protein level
1 11 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P40222-1
24 0 0 61853.0668
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359793,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-359793,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
3 EBI-359793,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
4 EBI-359793,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
5 EBI-359793,EBI-1054687 BTF3  
  .protein transport
.transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.in utero embryonic development
.poly(A) RNA binding .cytoplasm
.nucleus
6 EBI-359793,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
7 EBI-359793,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
8 EBI-359793,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
9 EBI-359793,EBI-749995 TCL1A  
  .stem cell maintenance
.multicellular organismal development
.N/A .pronucleus
.cell cortex
.endoplasmic reticulum
10 EBI-359793,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
11 EBI-359793,EBI-748597 CCDC67  
  .multi-ciliated epithelial cell differentiation
.de novo centriole assembly
.cell projection organization
.N/A .deuterosome
.cytoplasm
12 EBI-359793,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-359793,EBI-745426 PPFIA1  
  .negative regulation of establishment of protein localization to plasma membrane
.negative regulation of stress fiber assembly
.glutamate secretion
  + 4 more...
.signal transducer activity .presynaptic active zone
.focal adhesion
.cytosol
.cytoplasm
14 EBI-359793,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
15 EBI-359793,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
16 EBI-359793,EBI-712216 NACA  
  .positive regulation of cell proliferation involved in heart morphogenesis
.positive regulation of transcription from RNA polymerase II promoter involved in heart development
.negative regulation of transcription from RNA polymerase II promoter involved in heart development
  + 10 more...
.TBP-class protein binding
.transcription coactivator activity
.DNA binding
.extracellular exosome
.nascent polypeptide-associated complex
.cytoplasm
.nucleus
17 EBI-359793,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
18 EBI-359793,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
19 EBI-359793,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
20 EBI-359793,EBI-2558217 HAUS3  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.spindle
  + 2 more...
21 EBI-359793,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
22 EBI-359793,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
23 EBI-359793,EBI-6658186 LCA5  
  .photoreceptor cell maintenance
.intraciliary transport
.protein transport
.protein complex binding .cilium
.microtubule organizing center
.cytoplasm
24 EBI-359793,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
25 EBI-359793,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
26 EBI-359793,EBI-6116822 TXLNB  
  .N/A .N/A .cytoplasm
27 EBI-359793,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
28 EBI-359793,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
29 EBI-359793,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
30 EBI-359793,EBI-714194 STMN2  
  .cellular response to nerve growth factor stimulus
.positive regulation of microtubule depolymerization
.negative regulation of microtubule polymerization
  + 3 more...
.calcium-dependent protein binding
.tubulin binding
.perinuclear region of cytoplasm
.neuronal cell body
.neuron projection
  + 8 more...
31 EBI-359793,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
32 EBI-359793,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
33 EBI-359793,EBI-6137496 BTF3L4  
  .N/A .N/A .N/A
34 EBI-359793,EBI-2557388 NSMCE2  
  .cellular senescence
.cell division
.positive regulation of mitotic metaphase/anaphase transition
  + 7 more...
.SUMO transferase activity
.ligase activity
.zinc ion binding
.Smc5-Smc6 complex
.PML body
.nucleoplasm
  + 2 more...
35 EBI-359793,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
36 EBI-359793,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
37 EBI-359793,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
38 EBI-359793,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
39 EBI-359793,EBI-301024 EIF4ENIF1  
  .N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
40 EBI-359793,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
41 EBI-359793,EBI-1048743 HYPK  
  .N/A .N/A .cytoplasm
.nucleus
42 EBI-359793,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
43 EBI-359793,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
44 EBI-359793,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
45 EBI-359793,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
bladder33
blood8
bone55
bone marrow20
brain29
cervix82
connective tissue33
embryonic tissue84
eye28
heart67
intestine68
kidney37
larynx170
liver38
lung59
lymph45
lymph node22
mammary gland92
mouth45
muscle9
nerve64
ovary39
pancreas28
pharynx24
pituitary gland60
placenta10
prostate26
skin104
spleen18
stomach52
testis55
thymus12
thyroid21
umbilical cord145
uterus94
vascular58
Health State
TissuesTPM*
normal44
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma72
colorectal tumor44
gastrointestinal tumor59
germ cell tumor75
glioma111
head and neck tumor44
kidney tumor29
leukemia21
liver tumor72
lung tumor68
lymphoma27
non-neoplasia62
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma21
skin tumor135
soft tissue/muscle tissue tumor39
uterine tumor88
Developmental Stage
TissuesTPM*
adult54
embryoid body100
blastocyst146
neonate32
fetus55
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.7
adrenal gland20
appendix19.8
bone marrow9.6
cerebral cortex10
colon16.6
duodenum14.1
esophagus17.6
gallbladder19.6
heart muscle9.5
kidney14
liver12
lung19.1
lymph node20.2
ovary19
pancreas9.4
placenta15.2
prostate16
salivary gland14.9
skin25.6
small intestine12.2
spleen16.9
stomach15.8
testis24.9
thyroid gland18.1
urinary bladder20.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaHigh
ovaryLow
pancreasHigh
parathyroid glandLow
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608676, gene) Taxilin, alpha; TXLNAOMIM


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