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> Protein (NX_P40337)
Protein (NX_P40337)
Protein
Gene SymbolVHL to neXtProt (NX_P40337)
DescriptionVon Hippel-Lindau disease tumor suppressor
Chromosome3
Location3p25.3 (10182692 ~ 10193904) to Ensembl
Sequene Features : Isoforms 3, Variants 467, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to hypoxia
.negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 10 more...
.ubiquitin protein ligase activity
.enzyme binding
.transcription factor binding
.ubiquitin-protein transferase activity
.intermediate filament cytoskeleton
.VCB complex
.membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 467 1
2014-09-19protein level
3 432 1
2014-05-27protein level
3 428 1
2014-02-25protein level
3 344 1
2013-12-09protein level
3 340 1
2013-11-01protein level
3 340 1
2013-09-12protein level
3 340 1
2013-08-17protein level
3 340 1
2013-07-15protein level
3 340 0
2013-06-11protein level
3 340 0
2013-02-12protein level
3 340 0
2012-12-20protein level
3 337 0
2012-10-30protein level
3 338 0
2012-10-07protein level
3 338 0
2012-08-24protein level
3 338 0
2012-07-28protein level
3 339 0
2012-06-08protein level
3 139 0
2012-05-07protein level
3 139 0
2012-04-10protein level
3 139 0
2012-01-13protein level
3 139 0
2011-12-20protein level
3 139 0
2011-11-11protein level
3 139 0
2011-08-23protein level
3 139 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P40337-1
0 6 0 24137.8674
NX_P40337-2
0 5 0 19641.552
NX_P40337-3
1 5 0 18520.6039
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-301270,EBI-1765520 DGKI  
  .positive regulation of Ras protein signal transduction
.intracellular signal transduction
.platelet activation
  + 2 more...
.metal ion binding
.ATP binding
.GTPase inhibitor activity
  + 2 more...
.perinuclear region of cytoplasm
.synapse
.protein complex
  + 6 more...
2 EBI-301246,EBI-1220319 FN1  
  .leukocyte migration
.positive regulation of axon extension
.endodermal cell differentiation
  + 15 more...
.peptidase activator activity
.heparin binding
.collagen binding
  + 2 more...
.blood microparticle
.extracellular exosome
.platelet alpha granule lumen
  + 7 more...
3 EBI-301270,EBI-308084 GLI1  
  .negative regulation of canonical Wnt signaling pathway
.notochord regression
.digestive tract morphogenesis
  + 17 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 2 more...
.ciliary base
.ciliary tip
.primary cilium
  + 5 more...
4 EBI-301246,EBI-727668 TGM2  
  .salivary gland cavitation
.branching involved in salivary gland morphogenesis
.positive regulation of mitochondrial calcium ion concentration
  + 11 more...
.metal ion binding
.GTP binding
.protein-glutamine gamma-glutamyltransferase activity
.extracellular exosome
.intrinsic component of plasma membrane
.focal adhesion
  + 2 more...
5 EBI-301246,EBI-296739 GNB2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of gastrulation
.regulation of establishment of cell polarity
  + 30 more...
.poly(A) RNA binding
.protein homodimerization activity
.SH2 domain binding
  + 10 more...
.IRE1-RACK1-PP2A complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 11 more...
6 EBI-301246,EBI-295351 PRKCZ  
  .positive regulation of interleukin-10 secretion
.positive regulation of interleukin-13 secretion
.positive regulation of interleukin-5 secretion
  + 38 more...
.metal ion binding
.insulin receptor substrate binding
.potassium channel regulator activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical cortex
  + 17 more...
7 EBI-301246,EBI-456179 CUL2  
  .intrinsic apoptotic signaling pathway
.cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 5 more...
.ubiquitin protein ligase binding .Cul2-RING ubiquitin ligase complex
.cytosol
.nucleoplasm
8 EBI-301246,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
9 EBI-301246,EBI-1551681 RNF139  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of protein processing
.regulation of ER to Golgi vesicle-mediated transport
  + 5 more...
.ubiquitin-like protein transferase activity
.ligase activity
.zinc ion binding
  + 3 more...
.integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
10 EBI-301246,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
11 EBI-301246,EBI-78738 PRMT1  
  .negative regulation of megakaryocyte differentiation
.histone H4-R3 methylation
.neuron projection development
  + 7 more...
.poly(A) RNA binding
.histone methyltransferase activity (H4-R3 specific)
.identical protein binding
  + 5 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-301246,EBI-724997 FZR1  
  .negative regulation of cell aging
.protein K11-linked ubiquitination
.lens fiber cell differentiation
  + 13 more...
.N/A .nuclear membrane
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood8
bone13
brain16
cervix20
connective tissue6
ear124
embryonic tissue42
eye9
heart22
intestine21
kidney9
liver29
lung14
lymph22
lymph node11
mammary gland39
mouth75
muscle65
ovary9
pancreas14
parathyroid48
placenta60
prostate10
salivary gland148
skin4
spleen37
stomach20
testis6
thymus12
thyroid64
trachea38
umbilical cord145
uterus4
vascular77
Health State
TissuesTPM*
normal24
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor16
germ cell tumor34
glioma37
head and neck tumor37
leukemia10
liver tumor52
lung tumor9
lymphoma27
ovarian tumor13
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult26
embryoid body57
blastocyst48
fetus35
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.9
adrenal gland18
appendix29.9
bone marrow22.8
cerebral cortex23.6
colon20.6
duodenum19.4
esophagus14.2
gallbladder17
heart muscle7.2
kidney15.6
liver9.5
lung15.6
lymph node38.8
ovary17.9
pancreas8
placenta18.5
prostate18.9
salivary gland13.3
skin15.4
small intestine20
spleen29.8
stomach20.6
testis20.1
thyroid gland20.9
urinary bladder23.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#144700, phenotype) Renal cell carcinoma, nonpapillary; RCCOMIM
2(#171300, phenotype) PheochromocytomaOMIM
3(#193300, phenotype) Von hippel-lindau syndrome; VHLOMIM
4(#263400, phenotype) Erythrocytosis, familial, 2; ECYT2OMIM
5(*608537, gene) Vhl gene; VHLOMIM
6renal;hemangioma;pheochromocytoma;von Hippel-Lindau syndromeCGP


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