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> Protein (NX_P40763)
Protein (NX_P40763)
Protein
Gene SymbolSTAT3 to neXtProt (NX_P40763)
DescriptionSignal transducer and activator of transcription 3
Chromosome17
Location17q21.2 (40465342 ~ 40540586) to Ensembl
Sequene Features : Isoforms 3, Variants 119, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 119 16
2014-09-19protein level
2 84 16
2014-05-27protein level
2 84 16
2014-02-25protein level
2 84 15
2013-12-09protein level
2 81 15
2013-11-01protein level
2 79 11
2013-09-12protein level
2 79 11
2013-08-17protein level
2 79 11
2013-07-15protein level
2 62 7
2013-06-11protein level
2 62 7
2013-02-12protein level
2 35 10
2012-12-20protein level
2 33 10
2012-10-30protein level
2 35 10
2012-10-07protein level
2 35 5
2012-08-24protein level
2 26 5
2012-07-28protein level
2 26 5
2012-06-08protein level
2 33 5
2012-05-07protein level
2 33 5
2012-04-10protein level
2 33 5
2012-01-13protein level
2 31 5
2011-12-20protein level
2 31 5
2011-11-11protein level
2 29 6
2011-08-23protein level
2 29 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P40763-1
0 37 0 88011.1279
NX_P40763-2
1 36 0 87924.0961
NX_P40763-3
1 35 0 83073.0816
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-518675,EBI-2935583 SOX1  
  .forebrain neuron development
.ventral spinal cord interneuron specification
.regulation of transcription, DNA-templated
  + 4 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.core promoter sequence-specific DNA binding
.nucleus
2 EBI-518675,EBI-1046765 BCKDK  
  .phosphorylation
.branched-chain amino acid catabolic process
.cellular amino acid catabolic process
.protein phosphorylation
.[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
.kinase activity
.ATP binding
.protein serine/threonine kinase activity
.mitochondrial alpha-ketoglutarate dehydrogenase complex
.mitochondrion
3 EBI-518675,EBI-358684 MAP3K7  
  .negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
4 EBI-518675,EBI-6139214 DIRAS3  
  .small GTPase mediated signal transduction
.regulation of gene expression by genetic imprinting
.regulation of cyclin-dependent protein serine/threonine kinase activity
.GTP binding
.GTPase activity
.plasma membrane
5 EBI-518675,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
6 EBI-518675,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
7 EBI-518675,EBI-78539 PGR  
  .tertiary branching involved in mammary gland duct morphogenesis
.progesterone receptor signaling pathway
.regulation of epithelial cell proliferation
  + 8 more...
.ATPase binding
.enzyme binding
.zinc ion binding
  + 7 more...
.mitochondrial outer membrane
.nucleoplasm
8 EBI-518675,EBI-1542113 CAPN1  
  .receptor catabolic process
.extracellular matrix organization
.extracellular matrix disassembly
  + 2 more...
.calcium ion binding
.calcium-dependent cysteine-type endopeptidase activity
.extracellular exosome
.membrane
.focal adhesion
  + 3 more...
9 EBI-518675,EBI-2480756 RET  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.lymphocyte migration into lymphoid organs
.positive regulation of metanephric glomerulus development
  + 30 more...
.ATP binding
.calcium ion binding
.receptor activity
  + 2 more...
.membrane raft
.receptor complex
.intracellular membrane-bounded organelle
  + 4 more...
10 EBI-518675,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
11 EBI-518675,EBI-721550 NR4A1  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 13 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 2 more...
.nuclear membrane
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-518675,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
13 EBI-518675,EBI-719602 ECHS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.fatty acid beta-oxidation
.enoyl-CoA hydratase activity .extracellular exosome
.mitochondrial matrix
.mitochondrion
14 EBI-518675,EBI-750459 SRI  
  .negative regulation of transcription regulatory region DNA binding
.regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
  + 20 more...
.protein heterodimerization activity
.ion channel binding
.calcium ion binding
  + 4 more...
.extracellular exosome
.dendritic spine neck
.axon terminus
  + 11 more...
15 EBI-518675,EBI-1046676 CORO1A  
  .cellular response to interleukin-4
.early endosome to recycling endosome transport
.regulation of release of sequestered calcium ion into cytosol
  + 23 more...
.actin filament binding
.poly(A) RNA binding
.phosphatidylinositol 3-kinase binding
  + 6 more...
.extracellular exosome
.phagocytic vesicle
.protein complex
  + 12 more...
16 EBI-518675,EBI-1057697 STAT1  
  .negative regulation of metanephric nephron tubule epithelial cell differentiation
.metanephric mesenchymal cell differentiation
.metanephric mesenchymal cell proliferation involved in metanephros development
  + 37 more...
.protein homodimerization activity
.identical protein binding
.enzyme binding
  + 7 more...
.dendrite
.axon
.cytosol
  + 5 more...
17 EBI-518675,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
18 EBI-518675,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
19 EBI-518675,EBI-351206 RPS9  
  .positive regulation of translational fidelity
.cellular protein metabolic process
.viral transcription
  + 10 more...
.translation regulator activity
.poly(A) RNA binding
.rRNA binding
.structural constituent of ribosome
.extracellular exosome
.ribonucleoprotein complex
.cytosolic small ribosomal subunit
  + 7 more...
20 EBI-518675,EBI-2105445 BLK  
  .cellular response to peptide hormone stimulus
.B cell receptor signaling pathway
.innate immune response
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
21 EBI-518675,EBI-696657 BMX  
  .protein autophosphorylation
.innate immune response
.regulation of cell proliferation
  + 12 more...
.metal ion binding
.ATP binding
.signal transducer activity
  + 2 more...
.ruffle membrane
.extrinsic component of cytoplasmic side of plasma membrane
.cytosol
22 EBI-518675,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
23 EBI-518675,EBI-3921363 SULT2A1  
  .sulfation
.3'-phosphoadenosine 5'-phosphosulfate metabolic process
.small molecule metabolic process
  + 5 more...
.bile-salt sulfotransferase activity
.sulfotransferase activity
.cytosol
24 EBI-518675,EBI-1364 KHDRBS1  
  .positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
25 EBI-518675,EBI-711968 ECH1  
  .fatty acid beta-oxidation .isomerase activity
.receptor binding
.extracellular exosome
.membrane
.peroxisome
.mitochondrion
26 EBI-518675,EBI-530054 EZH2  
  .negative regulation of G1/S transition of mitotic cell cycle
.positive regulation of protein serine/threonine kinase activity
.protein localization to chromatin
  + 25 more...
.histone methyltransferase activity (H3-K27 specific)
.sequence-specific DNA binding
.histone methyltransferase activity
  + 7 more...
.pronucleus
.ESC/E(Z) complex
.cytoplasm
  + 3 more...
27 EBI-518675,EBI-372506 GADD45GIP1  
  .mitotic cell cycle arrest
.mitochondrial translational termination
.mitochondrial translational elongation
  + 4 more...
.N/A .mitochondrial matrix
.mitochondrion
.nucleus
28 EBI-518675,EBI-3940432 MORC4  
  .N/A .zinc ion binding .nucleoplasm
29 EBI-518675,EBI-720602 MRPS31  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 2 more...
.poly(A) RNA binding
.protein domain specific binding
.structural constituent of ribosome
.mitochondrial small ribosomal subunit
.mitochondrial inner membrane
.mitochondrion
.nucleolus
30 EBI-518675,EBI-1104509 BICD1  
  .negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
.regulation of proteinase activated receptor activity
.negative regulation of phospholipase C activity
  + 9 more...
.dynein binding
.dynactin binding
.proteinase activated receptor binding
  + 3 more...
.host cell viral assembly compartment
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 5 more...
31 EBI-518675,EBI-7331284 CSF3R  
  .amelogenesis
.neutrophil chemotaxis
.signal transduction
  + 2 more...
.cytokine receptor activity
.receptor activity
.integral component of plasma membrane
.extracellular region
32 EBI-518675,EBI-641642 GNL3  
  .positive regulation of pri-miRNA transcription from RNA polymerase II promoter
.ribosome biogenesis
.regulation of cell proliferation
  + 2 more...
.poly(A) RNA binding
.GTP binding
.GTPase activity
.membrane
.nucleolus
.nucleoplasm
  + 2 more...
33 EBI-518675,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
34 EBI-518675,EBI-3940481 OGDHL  
  .tricarboxylic acid cycle
.glycolytic process
.metal ion binding
.thiamine pyrophosphate binding
.oxoglutarate dehydrogenase (succinyl-transferring) activity
.oxoglutarate dehydrogenase complex
.mitochondrial matrix
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland121
ascites125
bladder234
blood212
bone27
bone marrow41
brain86
cervix164
connective tissue140
ear62
embryonic tissue178
esophagus49
eye71
heart67
intestine103
kidney80
larynx383
liver194
lung146
lymph node167
mammary gland145
mouth801
muscle84
nerve321
ovary216
pancreas145
pharynx171
pituitary gland60
placenta130
prostate89
salivary gland296
skin180
spleen524
stomach104
testis147
thymus363
thyroid193
tonsil293
trachea656
uterus172
vascular77
Health State
TissuesTPM*
normal129
adrenal tumor79
bladder carcinoma284
breast (mammary gland) tumor128
cervical tumor231
chondrosarcoma48
colorectal tumor142
esophageal tumor57
gastrointestinal tumor118
germ cell tumor155
glioma55
head and neck tumor560
kidney tumor72
leukemia116
liver tumor333
lung tumor204
non-neoplasia144
ovarian tumor275
pancreatic tumor180
primitive neuroectodermal tumor of the CNS78
prostate cancer48
skin tumor159
soft tissue/muscle tissue tumor95
uterine tumor244
Developmental Stage
TissuesTPM*
adult169
embryoid body242
blastocyst179
neonate32
fetus95
infant85
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue99.2
adrenal gland58.5
appendix86.5
bone marrow79.6
cerebral cortex34.4
colon61.2
duodenum47.5
esophagus79.4
gallbladder91.3
heart muscle43.3
kidney53.8
liver62.4
lung87.6
lymph node63.5
ovary37.5
pancreas33.9
placenta52.4
prostate61.7
salivary gland34.7
skin51.1
small intestine59.5
spleen73.1
stomach49.8
testis35.9
thyroid gland53.5
urinary bladder74.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*102582, gene) Signal transducer and activator of transcription 3; STAT3OMIM
2(#147060, phenotype) Hyper-ige recurrent infection syndrome, autosomal dominantOMIM


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