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> Protein (NX_P40818)
Protein (NX_P40818)
Protein
Gene SymbolUSP8 to neXtProt (NX_P40818)
DescriptionUbiquitin carboxyl-terminal hydrolase 8
Chromosome15
Location15q21.2 (50716577 ~ 50793280) to Ensembl
Sequene Features : Isoforms 2, Variants 120, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 6 more...
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.extrinsic component of endosome membrane
.midbody
.extrinsic component of plasma membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 120 9
2014-09-19protein level
2 93 9
2014-05-27protein level
2 92 9
2014-02-25protein level
1 92 9
2013-12-09protein level
1 71 9
2013-11-01protein level
1 69 9
2013-09-12protein level
1 69 9
2013-08-17protein level
1 69 9
2013-07-15protein level
1 50 9
2013-06-11protein level
1 50 9
2013-02-12protein level
1 30 9
2012-12-20protein level
1 27 9
2012-10-30protein level
1 35 9
2012-10-07protein level
1 35 9
2012-08-24protein level
1 33 9
2012-07-28protein level
1 33 9
2012-06-08protein level
1 37 9
2012-05-07protein level
1 29 9
2012-04-10protein level
1 29 9
2012-01-13protein level
1 24 9
2011-12-20protein level
1 24 9
2011-11-11protein level
1 24 6
2011-08-23protein level
1 24 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P40818-1
6 43 0 127443.6515
NX_P40818-2
1 43 0 115008.2438
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1050865,EBI-742698 NBR1  
  .protein oligomerization
.negative regulation of osteoblast differentiation
.regulation of stress-activated MAPK cascade
  + 2 more...
.mitogen-activated protein kinase binding
.ubiquitin binding
.zinc ion binding
.extracellular exosome
.M band
.cytoplasmic vesicle
  + 6 more...
2 EBI-1050865,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
3 EBI-1050865,EBI-2118090 CHMP1B  
  .regulation of mitotic spindle assembly
.cell division
.establishment of protein localization
  + 7 more...
.protein domain specific binding .extracellular exosome
.late endosome membrane
.membrane coat
  + 2 more...
4 EBI-1050865,EBI-1221015 CHMP4C  
  .positive regulation of viral release from host cell
.regulation of mitotic spindle assembly
.ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
  + 13 more...
.protein homodimerization activity .Flemming body
.extracellular exosome
.late endosome membrane
  + 2 more...
5 EBI-1050865,EBI-447470 EPAS1  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.iron ion homeostasis
  + 18 more...
.protein heterodimerization activity
.histone acetyltransferase binding
.transcription factor binding
  + 4 more...
.nuclear speck
.cytosol
.transcription factor complex
  + 2 more...
6 EBI-1050865,EBI-1057156 CHMP1A  
  .regulation of mitotic spindle assembly
.cell division
.negative regulation of transcription, DNA-templated
  + 12 more...
.protein homodimerization activity
.protein domain specific binding
.zinc ion binding
.metallopeptidase activity
.extracellular exosome
.nuclear matrix
.endomembrane system
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites75
bladder133
blood81
bone13
bone marrow123
brain43
cervix61
connective tissue33
ear310
embryonic tissue37
esophagus99
eye38
heart11
intestine34
kidney99
larynx42
liver116
lung68
lymph22
lymph node77
mammary gland46
mouth120
muscle103
ovary98
pancreas65
parathyroid97
pharynx73
pituitary gland60
placenta45
prostate31
salivary gland148
skin85
stomach41
testis105
thymus12
thyroid21
trachea96
umbilical cord72
uterus86
vascular58
Health State
TissuesTPM*
normal68
adrenal tumor158
bladder carcinoma227
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma36
colorectal tumor35
esophageal tumor115
gastrointestinal tumor67
germ cell tumor26
glioma37
head and neck tumor82
kidney tumor29
leukemia116
liver tumor83
lung tumor38
lymphoma13
non-neoplasia41
ovarian tumor105
pancreatic tumor47
primitive neuroectodermal tumor of the CNS23
prostate cancer19
skin tumor39
soft tissue/muscle tissue tumor23
uterine tumor122
Developmental Stage
TissuesTPM*
adult52
embryoid body57
blastocyst32
neonate96
fetus91
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.8
adrenal gland25.5
appendix26.2
bone marrow21.7
cerebral cortex18.1
colon25
duodenum25.9
esophagus22.7
gallbladder22.3
heart muscle15.4
kidney24.1
liver18.6
lung19.6
lymph node26
ovary20.9
pancreas11.3
placenta22.8
prostate20.1
salivary gland17.1
skin18.5
small intestine24.6
spleen19.9
stomach22.5
testis36.5
thyroid gland29.6
urinary bladder29.8
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastLow
bronchusLow
cerebellumLow
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
fallopian tubeLow
gallbladderLow
kidneyLow
lungLow
pancreasLow
placentaMedium
prostateLow
rectumLow
skeletal muscleHigh
small intestineLow
soft tissue 1Low
soft tissue 2Low
stomach 1Low
stomach 2Low
testisHigh
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603158, gene) Ubiquitin-specific protease 8; USP8OMIM


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