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> Protein (NX_P40939)
Protein (NX_P40939)
Protein
Gene SymbolHADHA to neXtProt (NX_P40939)
DescriptionTrifunctional enzyme subunit alpha, mitochondrial
Chromosome2
Location2p23.3 (26413504 ~ 26467594) to Ensembl
Sequene Features : Isoforms 2, Variants 102, PTMs 53 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.glycerophospholipid biosynthetic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 5 more...
.NAD binding
.long-chain-3-hydroxyacyl-CoA dehydrogenase activity
.long-chain-enoyl-CoA hydratase activity
  + 4 more...
.mitochondrial nucleoid
.mitochondrial fatty acid beta-oxidation multienzyme complex
.mitochondrial inner membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 102 53
2014-09-19protein level
2 78 53
2014-05-27protein level
2 77 53
2014-02-25protein level
1 74 29
2013-12-09protein level
1 53 29
2013-11-01protein level
1 52 27
2013-09-12protein level
1 52 12
2013-08-17protein level
1 52 12
2013-07-15protein level
1 35 12
2013-06-11protein level
1 35 12
2013-02-12protein level
1 21 14
2012-12-20protein level
1 19 14
2012-10-30protein level
1 24 14
2012-10-07protein level
1 24 14
2012-08-24protein level
1 19 14
2012-07-28protein level
1 19 14
2012-06-08protein level
1 28 14
2012-05-07protein level
1 28 14
2012-04-10protein level
1 28 14
2012-01-13protein level
1 22 14
2011-12-20protein level
1 22 14
2011-11-11protein level
1 22 14
2011-08-23protein level
1 22 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P40939-1
27 8 0 82946.6341
NX_P40939-2
2 8 0 28348.3075
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356720,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-356720,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
3 EBI-356720,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
4 EBI-356720,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland212
ascites125
bladder435
blood294
bone153
bone marrow410
brain157
cervix309
connective tissue134
ear62
embryonic tissue206
esophagus198
eye244
heart390
intestine461
kidney298
larynx809
liver194
lung253
lymph564
lymph node233
mammary gland343
muscle441
nerve193
ovary285
pancreas178
parathyroid97
pharynx98
pituitary gland181
placenta219
prostate232
salivary gland296
skin346
spleen56
stomach135
testis225
thymus288
thyroid279
tonsil176
trachea96
umbilical cord217
uterus435
vascular174
Health State
TissuesTPM*
normal202
adrenal tumor79
bladder carcinoma341
breast (mammary gland) tumor300
cervical tumor434
chondrosarcoma277
colorectal tumor497
esophageal tumor231
gastrointestinal tumor185
germ cell tumor224
glioma279
head and neck tumor246
kidney tumor290
leukemia529
liver tumor239
lung tumor350
lymphoma457
non-neoplasia206
ovarian tumor249
pancreatic tumor238
primitive neuroectodermal tumor of the CNS338
prostate cancer240
retinoblastoma452
skin tumor374
soft tissue/muscle tissue tumor343
uterine tumor743
Developmental Stage
TissuesTPM*
adult271
embryoid body185
blastocyst260
neonate514
fetus245
infant255
juvenile233
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue91.7
adrenal gland91.3
appendix52.9
bone marrow51.5
cerebral cortex43.9
colon106.7
duodenum163.7
esophagus73.2
gallbladder52.3
heart muscle115.3
kidney96.9
liver101.8
lung51
lymph node57.7
ovary76.7
pancreas38.7
placenta52.4
prostate53.9
salivary gland49.5
skin68.1
small intestine147.1
spleen52.2
stomach57.4
testis52.3
thyroid gland66
urinary bladder66.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaLow
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600890, gene) Hydroxyacyl-coa dehydrogenase/3-ketoacyl-coa thiolase/enoyl-coa hydratase,OMIM
2(#609015, phenotype) Trifunctional protein deficiencyOMIM
3(#609016, phenotype) Long-chain 3-hydroxyacyl-coa dehydrogenase deficiencyOMIM


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