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> Protein (NX_P41182)
Protein (NX_P41182)
Protein
Gene SymbolBCL6 to neXtProt (NX_P41182)
DescriptionB-cell lymphoma 6 protein
Chromosome3
Location3q27.3 (187439165 ~ 187463515) to Ensembl
Sequene Features : Isoforms 2, Variants 121, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cellular senescence
.positive regulation of cellular component movement
.regulation of immune response
  + 32 more...
.metal ion binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 4 more...
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 121 4
2014-09-19protein level
2 95 4
2014-05-27protein level
2 95 4
2014-02-25protein level
2 95 4
2013-12-09protein level
2 83 4
2013-11-01protein level
2 83 4
2013-09-12protein level
2 83 3
2013-08-17protein level
2 83 3
2013-07-15protein level
2 52 3
2013-06-11protein level
2 52 3
2013-02-12protein level
2 28 4
2012-12-20protein level
2 28 4
2012-10-30protein level
2 28 4
2012-10-07protein level
2 28 2
2012-08-24protein level
2 15 2
2012-07-28protein level
2 15 2
2012-06-08protein level
2 20 2
2012-05-07protein level
2 20 2
2012-04-10protein level
2 20 2
2012-01-13protein level
1 17 2
2011-12-20protein level
1 17 0
2011-11-11protein level
1 17 0
2011-08-23protein level
1 17 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P41182-1
4 29 2 78795.2359
NX_P41182-2
1 29 2 72320.28
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-765407,EBI-740434 ZBTB7B  
  .cell differentiation
.positive regulation of gene expression
.ectoderm development
  + 3 more...
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
2 EBI-765407,EBI-10196832 LIMS3L  
  .N/A .zinc ion binding .N/A
3 EBI-765407,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
4 EBI-765407,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
5 EBI-765407,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
6 EBI-765407,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
7 EBI-765407,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
8 EBI-765407,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
9 EBI-765407,EBI-714918 CUTC  
  .transmembrane transport
.copper ion homeostasis
.protein tetramerization
  + 2 more...
.copper ion binding .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
10 EBI-765407,EBI-765444 HDAC9  
  .positive regulation of cell migration involved in sprouting angiogenesis
.histone H4 deacetylation
.histone H3 deacetylation
  + 13 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 9 more...
.histone methyltransferase complex
.cytoplasm
.transcription factor complex
  + 3 more...
11 EBI-765407,EBI-765834 ZMYND8  
  .negative regulation of transcription from RNA polymerase II promoter .repressing transcription factor binding
.zinc ion binding
.RNA polymerase II transcription corepressor activity
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland30
bladder100
blood155
bone13
brain84
cervix20
connective tissue73
embryonic tissue23
eye43
heart89
intestine12
kidney9
larynx298
liver24
lung53
lymph22
lymph node178
mammary gland72
mouth105
muscle18
nerve257
ovary68
pancreas51
parathyroid48
pituitary gland181
placenta24
prostate84
skin9
spleen18
stomach52
testis55
thymus175
trachea115
uterus81
vascular19
Health State
TissuesTPM*
normal59
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma24
colorectal tumor8
gastrointestinal tumor42
germ cell tumor11
glioma65
head and neck tumor104
leukemia190
liver tumor41
lung tumor58
lymphoma13
non-neoplasia113
ovarian tumor78
pancreatic tumor85
primitive neuroectodermal tumor of the CNS7
prostate cancer19
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult74
embryoid body14
blastocyst48
neonate32
fetus59
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue94.7
adrenal gland30.9
appendix56.5
bone marrow71.6
cerebral cortex28.5
colon12.7
duodenum6.7
esophagus37.7
gallbladder46.5
heart muscle23.3
kidney12.4
liver23.2
lung34.9
lymph node50.8
ovary42
pancreas14.9
placenta17.5
prostate17.1
salivary gland25.8
skin62.6
small intestine7.3
spleen32.5
stomach9.2
testis18.1
thyroid gland21.2
urinary bladder33.9
Tissues
TissuesExpression level
appendixMedium
bone marrowHigh
breastLow
bronchusMedium
lymph nodeHigh
nasopharynxMedium
placentaMedium
skin 1Low
skin 2Low
spleenMedium
tonsilHigh
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*109565, gene) B-cell lymphoma 6; BCL6OMIM
2non-Hodgkin lymphoma;chronic lymphatic leukemiaCGP


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