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> Protein (NX_P41212)
Protein (NX_P41212)
Protein
Gene SymbolETV6 to neXtProt (NX_P41212)
DescriptionTranscription factor ETV6
Chromosome12
Location12p13.2 (11802788 ~ 12048336) to Ensembl
Sequene Features : Isoforms 1, Variants 92, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.hematopoietic stem cell proliferation
.cell differentiation
.transcription from RNA polymerase II promoter
  + 2 more...
.protein domain specific binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 4 more...
.cytoplasm
.nucleolus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 92 10
2014-09-19protein level
1 73 10
2014-05-27protein level
1 73 10
2014-02-25protein level
1 73 10
2013-12-09protein level
1 61 10
2013-11-01protein level
1 58 10
2013-09-12protein level
1 58 10
2013-08-17protein level
1 58 10
2013-07-15protein level
1 42 10
2013-06-11protein level
1 42 10
2013-02-12protein level
1 17 7
2012-12-20protein level
1 17 7
2012-10-30protein level
1 21 7
2012-10-07protein level
1 21 7
2012-08-24protein level
1 21 7
2012-07-28protein level
1 21 7
2012-06-08protein level
1 27 7
2012-05-07protein level
1 16 7
2012-04-10protein level
1 16 7
2012-01-13protein level
1 10 7
2011-12-20protein level
1 10 7
2011-11-11protein level
1 10 7
2011-08-23protein level
1 10 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P41212-1
19 0 0 52966.4612
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1372759,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
2 EBI-1372759,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
3 EBI-1372759,EBI-765476 HDAC9  
  .positive regulation of cell migration involved in sprouting angiogenesis
.histone H4 deacetylation
.histone H3 deacetylation
  + 13 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 9 more...
.histone methyltransferase complex
.cytoplasm
.transcription factor complex
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder66
blood40
bone41
bone marrow20
brain3
cervix61
connective tissue13
ear186
embryonic tissue28
eye43
heart22
intestine68
kidney47
larynx42
liver19
lung74
lymph node122
mammary gland119
mouth60
muscle9
ovary29
pancreas42
parathyroid48
pharynx24
pituitary gland60
placenta49
prostate26
skin18
stomach31
testis6
thymus37
trachea19
uterus51
vascular19
Health State
TissuesTPM*
normal39
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor42
chondrosarcoma60
colorectal tumor53
gastrointestinal tumor16
germ cell tumor15
glioma18
head and neck tumor37
kidney tumor72
leukemia95
liver tumor20
lung tumor19
lymphoma13
non-neoplasia10
ovarian tumor26
pancreatic tumor28
prostate cancer28
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor99
Developmental Stage
TissuesTPM*
adult49
embryoid body57
blastocyst32
fetus70
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.2
adrenal gland7.1
appendix18.2
bone marrow25.2
cerebral cortex2.9
colon11.3
duodenum7.1
esophagus9
gallbladder13.3
heart muscle3.6
kidney4.5
liver3.3
lung8.9
lymph node15.6
ovary3.5
pancreas4.9
placenta7.3
prostate6.8
salivary gland26.9
skin14
small intestine7.7
spleen15.2
stomach8.5
testis4
thyroid gland7.5
urinary bladder15.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#131440, phenotype) Myeloproliferative disorder, chronic, with eosinophiliaOMIM
2(*600618, gene) Ets variant gene 6; ETV6OMIM
3(#601626, phenotype) Leukemia, acute myeloid; AMLOMIM
4congenital fibrosarcoma;multiple leukemia and lymphoma;secretory breast;myelodysplastic syndrome;acute lymphocytic leukemiaCGP


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