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> Protein (NX_P41240)
Protein (NX_P41240)
Protein
Gene SymbolCSK to neXtProt (NX_P41240)
DescriptionTyrosine-protein kinase CSK
Chromosome15
Location15q24.1 (75074398 ~ 75095539) to Ensembl
Sequene Features : Isoforms 1, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to peptide hormone stimulus
.negative regulation of ERK1 and ERK2 cascade
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 26 more...
.identical protein binding
.protein C-terminus binding
.ATP binding
  + 3 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 43 9
2014-09-19protein level
1 31 9
2014-05-27protein level
1 31 9
2014-02-25protein level
1 31 9
2013-12-09protein level
1 30 9
2013-11-01protein level
1 28 8
2013-09-12protein level
1 28 8
2013-08-17protein level
1 28 8
2013-07-15protein level
1 20 4
2013-06-11protein level
1 20 4
2013-02-12protein level
1 11 4
2012-12-20protein level
1 11 4
2012-10-30protein level
1 11 4
2012-10-07protein level
1 11 4
2012-08-24protein level
1 10 4
2012-07-28protein level
1 10 4
2012-06-08protein level
1 13 4
2012-05-07protein level
1 9 4
2012-04-10protein level
1 9 4
2012-01-13protein level
1 8 4
2011-12-20protein level
1 8 4
2011-11-11protein level
1 8 4
2011-08-23protein level
1 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P41240-1
23 0 1 50671.5888
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1380630,EBI-475981 IGF1R  
  .positive regulation of steroid hormone biosynthetic process
.prostate gland epithelium morphogenesis
.negative regulation of protein kinase B signaling
  + 30 more...
.insulin receptor substrate binding
.insulin binding
.phosphatidylinositol 3-kinase binding
  + 7 more...
.receptor complex
.intracellular membrane-bounded organelle
.neuron projection
  + 4 more...
2 EBI-1380630,EBI-1341 PTPRC  
  .positive regulation of stem cell proliferation
.positive regulation of hematopoietic stem cell migration
.regulation of cell cycle
  + 24 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.membrane raft
.membrane
  + 5 more...
3 EBI-1380630,EBI-702209 PXN  
  .growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood392
bone69
bone marrow82
brain32
cervix103
connective tissue40
embryonic tissue51
eye43
heart11
intestine99
kidney18
larynx85
liver73
lung83
lymph248
lymph node256
mammary gland72
mouth15
ovary59
pancreas70
pituitary gland60
placenta31
prostate84
salivary gland296
skin204
spleen412
stomach62
testis64
thymus112
thyroid42
tonsil646
trachea19
uterus34
vascular38
Health State
TissuesTPM*
normal60
bladder carcinoma56
breast (mammary gland) tumor118
cervical tumor28
chondrosarcoma72
colorectal tumor71
gastrointestinal tumor59
germ cell tumor60
glioma93
head and neck tumor67
kidney tumor58
leukemia296
liver tumor135
lung tumor97
lymphoma235
non-neoplasia72
ovarian tumor26
pancreatic tumor133
primitive neuroectodermal tumor of the CNS86
prostate cancer96
retinoblastoma64
skin tumor311
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult54
embryoid body42
blastocyst32
neonate32
fetus41
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.7
adrenal gland16.1
appendix96.1
bone marrow39.4
cerebral cortex15.5
colon29.4
duodenum34.8
esophagus58.3
gallbladder27
heart muscle22.9
kidney13.4
liver16.8
lung33.6
lymph node166.1
ovary18.2
pancreas8.9
placenta21.4
prostate19.5
salivary gland23.7
skin29.7
small intestine37.6
spleen111.6
stomach35.2
testis22.3
thyroid gland15.2
urinary bladder45.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*124095, gene) Cytoplasmic tyrosine kinase; CSKOMIM


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