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> Protein (NX_P41743)
Protein (NX_P41743)
Protein
Gene SymbolPRKCI to neXtProt (NX_P41743)
DescriptionProtein kinase C iota type
Chromosome3
Location3q26.2 (169940153 ~ 170023769) to Ensembl
Sequene Features : Isoforms 1, Variants 78, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 78 13
2014-09-19protein level
1 60 13
2014-05-27protein level
1 60 13
2014-02-25protein level
1 60 13
2013-12-09protein level
1 52 13
2013-11-01protein level
1 50 13
2013-09-12protein level
1 50 13
2013-08-17protein level
1 50 13
2013-07-15protein level
1 30 13
2013-06-11protein level
1 30 13
2013-02-12protein level
1 14 12
2012-12-20protein level
1 15 12
2012-10-30protein level
1 20 12
2012-10-07protein level
1 20 12
2012-08-24protein level
1 18 12
2012-07-28protein level
1 18 12
2012-06-08protein level
1 30 12
2012-05-07protein level
1 22 12
2012-04-10protein level
1 22 12
2012-01-13protein level
1 22 12
2011-12-20protein level
1 22 12
2011-11-11protein level
1 20 5
2011-08-23protein level
1 20 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P41743-1
22 0 1 68218.156
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-286199,EBI-6124081 SOX2  
  .neuronal stem cell maintenance
.negative regulation of canonical Wnt signaling pathway
.response to growth factor
  + 44 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.miRNA binding
  + 5 more...
.nuclear transcription factor complex
.cytosol
.cytoplasm
  + 3 more...
2 EBI-286199,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
3 EBI-286199,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
4 EBI-286199,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
5 EBI-286199,EBI-295351 PRKCZ  
  .positive regulation of interleukin-10 secretion
.positive regulation of interleukin-13 secretion
.positive regulation of interleukin-5 secretion
  + 38 more...
.metal ion binding
.insulin receptor substrate binding
.potassium channel regulator activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical cortex
  + 17 more...
6 EBI-286199,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
7 EBI-286199,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
8 EBI-286199,EBI-81968 PARD3  
  .establishment of epithelial cell polarity
.tight junction assembly
.regulation of cellular localization
  + 18 more...
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.apical part of cell
.axonal growth cone
.protein complex
  + 11 more...
9 EBI-286199,EBI-302319 MARK4  
  .positive regulation of programmed cell death
.nervous system development
.organelle organization
  + 3 more...
.tau-protein kinase activity
.ubiquitin binding
.gamma-tubulin binding
  + 3 more...
.neuron projection
.ciliary basal body
.microtubule cytoskeleton
  + 3 more...
10 EBI-286199,EBI-295417 PARD6G  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 2 more...
.N/A .protein complex
.tight junction
.plasma membrane
.cytosol
11 EBI-286199,EBI-295391 PARD6B  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 7 more...
.N/A .extracellular exosome
.apical part of cell
.protein complex
  + 6 more...
12 EBI-286199,EBI-81876 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bladder133
blood8
bone27
bone marrow82
brain20
cervix41
connective tissue46
ear62
embryonic tissue79
eye47
heart33
intestine25
kidney28
liver24
lung32
lymph22
lymph node66
mammary gland39
mouth15
muscle56
ovary19
pancreas37
pharynx24
pituitary gland181
placenta14
prostate47
skin4
spleen37
stomach52
testis45
thyroid21
uterus25
Health State
TissuesTPM*
normal28
bladder carcinoma170
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma48
colorectal tumor26
gastrointestinal tumor50
germ cell tumor41
glioma18
head and neck tumor14
leukemia31
liver tumor31
lung tumor9
lymphoma13
non-neoplasia62
pancreatic tumor57
prostate cancer57
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult31
embryoid body42
blastocyst146
fetus37
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.8
adrenal gland7.6
appendix7.9
bone marrow3.3
cerebral cortex10.7
colon14.6
duodenum15.7
esophagus16
gallbladder13.5
heart muscle6
kidney12.8
liver4.7
lung18.2
lymph node6.1
ovary13.3
pancreas3.1
placenta10.3
prostate20.4
salivary gland15.5
skin16
small intestine12.9
spleen5.4
stomach37.2
testis15.6
thyroid gland27.7
urinary bladder18.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600539, gene) Protein kinase c, iota form; PRKCIOMIM


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