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> Protein (NX_P42224)
Protein (NX_P42224)
Protein
Gene SymbolSTAT1 to neXtProt (NX_P42224)
DescriptionSignal transducer and activator of transcription 1-alpha/beta
Chromosome2
Location2q32.2 (191829084 ~ 191885686) to Ensembl
Sequene Features : Isoforms 2, Variants 116, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of metanephric nephron tubule epithelial cell differentiation
.metanephric mesenchymal cell differentiation
.metanephric mesenchymal cell proliferation involved in metanephros development
  + 37 more...
.protein homodimerization activity
.identical protein binding
.enzyme binding
  + 7 more...
.dendrite
.axon
.cytosol
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 116 10
2014-09-19protein level
2 86 10
2014-05-27protein level
2 85 10
2014-02-25protein level
2 85 9
2013-12-09protein level
2 84 7
2013-11-01protein level
2 84 7
2013-09-12protein level
2 84 7
2013-08-17protein level
2 84 7
2013-07-15protein level
2 61 5
2013-06-11protein level
2 61 5
2013-02-12protein level
2 39 6
2012-12-20protein level
2 38 6
2012-10-30protein level
2 40 6
2012-10-07protein level
2 38 4
2012-08-24protein level
2 28 4
2012-07-28protein level
2 28 4
2012-06-08protein level
2 37 4
2012-05-07protein level
2 36 4
2012-04-10protein level
2 36 4
2012-01-13protein level
2 33 4
2011-12-20protein level
2 33 4
2011-11-11protein level
2 33 3
2011-08-23protein level
2 18 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P42224-1
3 34 1 87279.2713
NX_P42224-2
1 34 1 82990.2751
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1057697,EBI-995350 DDX58  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 17 more...
.identical protein binding
.zinc ion binding
.ATP binding
  + 4 more...
.ruffle membrane
.actin cytoskeleton
.tight junction
  + 2 more...
2 EBI-1057697,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-1057697,EBI-852851 FOS  
  .cellular response to calcium ion
.SMAD protein signal transduction
.response to cAMP
  + 44 more...
.R-SMAD binding
.transcription regulatory region DNA binding
.transcription factor binding
  + 3 more...
.neuron projection
.membrane
.cytosol
  + 4 more...
4 EBI-1057697,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
5 EBI-1057697,EBI-1030755 IFNGR1  
  .regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
.cytokine-mediated signaling pathway
  + 2 more...
.interferon-gamma receptor activity
.cytokine receptor activity
.vesicle
.dendrite
.integral component of membrane
  + 4 more...
6 EBI-1057697,EBI-78598 RXRA  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.regulation of branching involved in prostate gland morphogenesis
.secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
  + 22 more...
.protein heterodimerization activity
.retinoic acid-responsive element binding
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.receptor complex
.nucleoplasm
  + 2 more...
7 EBI-1057697,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
8 EBI-1057697,EBI-1546963 STAT2  
  .activation of mitophagy in response to mitochondrial depolarization
.regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
  + 7 more...
.identical protein binding
.signal transducer activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
9 EBI-1057697,EBI-448924 E2F1  
  .regulation of G1/S transition of mitotic cell cycle
.lens fiber cell apoptotic process
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.Rb-E2F complex
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-1057697,EBI-1054396 OTUD4  
  .protein K48-linked deubiquitination .poly(A) RNA binding
.ubiquitin-specific protease activity
.N/A
11 EBI-1057697,EBI-350322 DDB1  
  .positive regulation of viral release from host cell
.regulation of mitotic cell cycle phase transition
.UV-damage excision repair
  + 14 more...
.damaged DNA binding
.DNA binding
.Cul4-RING E3 ubiquitin ligase complex
.extracellular exosome
.Cul4B-RING E3 ubiquitin ligase complex
  + 5 more...
12 EBI-1057697,EBI-995373 MAVS  
  .regulation of peroxisome organization
.positive regulation of IP-10 production
.positive regulation of chemokine (C-C motif) ligand 5 production
  + 22 more...
.CARD domain binding
.protein kinase binding
.signal transducer activity
.mitochondrial membrane
.integral component of membrane
.peroxisomal membrane
  + 2 more...
13 EBI-1057697,EBI-750700 EIF1AD  
  .N/A .translation initiation factor activity .intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites100
bladder368
blood155
bone111
bone marrow143
brain127
cervix144
connective tissue295
embryonic tissue93
esophagus49
eye86
heart55
intestine129
kidney137
larynx85
liver155
lung77
lymph45
lymph node122
mammary gland119
mouth151
muscle56
nerve128
ovary88
pancreas60
pituitary gland60
placenta102
prostate73
salivary gland49
skin256
spleen318
stomach219
testis172
thymus188
thyroid193
trachea695
umbilical cord435
uterus486
vascular96
Health State
TissuesTPM*
normal128
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor118
cervical tumor57
chondrosarcoma84
colorectal tumor151
esophageal tumor57
gastrointestinal tumor202
germ cell tumor129
glioma65
head and neck tumor134
kidney tumor217
leukemia74
liver tumor145
lung tumor48
lymphoma124
non-neoplasia300
ovarian tumor105
pancreatic tumor95
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma43
skin tumor287
soft tissue/muscle tissue tumor183
uterine tumor765
Developmental Stage
TissuesTPM*
adult167
embryoid body171
blastocyst97
neonate193
fetus17
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.6
adrenal gland44.1
appendix133.7
bone marrow33
cerebral cortex42
colon50.7
duodenum53.3
esophagus41.7
gallbladder80
heart muscle30.3
kidney42.1
liver43.8
lung67.1
lymph node165
ovary34.6
pancreas22.5
placenta33.7
prostate39.6
salivary gland91.6
skin26.8
small intestine43.8
spleen116.7
stomach68
testis44.3
thyroid gland39
urinary bladder90
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
bronchusLow
cerebral cortexHigh
colonLow
duodenumLow
epididymisLow
gallbladderLow
kidneyLow
lungMedium
lymph nodeMedium
nasopharynxLow
oral mucosaLow
pancreasMedium
placentaLow
prostateMedium
rectumLow
small intestineLow
spleenMedium
testisLow
thyroid glandLow
tonsilLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600555, gene) Signal transducer and activator of transcription 1; STAT1OMIM
2(#613796, phenotype) Mycobacterial and viral infections, susceptibility to, autosomal recessiveOMIM
3(#614162, phenotype) Candidiasis, familial, 7; CANDF7OMIM


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