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> Protein (NX_P42679)
Protein (NX_P42679)
Protein
Gene SymbolMATK to neXtProt (NX_P42679)
DescriptionMegakaryocyte-associated tyrosine-protein kinase
Chromosome19
Location19p13.3 (3777971 ~ 3802127) to Ensembl
Sequene Features : Isoforms 3, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 8 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 76 2
2014-09-19protein level
3 55 2
2014-05-27protein level
3 55 2
2014-02-25protein level
3 55 2
2013-12-09protein level
3 42 2
2013-11-01protein level
3 40 1
2013-09-12protein level
3 40 1
2013-08-17protein level
3 40 1
2013-07-15protein level
3 27 1
2013-06-11protein level
3 27 1
2013-02-12protein level
3 15 6
2012-12-20protein level
3 16 6
2012-10-30protein level
3 16 6
2012-10-07protein level
3 16 2
2012-08-24protein level
2 8 2
2012-07-28protein level
2 8 2
2012-06-08protein level
2 11 2
2012-05-07protein level
2 11 2
2012-04-10protein level
1 10 2
2012-01-13protein level
1 7 2
2011-12-20protein level
1 7 2
2011-11-11protein level
1 7 2
2011-08-23protein level
1 7 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P42679-1
1 23 1 56432.9305
NX_P42679-2
2 23 1 56762.2341
NX_P42679-3
0 22 1 51865.6307
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-751664,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-751664,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
3 EBI-751664,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
4 EBI-751664,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood155
bone13
bone marrow41
brain52
connective tissue6
embryonic tissue9
eye153
kidney4
lung11
lymph node11
nerve64
ovary9
pancreas56
placenta7
spleen112
testis2
tonsil58
Health State
TissuesTPM*
normal28
glioma27
leukemia84
lung tumor29
lymphoma13
non-neoplasia10
ovarian tumor13
pancreatic tumor114
retinoblastoma516
Developmental Stage
TissuesTPM*
adult13
blastocyst32
neonate128
fetus35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1
appendix4
bone marrow8.5
cerebral cortex7.9
colon1.7
duodenum3.3
gallbladder2.2
liver1.4
lung4.5
lymph node5.6
prostate1.5
salivary gland1.2
small intestine3.4
spleen11.7
stomach3
testis2
urinary bladder1.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineHigh
soft tissue 1Medium
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600038, gene) Megakaryoctye-associated tyrosine kinase; MATKOMIM


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