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> Protein (NX_P42681)
Protein (NX_P42681)
Protein
Gene SymbolTXK to neXtProt (NX_P42681)
DescriptionTyrosine-protein kinase TXK
Chromosome4
Location4p12 (48068410 ~ 48136273) to Ensembl
Sequene Features : Isoforms 1, Variants 73, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of interferon-gamma-mediated signaling pathway
.T cell receptor signaling pathway
.protein autophosphorylation
  + 14 more...
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 73 2
2014-09-19protein level
1 57 2
2014-05-27protein level
1 57 2
2014-02-25protein level
1 56 2
2013-12-09protein level
1 48 2
2013-11-01protein level
1 43 2
2013-09-12protein level
1 43 2
2013-08-17protein level
1 43 2
2013-07-15protein level
1 25 2
2013-06-11protein level
1 25 2
2013-02-12protein level
1 12 2
2012-12-20protein level
1 10 2
2012-10-30protein level
1 13 2
2012-10-07protein level
1 13 2
2012-08-24protein level
1 9 2
2012-07-28protein level
1 9 2
2012-06-08protein level
1 11 2
2012-05-07protein level
1 11 2
2012-04-10protein level
1 11 2
2012-01-13protein level
1 6 2
2011-12-20protein level
1 6 2
2011-11-11protein level
1 6 2
2011-08-23protein level
1 4 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P42681-1
29 0 0 61218.5715
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7877438,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone marrow20
connective tissue13
embryonic tissue9
liver14
lung5
lymph node11
muscle9
placenta98
spleen18
stomach20
thymus25
tonsil58
Health State
TissuesTPM*
normal12
chondrosarcoma12
liver tumor20
lung tumor9
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
Developmental Stage
TissuesTPM*
adult18
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix8.6
bone marrow4.1
colon1.7
duodenum1.8
esophagus1.1
gallbladder2.9
kidney1.4
lung2.3
lymph node15.2
placenta14.8
skin1.6
small intestine2
spleen10.5
stomach1.1
testis1
urinary bladder5.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600058, gene) Protein tyrosine kinase txk; TXKOMIM


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