Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P42684)
Protein (NX_P42684)
Protein
Gene SymbolABL2 to neXtProt (NX_P42684)
DescriptionAbelson tyrosine-protein kinase 2
Chromosome1
Location1q25.2 (179068462 ~ 179198819) to Ensembl
Sequene Features : Isoforms 9, Variants 146, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
9 146 19
2014-09-19protein level
9 113 20
2014-05-27protein level
9 113 20
2014-02-25protein level
9 116 19
2013-12-09protein level
9 97 19
2013-11-01protein level
9 97 18
2013-09-12protein level
9 97 18
2013-08-17protein level
9 97 19
2013-07-15protein level
9 64 19
2013-06-11protein level
9 64 19
2013-02-12protein level
9 31 312
2012-12-20protein level
10 31 328
2012-10-30protein level
10 37 328
2012-10-07protein level
10 37 38
2012-08-24protein level
10 21 38
2012-07-28protein level
10 21 38
2012-06-08protein level
10 12 38
2012-05-07protein level
10 12 38
2012-04-10protein level
10 12 38
2012-01-13protein level
10 12 38
2011-12-20protein level
10 12 38
2011-11-11protein level
10 12 38
2011-08-23protein level
4 12 36
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P42684-1
0 48 6 128262.3038
NX_P42684-10
0 43 6 116209.3572
NX_P42684-2
0 46 6 124481.4483
NX_P42684-3
0 47 6 126604.2967
NX_P42684-4
0 42 6 114086.5088
NX_P42684-5
0 44 6 117867.3643
NX_P42684-6
0 47 6 126139.4554
NX_P42684-7
0 43 6 115744.5159
NX_P42684-8
1 18 6 60825.1707
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1102694,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-1102694,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-1102694,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
4 EBI-1102694,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
5 EBI-1102694,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
6 EBI-1102694,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
7 EBI-1102694,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
8 EBI-1102694,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
9 EBI-1102694,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
10 EBI-1102694,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
11 EBI-1102694,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
12 EBI-1102694,EBI-366017 RIN1  
  .negative regulation of synaptic plasticity
.associative learning
.memory
  + 2 more...
.GTPase activator activity .neuronal cell body
.dendrite
.plasma membrane
  + 2 more...
13 EBI-1102694,EBI-80371 ERBB4  
  .positive regulation of STAT protein import into nucleus
.positive regulation of ERK1 and ERK2 cascade
.cardiac muscle tissue regeneration
  + 33 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.ATP binding
  + 4 more...
.receptor complex
.basolateral plasma membrane
.integral component of membrane
  + 7 more...
14 EBI-1102694,EBI-375446 ABI1  
  .lamellipodium morphogenesis
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 10 more...
.protein complex binding
.protein tyrosine kinase activator activity
.cytoskeletal protein binding
.extracellular exosome
.postsynaptic membrane
.SCAR complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
blood8
bone27
bone marrow20
brain29
cervix20
connective tissue67
embryonic tissue23
esophagus49
eye76
intestine8
kidney14
larynx42
liver121
lung44
mammary gland85
mouth30
muscle112
ovary19
pancreas18
pituitary gland60
placenta7
prostate21
salivary gland148
skin71
stomach52
testis36
thymus12
thyroid21
trachea38
umbilical cord72
uterus34
vascular19
Health State
TissuesTPM*
normal42
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma72
esophageal tumor57
gastrointestinal tumor50
germ cell tumor37
glioma18
head and neck tumor52
kidney tumor14
leukemia10
liver tumor135
lung tumor77
non-neoplasia20
ovarian tumor26
pancreatic tumor38
prostate cancer19
retinoblastoma193
skin tumor39
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult41
embryoid body57
blastocyst16
neonate160
fetus50
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.3
adrenal gland3.5
appendix5.3
bone marrow2.2
cerebral cortex4.8
colon3.8
duodenum2.6
esophagus2.7
gallbladder13.9
heart muscle2
kidney3
liver2.1
lung3.5
lymph node3
ovary3.6
pancreas3
placenta4
prostate3
salivary gland2.5
skin2.3
small intestine2.3
spleen2.7
stomach2.9
testis4.9
thyroid gland3.4
urinary bladder5.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164690, gene) V-abl abelson murine leukemia viral oncogene homolog 2; ABL2OMIM
2acute myelogenous leukemiaCGP


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center