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| Protein |
|
| Gene Symbol | FRK to neXtProt (NX_P42685) |
| Description | Tyrosine-protein kinase FRK |
| Chromosome | 6 |
| Location | 6q22.1 (116252312 ~ 116381921) to Ensembl |
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|
Sequene Features : Isoforms 2, Variants 89, PTMs 3 to neXtProt Sequence Features
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|
Gene
Ontologies |
| GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
.innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
+ 6 more... |
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity |
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
+ 2 more... |
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| |
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| Proteomic Evidences |
|
| |
|
| Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
|
| 2015-01-01 | | protein level | | | | | | | 2 |
| 89 |
| 3 |
|
| 2014-09-19 | | protein level | | | | | | | 1 |
| 73 |
| 3 |
|
| 2014-05-27 | | protein level | | | | | | | 1 |
| 73 |
| 3 |
|
| 2014-02-25 | | protein level | | | | | | | 1 |
| 71 |
| 3 |
|
| 2013-12-09 | | protein level | | | | | | | 1 |
| 58 |
| 3 |
|
| 2013-11-01 | | protein level | | | | | | | 1 |
| 55 |
| 3 |
|
| 2013-09-12 | | protein level | | | | | | | 1 |
| 55 |
| 3 |
|
| 2013-08-17 | | protein level | | | | | | | 1 |
| 58 |
| 3 |
|
| 2013-07-15 | | protein level | | | | | | | 1 |
| 36 |
| 3 |
|
| 2013-06-11 | | protein level | | | | | | | 1 |
| 36 |
| 3 |
|
| 2013-02-12 | | protein level | | | | | | | 1 |
| 21 |
| 5 |
|
| 2012-12-20 | | protein level | | | | | | | 1 |
| 19 |
| 5 |
|
| 2012-10-30 | | protein level | | | | | | | 1 |
| 26 |
| 5 |
|
| 2012-10-07 | | protein level | | | | | | | 1 |
| 26 |
| 5 |
|
| 2012-08-24 | | protein level | | | | | | | 1 |
| 18 |
| 5 |
|
| 2012-07-28 | | protein level | | | | | | | 1 |
| 18 |
| 5 |
|
| 2012-06-08 | | protein level | | | | | | | 1 |
| 20 |
| 5 |
|
| 2012-05-07 | | protein level | | | | | | | 1 |
| 20 |
| 5 |
|
| 2012-04-10 | | protein level | | | | | | | 1 |
| 20 |
| 5 |
|
| 2012-01-13 | | protein level | | | | | | | 1 |
| 9 |
| 5 |
|
| 2011-12-20 | | protein level | | | | | | | 1 |
| 9 |
| 5 |
|
| 2011-11-11 | | protein level | | | | | | | 1 |
| 9 |
| 5 |
|
| 2011-08-23 | | protein level | | | | | | | 1 |
| 9 |
| 5 |
|
|
| |
|
| Protein Isoforms |
|
| |
| |
|
| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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|
| |
|
| Interacting Partners |
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| |
|
| No. |
Exp. ref. |
Symbol |
|
PE |
Pr |
Ab |
Di |
|
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
| 1 |
EBI-1383583,EBI-491274 |
RB1 |
|
| | | | |
.negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
+ 39 more... |
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
+ 7 more... |
.Rb-E2F complex
.PML body
.SWI/SNF complex
+ 4 more... |
|
| 2 |
EBI-1383583,EBI-696162 |
PTEN |
|
| | | | |
.positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
+ 91 more... |
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
+ 10 more... |
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
+ 12 more... |
|
| 3 |
EBI-1383583,EBI-752094 |
BNIP2 |
|
| | | | |
.positive regulation of muscle cell differentiation
.positive regulation of GTPase activity
.negative regulation of apoptotic process
+ 2 more... |
.identical protein binding
.calcium ion binding
.GTPase activator activity |
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.cytosol
+ 2 more... |
|
| 4 |
EBI-1383583,EBI-348469 |
SF3B4 |
|
| | | | |
.positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
+ 3 more... |
.poly(A) RNA binding
.nucleotide binding |
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm |
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|
| EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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| |
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| Body Sites | |
| Tissues | TPM* | |
|
| ascites | 50 | |
| bladder | 100 | |
| connective tissue | 6 | |
| larynx | 42 | |
| liver | 9 | |
| mammary gland | 13 | |
| mouth | 30 | |
| pancreas | 4 | |
| placenta | 3 | |
| prostate | 10 | |
| testis | 27 | |
| thymus | 12 | |
|
| Health State | |
| Tissues | TPM* | |
|
| normal | 2 | |
| breast (mammary gland) tumor | 10 | |
| gastrointestinal tumor | 16 | |
| head and neck tumor | 22 | |
| non-neoplasia | 10 | |
| prostate cancer | 19 | |
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| Developmental Stage | |
| Tissues | TPM* | |
|
| adult | 5 | |
| fetus | 1 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
| |
|
| Expression level of Protein (ref. Human Protein Atlas) |
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| RNA-Seq. | |
| Tissues | FPKM | |
|
| appendix | 1 | |
| colon | 5.3 | |
| duodenum | 7.9 | |
| esophagus | 4.1 | |
| gallbladder | 3.2 | |
| heart muscle | 1.7 | |
| kidney | 8.7 | |
| liver | 2.8 | |
| lung | 1.5 | |
| pancreas | 1.8 | |
| prostate | 2.3 | |
| salivary gland | 3 | |
| small intestine | 6.6 | |
| stomach | 5.6 | |
| testis | 6 | |
| thyroid gland | 1.1 | |
| urinary bladder | 4.2 | |
|
| Cancer | |
| Tumor | Number of patients and Staining levels | |
| breast cancer | |
| carcinoid | |
| cervical cancer | |
| colorectal cancer | |
| endometrial cancer | |
| glioma | |
| head and neck cancer | |
| liver cancer | |
| lung cancer | |
| lymphoma | |
| melanoma | |
| ovarian cancer | |
| pancreatic cancer | |
| prostate cancer | |
| renal cancer | |
| skin cancer | |
| stomach cancer | |
| testis cancer | |
| thyroid cancer | |
| urothelial cancer | |
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| RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) | |
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Moderately expressed RNAs (50> FPKM >10) | |
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Lower expressed RNAs (10> FPKM >1) | |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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| Staining level colour codes |
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Highly expressed protein | |
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Moderately expressed protein | |
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Lower expressed protein | |
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Not Detected |
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| Disease |
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|
| No. | Disease Description | Ref. |
|
| 1 | (*606573, gene) Fyn-related kinase; FRK | OMIM |
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> Protein (NX_P42685)