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Protein |
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Gene Symbol | FRK to neXtProt (NX_P42685) |
Description | Tyrosine-protein kinase FRK |
Chromosome | 6 |
Location | 6q22.1 (116252312 ~ 116381921) to Ensembl |
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Sequene Features : Isoforms 2, Variants 89, PTMs 3 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.innate immune response .regulation of cell proliferation .peptidyl-tyrosine autophosphorylation + 6 more... |
.ATP binding .receptor binding .non-membrane spanning protein tyrosine kinase activity |
.extracellular exosome .extrinsic component of cytoplasmic side of plasma membrane .cytoplasm + 2 more... |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 2 |
| 89 |
| 3 |
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2014-09-19 | | protein level | | | | | | | 1 |
| 73 |
| 3 |
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2014-05-27 | | protein level | | | | | | | 1 |
| 73 |
| 3 |
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2014-02-25 | | protein level | | | | | | | 1 |
| 71 |
| 3 |
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2013-12-09 | | protein level | | | | | | | 1 |
| 58 |
| 3 |
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2013-11-01 | | protein level | | | | | | | 1 |
| 55 |
| 3 |
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2013-09-12 | | protein level | | | | | | | 1 |
| 55 |
| 3 |
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2013-08-17 | | protein level | | | | | | | 1 |
| 58 |
| 3 |
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2013-07-15 | | protein level | | | | | | | 1 |
| 36 |
| 3 |
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2013-06-11 | | protein level | | | | | | | 1 |
| 36 |
| 3 |
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2013-02-12 | | protein level | | | | | | | 1 |
| 21 |
| 5 |
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2012-12-20 | | protein level | | | | | | | 1 |
| 19 |
| 5 |
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2012-10-30 | | protein level | | | | | | | 1 |
| 26 |
| 5 |
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2012-10-07 | | protein level | | | | | | | 1 |
| 26 |
| 5 |
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2012-08-24 | | protein level | | | | | | | 1 |
| 18 |
| 5 |
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2012-07-28 | | protein level | | | | | | | 1 |
| 18 |
| 5 |
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2012-06-08 | | protein level | | | | | | | 1 |
| 20 |
| 5 |
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2012-05-07 | | protein level | | | | | | | 1 |
| 20 |
| 5 |
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2012-04-10 | | protein level | | | | | | | 1 |
| 20 |
| 5 |
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2012-01-13 | | protein level | | | | | | | 1 |
| 9 |
| 5 |
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2011-12-20 | | protein level | | | | | | | 1 |
| 9 |
| 5 |
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2011-11-11 | | protein level | | | | | | | 1 |
| 9 |
| 5 |
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2011-08-23 | | protein level | | | | | | | 1 |
| 9 |
| 5 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-1383583,EBI-491274 |
RB1 |
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.negative regulation of G1/S transition of mitotic cell cycle .hepatocyte apoptotic process .regulation of centromere complex assembly + 39 more... |
.phosphoprotein binding .androgen receptor binding .identical protein binding + 7 more... |
.Rb-E2F complex .PML body .SWI/SNF complex + 4 more... |
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2 |
EBI-1383583,EBI-696162 |
PTEN |
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.positive regulation of apoptotic signaling pathway .negative regulation of synaptic vesicle clustering .positive regulation of excitatory postsynaptic membrane potential + 91 more... |
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity .inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity .PDZ domain binding + 10 more... |
.postsynaptic membrane .Schmidt-Lanterman incisure .dendritic spine + 12 more... |
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3 |
EBI-1383583,EBI-752094 |
BNIP2 |
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.positive regulation of muscle cell differentiation .positive regulation of GTPase activity .negative regulation of apoptotic process + 2 more... |
.identical protein binding .calcium ion binding .GTPase activator activity |
.perinuclear region of cytoplasm .intracellular membrane-bounded organelle .cytosol + 2 more... |
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4 |
EBI-1383583,EBI-348469 |
SF3B4 |
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.positive regulation of mRNA splicing, via spliceosome .gene expression .RNA splicing + 3 more... |
.poly(A) RNA binding .nucleotide binding |
.U12-type spliceosomal complex .spliceosomal complex .nucleoplasm |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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ascites | 50 | |
bladder | 100 | |
connective tissue | 6 | |
larynx | 42 | |
liver | 9 | |
mammary gland | 13 | |
mouth | 30 | |
pancreas | 4 | |
placenta | 3 | |
prostate | 10 | |
testis | 27 | |
thymus | 12 | |
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Health State | |
Tissues | TPM* | |
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normal | 2 | |
breast (mammary gland) tumor | 10 | |
gastrointestinal tumor | 16 | |
head and neck tumor | 22 | |
non-neoplasia | 10 | |
prostate cancer | 19 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 5 | |
fetus | 1 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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appendix | 1 | |
colon | 5.3 | |
duodenum | 7.9 | |
esophagus | 4.1 | |
gallbladder | 3.2 | |
heart muscle | 1.7 | |
kidney | 8.7 | |
liver | 2.8 | |
lung | 1.5 | |
pancreas | 1.8 | |
prostate | 2.3 | |
salivary gland | 3 | |
small intestine | 6.6 | |
stomach | 5.6 | |
testis | 6 | |
thyroid gland | 1.1 | |
urinary bladder | 4.2 | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*606573, gene) Fyn-related kinase; FRK | OMIM |
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