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> Protein (NX_P42765)
Protein (NX_P42765)
Protein
Gene SymbolACAA2 to neXtProt (NX_P42765)
Description3-ketoacyl-CoA thiolase, mitochondrial
Chromosome18
Location18q21.1 (47309869 ~ 47340330) to Ensembl
Sequene Features : Isoforms 1, Variants 50, PTMs 31 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of mitochondrial membrane permeability involved in apoptotic process
.negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
.cellular response to hypoxia
  + 2 more...
.poly(A) RNA binding
.acetyl-CoA C-acyltransferase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 50 31
2014-09-19protein level
1 39 31
2014-05-27protein level
1 39 31
2014-02-25protein level
1 38 17
2013-12-09protein level
1 27 17
2013-11-01protein level
1 25 17
2013-09-12protein level
1 25 5
2013-08-17protein level
1 25 5
2013-07-15protein level
1 13 5
2013-06-11protein level
1 13 5
2013-02-12protein level
1 7 8
2012-12-20protein level
1 7 8
2012-10-30protein level
1 10 8
2012-10-07protein level
1 10 8
2012-08-24protein level
1 9 8
2012-07-28protein level
1 9 8
2012-06-08protein level
1 11 8
2012-05-07protein level
1 11 8
2012-04-10protein level
1 11 8
2012-01-13protein level
1 7 8
2011-12-20protein level
1 7 8
2011-11-11protein level
1 7 8
2011-08-23protein level
1 7 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P42765-1
19 0 0 41897.525
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites100
bladder33
blood81
bone marrow102
brain67
cervix82
connective tissue53
embryonic tissue117
eye95
heart223
intestine193
kidney374
larynx127
liver160
lung173
lymph699
lymph node33
mammary gland171
mouth30
muscle188
nerve64
ovary98
pancreas46
parathyroid48
pharynx73
placenta67
prostate52
salivary gland98
skin113
spleen18
stomach177
testis62
thymus62
thyroid193
trachea19
umbilical cord145
uterus73
vascular116
Health State
TissuesTPM*
normal107
breast (mammary gland) tumor75
cervical tumor57
chondrosarcoma36
colorectal tumor62
gastrointestinal tumor177
germ cell tumor98
glioma102
head and neck tumor67
kidney tumor72
leukemia116
liver tumor156
lung tumor321
lymphoma429
non-neoplasia103
ovarian tumor91
pancreatic tumor76
primitive neuroectodermal tumor of the CNS149
prostate cancer38
retinoblastoma107
skin tumor79
soft tissue/muscle tissue tumor119
uterine tumor55
Developmental Stage
TissuesTPM*
adult95
embryoid body100
blastocyst97
neonate64
fetus61
infant170
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue74.1
adrenal gland46.5
appendix35.6
bone marrow15.3
cerebral cortex15.2
colon104.6
duodenum102.1
esophagus21.4
gallbladder36.1
heart muscle62.5
kidney188.1
liver296.4
lung32.5
lymph node25.9
ovary25.1
pancreas17.1
placenta19.1
prostate17.1
salivary gland9
skin5.8
small intestine104.9
spleen17.2
stomach24.8
testis29.2
thyroid gland41.3
urinary bladder26.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastMedium
bronchusLow
cerebral cortexMedium
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisLow
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverHigh
lungMedium
nasopharynxLow
pancreasMedium
parathyroid glandMedium
placentaLow
rectumHigh
salivary glandMedium
seminal vesicleMedium
skin 1Medium
small intestineHigh
soft tissue 1Medium
soft tissue 2Low
stomach 1Low
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604770, gene) Acetyl-coa acyltransferase 2; ACAA2OMIM


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