Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P42768)
Protein (NX_P42768)
Protein
Gene SymbolWAS to neXtProt (NX_P42768)
DescriptionWiskott-Aldrich syndrome protein
ChromosomeX
LocationXp11.23 (48534985 ~ 48549818) to Ensembl
Sequene Features : Isoforms 1, Variants 79, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 79 8
2014-09-19protein level
1 66 8
2014-05-27protein level
1 66 8
2014-02-25protein level
1 66 8
2013-12-09protein level
1 61 8
2013-11-01protein level
1 61 8
2013-09-12protein level
1 61 8
2013-08-17protein level
1 61 8
2013-07-15protein level
1 51 5
2013-06-11protein level
1 51 5
2013-02-12protein level
1 36 3
2012-12-20protein level
1 36 3
2012-10-30protein level
1 36 3
2012-10-07protein level
1 36 3
2012-08-24protein level
1 35 3
2012-07-28protein level
1 35 3
2012-06-08protein level
1 34 3
2012-05-07protein level
1 34 3
2012-04-10protein level
1 34 3
2012-01-13protein level
1 33 3
2011-12-20protein level
1 33 3
2011-11-11protein level
1 33 3
2011-08-23protein level
1 33 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P42768-1
21 0 0 52879.7111
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346375,EBI-346356 WIPF1  
  .response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
2 EBI-346375,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
3 EBI-346375,EBI-311323 SORBS2  
  .cell migration
.cell adhesion
.actin filament organization
.metal ion binding
.poly(A) RNA binding
.structural constituent of muscle
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.actin cytoskeleton
  + 2 more...
4 EBI-346375,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
5 EBI-346375,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
6 EBI-346375,EBI-624835 BTK  
  .apoptotic signaling pathway
.cellular response to molecule of fungal origin
.positive regulation of NF-kappaB transcription factor activity
  + 28 more...
.metal ion binding
.identical protein binding
.phosphatidylinositol-3,4,5-trisphosphate binding
  + 3 more...
.perinuclear region of cytoplasm
.membrane raft
.intracellular membrane-bounded organelle
  + 7 more...
7 EBI-346375,EBI-351886 CTTN  
  .negative regulation of extrinsic apoptotic signaling pathway
.lamellipodium organization
.dendritic spine maintenance
  + 12 more...
.profilin binding .mitotic spindle midzone
.extracellular exosome
.dendritic spine
  + 10 more...
8 EBI-346375,EBI-2481535 SNX33  
  .positive regulation of protein localization to cell surface
.negative regulation of protein localization to cell surface
.membrane tubulation
  + 12 more...
.identical protein binding
.phosphatidylinositol binding
.cytoplasmic vesicle membrane
.extrinsic component of membrane
.cytoplasmic membrane-bounded vesicle
  + 3 more...
9 EBI-346375,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
10 EBI-346375,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood212
bone69
bone marrow61
brain3
connective tissue6
heart22
intestine17
kidney4
liver4
lung2
lymph338
lymph node122
nerve64
ovary19
placenta10
prostate5
spleen93
stomach31
thymus25
thyroid64
tonsil235
uterus4
Health State
TissuesTPM*
normal18
chondrosarcoma48
gastrointestinal tumor8
germ cell tumor34
glioma9
head and neck tumor14
leukemia179
lymphoma221
ovarian tumor26
prostate cancer9
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult21
fetus8
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14
adrenal gland6.4
appendix78.1
bone marrow58.2
cerebral cortex4.9
colon8.1
duodenum8
esophagus6.2
gallbladder16.7
heart muscle3.5
kidney3.2
liver5.2
lung17.7
lymph node77.5
ovary2.6
pancreas1.8
placenta13.5
prostate2.9
salivary gland5.2
skin2.8
small intestine13.9
spleen71.5
stomach10.8
testis3.1
thyroid gland2.2
urinary bladder20.9
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowHigh
breastLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonLow
fallopian tubeLow
gallbladderLow
hippocampusLow
lateral ventricleLow
lungMedium
lymph nodeHigh
pancreasLow
parathyroid glandLow
placentaLow
rectumLow
skeletal muscleMedium
skin 1High
soft tissue 1Medium
spleenHigh
stomach 2Low
testisLow
thyroid glandLow
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#300299, phenotype) Neutropenia, severe congenital, x-linked; SCNXOMIM
2(*300392, gene) Was gene; WASOMIM
3(#301000, phenotype) Wiskott-aldrich syndrome; WASOMIM
4(#313900, phenotype) Thrombocytopenia 1; THC1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center