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> Protein (NX_P42773)
Protein (NX_P42773)
Protein
Gene SymbolCDKN2C to neXtProt (NX_P42773)
DescriptionCyclin-dependent kinase 4 inhibitor C
Chromosome1
Location1p32.3 (51426417 ~ 51440305) to Ensembl
Sequene Features : Isoforms 1, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein serine/threonine kinase activity
.oligodendrocyte differentiation
.negative regulation of phosphorylation
  + 6 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 29 0
2014-09-19protein level
1 23 0
2014-05-27protein level
1 23 0
2014-02-25protein level
1 23 0
2013-12-09protein level
1 18 0
2013-11-01protein level
1 18 0
2013-09-12protein level
1 18 0
2013-08-17protein level
1 18 0
2013-07-15protein level
1 9 0
2013-06-11protein level
1 9 0
2013-02-12protein level
1 7 0
2012-12-20protein level
1 7 0
2012-10-30protein level
1 9 0
2012-10-07protein level
1 9 0
2012-08-24protein level
1 9 0
2012-07-28protein level
1 9 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 3 0
2011-12-20protein level
1 3 0
2011-11-11protein level
1 3 0
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P42773-1
8 0 0 18116.24
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-711290,EBI-2371423 AHCYL1  
  .response to calcium ion
.regulation of anion transport
.S-adenosylmethionine cycle
  + 6 more...
.hydrolase activity .extracellular exosome
.cytosol
.endoplasmic reticulum
2 EBI-711290,EBI-295644 CDK4  
  .negative regulation of cell cycle arrest
.response to hyperoxia
.cell division
  + 20 more...
.cyclin binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.nuclear membrane
.tight junction
  + 7 more...
3 EBI-711290,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
4 EBI-711290,EBI-295663 CDK6  
  .negative regulation of cellular senescence
.regulation of cell motility
.hematopoietic stem cell differentiation
  + 26 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.cytosol
.centrosome
.cytoplasm
  + 4 more...
5 EBI-711290,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
6 EBI-711290,EBI-722877 TCF12  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
7 EBI-711290,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
8 EBI-711290,EBI-372578 NAGK  
  .carbohydrate phosphorylation
.N-acetylneuraminate catabolic process
.N-acetylmannosamine metabolic process
.N-acetylglucosamine metabolic process
.N-acetylglucosamine kinase activity
.N-acylmannosamine kinase activity
.ATP binding
.extracellular exosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
ascites150
blood114
bone55
bone marrow205
brain57
cervix164
connective tissue87
embryonic tissue14
esophagus49
eye52
heart44
intestine30
kidney37
liver19
lung23
lymph180
lymph node11
mammary gland6
mouth45
muscle37
nerve64
ovary9
pancreas28
placenta14
prostate21
salivary gland246
skin33
spleen37
stomach62
testis11
thymus276
trachea38
uterus60
vascular96
Health State
TissuesTPM*
normal27
adrenal tumor237
cervical tumor115
chondrosarcoma72
colorectal tumor8
esophageal tumor57
gastrointestinal tumor109
germ cell tumor15
glioma139
head and neck tumor52
kidney tumor101
leukemia158
liver tumor41
lung tumor48
lymphoma138
non-neoplasia82
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS370
prostate cancer9
retinoblastoma129
skin tumor23
soft tissue/muscle tissue tumor79
uterine tumor33
Developmental Stage
TissuesTPM*
adult28
neonate32
fetus30
infant510
juvenile305
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue59.7
adrenal gland17.7
appendix7.2
bone marrow16.6
cerebral cortex6.4
colon10.3
duodenum9.8
esophagus7.9
gallbladder13
heart muscle13.9
kidney6.7
liver3.2
lung7
lymph node15.7
ovary33.2
pancreas6.3
placenta5.2
prostate6.7
salivary gland5
skin11.8
small intestine9.8
spleen7.7
stomach4.8
testis4.4
thyroid gland6.9
urinary bladder12.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603369, gene) Cyclin-dependent kinase inhibitor 2c; CDKN2COMIM
2glioma;multiple myelomaCGP


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