Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P42858)
Protein (NX_P42858)
Protein
Gene SymbolHTT to neXtProt (NX_P42858)
DescriptionHuntingtin
Chromosome4
Location4p16.3 (3076408 ~ 3245676) to Ensembl
Sequene Features : Isoforms 1, Variants 285, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 285 16
2014-09-19protein level
1 215 16
2014-05-27protein level
1 215 16
2014-02-25protein level
1 212 16
2013-12-09protein level
1 160 16
2013-11-01protein level
1 155 12
2013-09-12protein level
1 155 13
2013-08-17protein level
1 155 13
2013-07-15protein level
1 106 13
2013-06-11protein level
1 106 13
2013-02-12protein level
1 41 12
2012-12-20protein level
1 40 12
2012-10-30protein level
1 54 12
2012-10-07protein level
1 54 12
2012-08-24protein level
1 53 12
2012-07-28protein level
1 52 12
2012-06-08protein level
1 54 12
2012-05-07protein level
1 40 12
2012-04-10protein level
1 40 12
2012-01-13protein level
1 44 12
2011-12-20protein level
1 44 12
2011-11-11protein level
1 44 12
2011-08-23protein level
1 44 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P42858-1
141 0 0 347381.7887
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-466029,EBI-473886 HIP1  
  .apoptotic signaling pathway
.clathrin-mediated endocytosis
.clathrin coat assembly
  + 7 more...
.phosphatidylinositol binding
.clathrin binding
.structural constituent of cytoskeleton
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
.clathrin-coated vesicle
  + 5 more...
2 EBI-466029,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
3 EBI-466029,EBI-744871 NME4  
  .nucleobase-containing small molecule metabolic process
.small molecule metabolic process
.regulation of apoptotic process
  + 9 more...
.metal ion binding
.lipid binding
.ATP binding
.nucleoside diphosphate kinase activity
.cytosol
.mitochondrial matrix
.mitochondrial intermembrane space
  + 2 more...
4 EBI-466029,EBI-1396921 TRAFD1  
  .negative regulation of innate immune response
.response to cytokine
.metal ion binding .N/A
5 EBI-466029,EBI-395638 DNALI1  
  .metabolic process
.single fertilization
.movement of cell or subcellular component
.microtubule motor activity .filopodium
.axoneme
.axonemal dynein complex
.cytoplasm
6 EBI-466029,EBI-473271 TCERG1  
  .transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.poly(A) RNA binding
.transcription coactivator activity
.RNA polymerase II transcription corepressor activity
.RNA polymerase II repressing transcription factor binding
.actin cytoskeleton
.nucleolus
.nucleus
7 EBI-466029,EBI-368166 SRGAP3  
  .regulation of small GTPase mediated signal transduction
.negative regulation of cell migration
.small GTPase mediated signal transduction
.Rac GTPase binding
.GTPase activator activity
.cytosol
.cytoplasm
8 EBI-466029,EBI-473954 MTSS1  
  .epithelial cell proliferation involved in renal tubule morphogenesis
.nephron tubule epithelial cell differentiation
.glomerulus morphogenesis
  + 16 more...
.identical protein binding
.receptor binding
.actin monomer binding
.endocytic vesicle
.actin cytoskeleton
.adherens junction
  + 2 more...
9 EBI-466029,EBI-1051034 SRGAP2  
  .negative regulation of neuron migration
.dendritic spine development
.regulation of small GTPase mediated signal transduction
  + 9 more...
.Rac GTPase binding
.protein homodimerization activity
.GTPase activator activity
.phagocytic vesicle
.postsynaptic membrane
.dendritic spine head
  + 7 more...
10 EBI-466029,EBI-744408 RNF40  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.histone H2B ubiquitination
  + 2 more...
.protein homodimerization activity
.ubiquitin protein ligase binding
.ligase activity
  + 3 more...
.neuron projection
.HULC complex
.membrane
  + 3 more...
11 EBI-466029,EBI-347233 NCOR1  
  .regulation of fatty acid transport
.regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
.regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
  + 22 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.histone deacetylase binding
  + 6 more...
.transcriptional repressor complex
.membrane
.spindle microtubule
  + 5 more...
12 EBI-466029,EBI-473291 PRPF40A  
  .cell division
.regulation of cytokinesis
.cell migration
  + 5 more...
.poly(A) RNA binding .nuclear speck
.nuclear matrix
.membrane
  + 2 more...
13 EBI-466029,EBI-624237 TACC1  
  .cell division
.regulation of microtubule-based process
.interkinetic nuclear migration
  + 5 more...
.N/A .intermediate filament cytoskeleton
.microtubule cytoskeleton
.microtubule organizing center
  + 2 more...
14 EBI-466029,EBI-7251981 WBP4  
  .mRNA cis splicing, via spliceosome .proline-rich region binding
.zinc ion binding
.nucleic acid binding
.nuclear speck
.plasma membrane
.spliceosomal complex
.nucleoplasm
15 EBI-466029,EBI-347559 IKBKAP  
  .regulation of protein kinase activity
.positive regulation of cell migration
.signal transduction
  + 6 more...
.phosphorylase kinase regulator activity
.signal transducer activity
.Elongator holoenzyme complex
.transcription elongation factor complex
.cytoplasm
  + 2 more...
16 EBI-466029,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
17 EBI-466029,EBI-713279 FTL  
  .membrane organization
.transmembrane transport
.iron ion homeostasis
  + 4 more...
.identical protein binding
.ferric iron binding
.iron ion binding
.extracellular exosome
.membrane
.intracellular ferritin complex
.cytosol
18 EBI-466029,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
19 EBI-466029,EBI-353208 XRCC6  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
20 EBI-466029,EBI-1237386 P4HA1  
  .collagen fibril organization
.peptidyl-proline hydroxylation to 4-hydroxy-L-proline
.L-ascorbic acid binding
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
.iron ion binding
.procollagen-proline 4-dioxygenase activity
.intracellular membrane-bounded organelle
.procollagen-proline 4-dioxygenase complex
.membrane
  + 3 more...
21 EBI-466029,EBI-353408 PKM  
  .canonical glycolysis
.small molecule metabolic process
.programmed cell death
  + 2 more...
.poly(A) RNA binding
.potassium ion binding
.MHC class II protein complex binding
  + 3 more...
.extracellular exosome
.vesicle
.extracellular matrix
  + 6 more...
22 EBI-466029,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
23 EBI-466029,EBI-473138 PFN2  
  .regulation of synaptic vesicle exocytosis
.positive regulation of protein stabilization
.negative regulation of ruffle assembly
  + 8 more...
.phosphatidylinositol-4,5-bisphosphate binding
.actin monomer binding
.adenyl-nucleotide exchange factor activity
.extracellular exosome
.terminal bouton
.cytoskeleton
.cytoplasm
24 EBI-466029,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
25 EBI-466029,EBI-348313 RPL4  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.ribonucleoprotein complex
.cytosolic large ribosomal subunit
  + 6 more...
26 EBI-466029,EBI-781384 PPARG  
  .negative regulation of pancreatic stellate cell proliferation
.response to metformin
.cellular response to hyperoxia
  + 64 more...
.alpha-actinin binding
.arachidonic acid binding
.retinoid X receptor binding
  + 15 more...
.RNA polymerase II transcription factor complex
.perinuclear region of cytoplasm
.cytosol
  + 2 more...
27 EBI-466029,EBI-985879 SNCA  
  .regulation of reactive oxygen species biosynthetic process
.regulation of synaptic vesicle recycling
.positive regulation of hydrogen peroxide catabolic process
  + 63 more...
.phosphoprotein binding
.tau protein binding
.dynein binding
  + 14 more...
.perinuclear region of cytoplasm
.fibril
.terminal bouton
  + 21 more...
28 EBI-466029,EBI-396513 MRE11A  
  .nucleic acid phosphodiester bond hydrolysis
.innate immune response
.positive regulation of kinase activity
  + 22 more...
.manganese ion binding
.3'-5' exonuclease activity
.protein C-terminus binding
  + 5 more...
.site of double-strand break
.Mre11 complex
.cytosol
  + 3 more...
29 EBI-466029,EBI-359063 COPB1  
  .membrane organization
.COPI coating of Golgi vesicle
.viral process
  + 3 more...
.structural molecule activity .intracellular membrane-bounded organelle
.COPI vesicle coat
.membrane
  + 7 more...
30 EBI-466029,EBI-9392340 HAP1  
  .positive regulation of nonmotile primary cilium assembly
.regulation of organelle transport along microtubule
.negative regulation of beta-amyloid formation
  + 19 more...
.brain-derived neurotrophic factor binding
.ion channel binding
.axon
.cell junction
.inclusion body
  + 8 more...
31 EBI-466029,EBI-473850 UBE2K  
  .protein K48-linked ubiquitination
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase activity
.ubiquitin-ubiquitin ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.intermediate filament cytoskeleton
.actin cytoskeleton
  + 2 more...
32 EBI-466029,EBI-79722 HIST1H3A  
  .regulation of gene silencing
.protein heterotetramerization
.negative regulation of gene expression, epigenetic
  + 10 more...
.histone binding
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 6 more...
33 EBI-466029,EBI-713135 DNM1  
  .clathrin-mediated endocytosis
.ephrin receptor signaling pathway
.receptor internalization
  + 4 more...
.poly(A) RNA binding
.identical protein binding
.protein kinase binding
  + 2 more...
.extracellular exosome
.membrane coat
.plasma membrane
.microtubule
34 EBI-466029,EBI-523590 CHD3  
  .centrosome organization
.DNA duplex unwinding
.chromatin modification
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.ATP binding
  + 3 more...
.intermediate filament cytoskeleton
.NuRD complex
.centrosome
  + 4 more...
35 EBI-466029,EBI-711968 ECH1  
  .fatty acid beta-oxidation .isomerase activity
.receptor binding
.extracellular exosome
.membrane
.peroxisome
.mitochondrion
36 EBI-466029,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
37 EBI-466029,EBI-715074 DCTN2  
  .melanosome transport
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.cell proliferation
  + 5 more...
.spectrin binding
.motor activity
.extracellular exosome
.vesicle
.growth cone
  + 8 more...
38 EBI-466029,EBI-473101 CRMP1  
  .axon guidance
.nervous system development
.nucleobase-containing compound metabolic process
.microtubule cytoskeleton organization
.hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds .neuronal cell body
.dendrite
.cytosol
  + 3 more...
39 EBI-466029,EBI-356015 DYNC1H1  
  .establishment of spindle localization
.stress granule assembly
.cytoplasmic mRNA processing body assembly
  + 7 more...
.poly(A) RNA binding
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.filopodium
.membrane
  + 4 more...
40 EBI-466029,EBI-742698 NBR1  
  .protein oligomerization
.negative regulation of osteoblast differentiation
.regulation of stress-activated MAPK cascade
  + 2 more...
.mitogen-activated protein kinase binding
.ubiquitin binding
.zinc ion binding
.extracellular exosome
.M band
.cytoplasmic vesicle
  + 6 more...
41 EBI-466029,EBI-1042535 ERCC6L  
  .cell division
.small GTPase mediated signal transduction
.mitotic nuclear division
.mitotic cell cycle
.ATP binding
.helicase activity
.DNA binding
.membrane
.plasma membrane
.cytosol
  + 4 more...
42 EBI-466029,EBI-2654581 DNAJC21  
  .protein folding .poly(A) RNA binding
.zinc ion binding
.ribosome
43 EBI-466029,EBI-2372238 RNF20  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.positive regulation of transcription, DNA-templated
  + 7 more...
.histone binding
.ubiquitin protein ligase binding
.ligase activity
  + 6 more...
.HULC complex
.nucleolus
.nucleoplasm
  + 2 more...
44 EBI-466029,EBI-2481729 SRGAP1  
  .regulation of small GTPase mediated signal transduction
.negative regulation of cell migration
.cell migration
  + 3 more...
.Rac GTPase binding
.GTPase activator activity
.cytosol
.cytoplasm
45 EBI-466029,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
46 EBI-466029,EBI-1569256 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
47 EBI-466029,EBI-988764 ARHGAP24  
  .negative regulation of ruffle assembly
.regulation of small GTPase mediated signal transduction
.wound healing, spreading of epidermal cells
  + 4 more...
.GTPase activator activity .cell projection
.focal adhesion
.cytoskeleton
.cytosol
48 EBI-466029,EBI-473160 PIAS4  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.positive regulation of keratinocyte apoptotic process
.negative regulation of transcription, DNA-templated
  + 8 more...
.SUMO ligase activity
.ubiquitin protein ligase binding
.SUMO transferase activity
  + 3 more...
.PML body
.nuclear matrix
.cytoplasm
  + 2 more...
49 EBI-466029,EBI-310600 FNBP4  
  .N/A .N/A .nucleoplasm
50 EBI-466029,EBI-6447163 MAGEB6  
  .N/A .N/A .N/A
51 EBI-466029,EBI-6448284 XAGE3  
  .N/A .N/A .N/A
52 EBI-466029,EBI-2558770 PIBF1  
  .N/A .N/A .centrosome
53 EBI-466029,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
54 EBI-466029,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
55 EBI-466029,EBI-356349 TANK  
  .innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
56 EBI-466029,EBI-1051152 OSTF1  
  .signal transduction
.ossification
.N/A .extracellular exosome
.cytoplasm
.intracellular
57 EBI-466029,EBI-302524 USP9X  
  .regulation of proteasomal protein catabolic process
.cell division
.axon extension
  + 16 more...
.co-SMAD binding
.cysteine-type peptidase activity
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.apical part of cell
.growth cone
.membrane
  + 2 more...
58 EBI-466029,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
59 EBI-466029,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
60 EBI-466029,EBI-6448240 ZFYVE19  
  .cell division
.negative regulation of cytokinesis
.abscission
.cell cycle
.phosphatidylinositol-3-phosphate binding
.zinc ion binding
.cleavage furrow
.midbody
.centrosome
.cytoplasm
61 EBI-466029,EBI-2680803 JAKMIP1  
  .cognition
.protein transport
.GABA receptor binding
.RNA binding
.ribonucleoprotein complex
.extrinsic component of membrane
.microtubule
.cytoplasm
62 EBI-466029,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
63 EBI-466029,EBI-394506 MED15  
  .stem cell maintenance
.gene expression
.transcription initiation from RNA polymerase II promoter
.RNA polymerase II transcription cofactor activity .mediator complex
.membrane
.cytoplasm
  + 2 more...
64 EBI-466029,EBI-396435 FEZ1  
  .cellular response to growth factor stimulus
.establishment of mitochondrion localization
.positive regulation of neuron projection development
  + 4 more...
.N/A .dendrite
.axon
.microtubule cytoskeleton
  + 5 more...
65 EBI-466029,EBI-473910 SH3GL3  
  .central nervous system development
.signal transduction
.endocytosis
.identical protein binding
.lipid binding
.extracellular exosome
.early endosome membrane
66 EBI-466029,EBI-749370 UBAC1  
  .protein ubiquitination .N/A .extracellular exosome
.plasma membrane
.Golgi apparatus
.cytoplasm
67 EBI-466029,EBI-749118 WAC  
  .histone H2B conserved C-terminal lysine ubiquitination
.positive regulation of transcription, DNA-templated
.G1 DNA damage checkpoint
  + 5 more...
.chromatin binding
.RNA polymerase II core binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
.nucleus
68 EBI-466029,EBI-2811583 NUPL1  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.nuclear pore
.nuclear envelope
69 EBI-466029,EBI-433642 SORBS1  
  .positive regulation of establishment of protein localization to plasma membrane
.focal adhesion assembly
.positive regulation of lipid biosynthetic process
  + 9 more...
.cytoskeletal protein binding
.insulin receptor binding
.SH3/SH2 adaptor activity
.actin binding
.membrane raft
.nuclear matrix
.focal adhesion
  + 10 more...
70 EBI-466029,EBI-712721 SRRT  
  .neuronal stem cell maintenance
.response to arsenic-containing substance
.primary miRNA processing
  + 3 more...
.poly(A) RNA binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
71 EBI-466029,EBI-721769 PACSIN1  
  .positive regulation of dendrite development
.membrane tubulation
.establishment of protein localization to plasma membrane
  + 7 more...
.cytoskeletal protein binding
.phospholipid binding
.perinuclear region of cytoplasm
.synapse
.axon terminus
  + 11 more...
72 EBI-466029,EBI-945869 SETD2  
  .histone H3-K36 trimethylation
.coronary vasculature morphogenesis
.embryonic placenta morphogenesis
  + 15 more...
.histone-lysine N-methyltransferase activity .chromosome
.nucleoplasm
73 EBI-466029,EBI-2341005 MKRN2  
  .protein ubiquitination .poly(A) RNA binding
.ligase activity
.zinc ion binding
.intracellular
74 EBI-466029,EBI-4403434 GOLPH3L  
  .positive regulation of protein secretion
.Golgi organization
.phosphatidylinositol-4-phosphate binding .trans-Golgi network membrane
.Golgi cisterna membrane
.Golgi membrane
75 EBI-466029,EBI-4397791 DNAJC4  
  .response to unfolded protein
.protein folding
.unfolded protein binding .integral component of membrane
.membrane
.mitochondrion
76 EBI-466029,EBI-740641 HMG20A  
  .negative regulation of neuron differentiation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.nucleus
77 EBI-466029,EBI-927511 BAZ1A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin remodeling
.DNA-dependent DNA replication
.zinc ion binding .ACF complex
.CHRAC
.nuclear chromosome
78 EBI-466029,EBI-1055336 DNAJC11  
  .N/A .N/A .extracellular exosome
.mitochondrial inner membrane
79 EBI-466029,EBI-473176 KIAA1377  
  .cilium assembly
.cytoplasmic microtubule organization
.mitotic spindle organization
.N/A .ciliary base
.midbody
.centrosome
.cytoplasm
80 EBI-466029,EBI-750630 HEY2  
  .regulation of vasculogenesis
.negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
.negative regulation of cardiac vascular smooth muscle cell differentiation
  + 47 more...
.sequence-specific DNA binding
.histone deacetylase binding
.microsatellite binding
  + 5 more...
.transcriptional repressor complex
.cytoplasm
.nucleoplasm
.nucleus
81 EBI-466029,EBI-6448852 EVL  
  .negative regulation of ruffle assembly
.positive regulation of stress fiber assembly
.protein homotetramerization
  + 9 more...
.SH3 domain binding
.profilin binding
.lamellipodium
.membrane
.focal adhesion
  + 3 more...
82 EBI-466029,EBI-867196 MBD1  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.methyl-CpG binding
.zinc ion binding
.transcription corepressor activity
  + 2 more...
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
83 EBI-466029,EBI-466061 GIT1  
  .ephrin receptor signaling pathway
.regulation of cytokinesis
.regulation of G-protein coupled receptor protein signaling pathway
.axon guidance
.zinc ion binding
.GTPase activator activity
.aggresome
.membrane
.focal adhesion
  + 2 more...
84 EBI-466029,EBI-394707 MED31  
  .limb development
.negative regulation of fibroblast proliferation
.gene expression
  + 2 more...
.RNA polymerase II transcription cofactor activity .mediator complex
.nucleoplasm
85 EBI-466029,EBI-1054873 GTF3C3  
  .tRNA transcription from RNA polymerase III promoter
.5S class rRNA transcription from RNA polymerase III type 1 promoter
.gene expression
  + 2 more...
.DNA binding .nucleoplasm
.transcription factor TFIIIC complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder100
blood32
bone125
bone marrow20
brain68
cervix61
connective tissue26
embryonic tissue65
eye95
intestine38
kidney37
larynx383
liver9
lung137
lymph22
lymph node144
mammary gland52
mouth60
muscle47
ovary98
pancreas32
parathyroid194
placenta28
prostate73
salivary gland148
skin28
spleen37
stomach31
testis59
thymus25
thyroid85
trachea19
uterus60
vascular38
Health State
TissuesTPM*
normal56
bladder carcinoma170
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma144
colorectal tumor62
gastrointestinal tumor42
germ cell tumor87
glioma55
head and neck tumor127
kidney tumor72
leukemia10
liver tumor20
lung tumor87
lymphoma13
ovarian tumor105
pancreatic tumor66
primitive neuroectodermal tumor of the CNS31
prostate cancer125
retinoblastoma129
skin tumor47
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult77
embryoid body114
blastocyst32
fetus48
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.8
adrenal gland9.5
appendix13.5
bone marrow15.7
cerebral cortex15
colon13.6
duodenum8.6
esophagus14
gallbladder14.1
heart muscle5.7
kidney13.8
liver6
lung14.4
lymph node17.9
ovary9.8
pancreas13.8
placenta9.6
prostate9.7
salivary gland6.9
skin20.3
small intestine12.1
spleen14.5
stomach9.8
testis16.7
thyroid gland18.2
urinary bladder11.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeHigh
gallbladderLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungLow
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleHigh
skin 1Low
skin 2Low
small intestineMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#143100, phenotype) Huntington disease; HDOMIM
2(*613004, gene) Huntingtin; HTTOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center