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> Protein (NX_P43005)
Protein (NX_P43005)
Protein
Gene SymbolSLC1A1 to neXtProt (NX_P43005)
DescriptionExcitatory amino acid transporter 3
Chromosome9
Location9p24.2 (4490444 ~ 4587469) to Ensembl
Sequene Features : Isoforms 1, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cysteine transmembrane transport
.L-glutamate transmembrane transport
.D-aspartate import
  + 8 more...
.cysteine transmembrane transporter activity
.sodium:dicarboxylate symporter activity
.glutamate binding
  + 2 more...
.extracellular exosome
.apical plasma membrane
.membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 64 3
2014-09-19protein level
1 46 3
2014-05-27protein level
1 46 3
2014-02-25protein level
1 46 3
2013-12-09protein level
1 36 3
2013-11-01protein level
1 35 3
2013-09-12protein level
1 35 3
2013-08-17protein level
1 35 3
2013-07-15protein level
1 21 3
2013-06-11protein level
1 21 3
2013-02-12protein level
1 12 3
2012-12-20protein level
1 12 3
2012-10-30protein level
1 14 3
2012-10-07protein level
1 14 3
2012-08-24protein level
1 13 3
2012-07-28protein level
1 13 3
2012-06-08protein level
1 22 3
2012-05-07protein level
1 19 3
2012-04-10protein level
1 19 3
2012-01-13protein level
1 15 3
2011-12-20protein level
1 15 3
2011-11-11protein level
1 15 3
2011-08-23protein level
1 15 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43005-1
20 0 0 57063.0999
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745376,EBI-10173166 LDLRAD1  
  .N/A .N/A .integral component of membrane
2 EBI-745376,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bone27
brain23
cervix41
connective tissue20
embryonic tissue14
eye33
intestine21
kidney94
liver29
lung8
lymph node100
muscle18
pancreas14
placenta7
testis9
trachea38
uterus8
vascular19
Health State
TissuesTPM*
normal24
adrenal tumor79
bladder carcinoma56
cervical tumor57
chondrosarcoma48
colorectal tumor26
germ cell tumor22
glioma18
leukemia10
liver tumor10
non-neoplasia10
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult19
embryoid body14
blastocyst16
fetus19
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.7
adrenal gland1.8
appendix2.4
cerebral cortex17.2
colon11.4
duodenum30.3
esophagus2.4
gallbladder27.1
kidney42.6
liver14.9
lung22.6
lymph node2.3
placenta5.6
prostate6.3
salivary gland3.3
small intestine59.3
stomach2.6
thyroid gland30.5
urinary bladder4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*133550, gene) Solute carrier family 1 (neuronal/epithelial high affinity glutamateOMIM
2(-222730, phenotype) Dicarboxylicamino aciduriaOMIM


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