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> Protein (NX_P43146)
Protein (NX_P43146)
Protein
Gene SymbolDCC to neXtProt (NX_P43146)
DescriptionNetrin receptor DCC
Chromosome18
Location18q21.2 (49866542 ~ 51057784) to Ensembl
Sequene Features : Isoforms 1, Variants 429, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of dendrite development
.regulation of neuron death
.extrinsic apoptotic signaling pathway in absence of ligand
  + 14 more...
.netrin receptor activity
.transmembrane signaling receptor activity
.transcription coactivator activity
.membrane raft
.growth cone membrane
.axon
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 429 15
2014-09-19protein level
1 296 15
2014-05-27protein level
1 296 15
2014-02-25protein level
1 289 15
2013-12-09protein level
1 252 15
2013-11-01protein level
1 219 15
2013-09-12protein level
1 219 15
2013-08-17protein level
1 219 15
2013-07-15protein level
1 143 15
2013-06-11protein level
1 143 15
2013-02-12protein level
1 60 16
2012-12-20protein level
1 58 16
2012-10-30protein level
1 72 16
2012-10-07protein level
1 72 16
2012-08-24protein level
1 65 16
2012-07-28protein level
1 65 16
2012-06-08protein level
1 72 16
2012-05-07protein level
1 48 16
2012-04-10protein level
1 48 16
2012-01-13protein level
1 18 13
2011-12-20protein level
1 18 13
2011-11-11protein level
1 18 13
2011-08-23protein level
1 18 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43146-1
61 0 0 158356.8498
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1222919,EBI-358018 RPL5  
  .cellular protein metabolic process
.ribosomal large subunit biogenesis
.viral transcription
  + 10 more...
.poly(A) RNA binding
.5S rRNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.ribonucleoprotein complex
.cytosolic large ribosomal subunit
  + 6 more...
2 EBI-1222919,EBI-366357 RPL28  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cell body
.cytoplasmic ribonucleoprotein granule
  + 5 more...
3 EBI-1222919,EBI-1809742 MAZ  
  .positive regulation of transcription from RNA polymerase II promoter
.termination of RNA polymerase II transcription
.transcription initiation from RNA polymerase II promoter
.metal ion binding
.poly(A) RNA binding
.chromatin binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-1222919,EBI-353072 RPS23  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.structural constituent of ribosome
.cytosolic small ribosomal subunit
.membrane
.ribosome
  + 3 more...
5 EBI-1222919,EBI-307061 MYO10  
  .regulation of filopodium assembly
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.plus-end directed microfilament motor activity
.actin filament binding
.actin-dependent ATPase activity
  + 3 more...
.filopodium tip
.filopodium membrane
.lamellipodium
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
brain6
connective tissue33
ear124
embryonic tissue9
esophagus99
kidney4
lung11
testis66
thymus12
Health State
TissuesTPM*
normal8
esophageal tumor115
germ cell tumor11
kidney tumor14
lung tumor9
non-neoplasia20
primitive neuroectodermal tumor of the CNS15
soft tissue/muscle tissue tumor39
Developmental Stage
TissuesTPM*
adult5
embryoid body14
blastocyst16
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex2.4
lung4
testis19.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*120470, gene) Deleted in colorectal carcinoma; DCCOMIM
2(#157600, phenotype) Mirror movements 1; MRMV1OMIM


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