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> Protein (NX_P43246)
Protein (NX_P43246)
Protein
Gene SymbolMSH2 to neXtProt (NX_P43246)
DescriptionDNA mismatch repair protein Msh2
Chromosome2
Location2p21 (47630108 ~ 47789450) to Ensembl
Sequene Features : Isoforms 2, Variants 253, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of helicase activity
.negative regulation of DNA recombination
.isotype switching
  + 23 more...
.protein homodimerization activity
.guanine/thymine mispair binding
.protein kinase binding
  + 10 more...
.MutSbeta complex
.MutSalpha complex
.membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 253 8
2014-09-19protein level
2 245 8
2014-05-27protein level
2 245 8
2014-02-25protein level
2 243 7
2013-12-09protein level
2 218 7
2013-11-01protein level
2 201 2
2013-09-12protein level
2 201 1
2013-08-17protein level
2 201 1
2013-07-15protein level
2 184 1
2013-06-11protein level
2 184 1
2013-02-12protein level
1 164 3
2012-12-20protein level
1 165 3
2012-10-30protein level
1 164 3
2012-10-07protein level
1 159 3
2012-08-24protein level
1 159 3
2012-07-28protein level
1 159 3
2012-06-08protein level
1 148 3
2012-05-07protein level
1 147 3
2012-04-10protein level
1 147 3
2012-01-13protein level
1 169 3
2011-12-20protein level
1 169 3
2011-11-11protein level
1 169 3
2011-08-23protein level
1 169 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43246-1
4 40 0 104676.3979
NX_P43246-2
0 40 0 97260.6284
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355888,EBI-765551 E2F3  
  .negative regulation of fat cell proliferation
.positive regulation of transcription, DNA-templated
.positive regulation of cell proliferation
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.core promoter binding
.intracellular membrane-bounded organelle
.Golgi apparatus
.cytoplasm
  + 3 more...
2 EBI-355888,EBI-1164205 MSH3  
  .positive regulation of helicase activity
.negative regulation of DNA recombination
.maintenance of DNA repeat elements
  + 5 more...
.enzyme binding
.centromeric DNA binding
.DNA-dependent ATPase activity
  + 5 more...
.MutSbeta complex
.membrane
.nucleoplasm
  + 2 more...
3 EBI-355888,EBI-395529 MSH6  
  .intrinsic apoptotic signaling pathway
.positive regulation of helicase activity
.negative regulation of DNA recombination
  + 11 more...
.methylated histone binding
.guanine/thymine mispair binding
.mismatched DNA binding
  + 4 more...
.intracellular membrane-bounded organelle
.MutSalpha complex
.plasma membrane
  + 5 more...
4 EBI-355888,EBI-2370740 SLX4  
  .response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
5 EBI-355888,EBI-944694 EXO1  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.nucleic acid phosphodiester bond hydrolysis
.meiotic cell cycle
  + 6 more...
.double-stranded DNA 5'-3' exodeoxyribonuclease activity
.flap endonuclease activity
.metal ion binding
  + 7 more...
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
blood32
bone13
bone marrow41
brain55
cervix20
connective tissue33
ear62
embryonic tissue197
esophagus99
eye52
heart11
intestine47
kidney52
liver77
lung17
lymph67
lymph node100
mammary gland13
mouth60
muscle28
ovary19
pancreas18
parathyroid48
pharynx24
pituitary gland60
placenta17
prostate5
skin56
spleen18
stomach52
testis179
thymus225
tonsil117
trachea57
uterus21
vascular77
Health State
TissuesTPM*
normal54
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma36
colorectal tumor79
esophageal tumor115
gastrointestinal tumor59
germ cell tumor239
head and neck tumor29
kidney tumor43
leukemia42
liver tumor156
lung tumor9
lymphoma41
non-neoplasia51
ovarian tumor13
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma150
skin tumor71
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult50
embryoid body85
blastocyst390
neonate32
fetus75
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.6
adrenal gland8.8
appendix14.8
bone marrow11
cerebral cortex15.3
colon13.4
duodenum7.7
esophagus10.8
gallbladder7.2
heart muscle8.6
kidney8
liver4.7
lung8.8
lymph node24.6
ovary9.4
pancreas2.8
placenta10.1
prostate8.3
salivary gland6.8
skin10.3
small intestine9.8
spleen10.5
stomach9.3
testis19
thyroid gland18.4
urinary bladder11.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandLow
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#120435, phenotype) Lynch syndrome iOMIM
2(#158320, phenotype) Muir-torre syndrome; MRTESOMIM
3(#608089, phenotype) Endometrial cancerOMIM
4(*609309, gene) Muts, e. coli, homolog of, 2; MSH2OMIM
5colorectal;endometrial;ovarian;Hereditary non-polyposis colorectal cancerCGP


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