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> Protein (NX_P43355)
Protein (NX_P43355)
Protein
Gene SymbolMAGEA1 to neXtProt (NX_P43355)
DescriptionMelanoma-associated antigen 1
ChromosomeX
LocationXq28 (152481522 ~ 152486115) to Ensembl
Sequene Features : Isoforms 1, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of Notch signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.histone deacetylase binding .plasma membrane
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 54 5
2014-09-19protein level
1 42 5
2014-05-27protein level
1 42 5
2014-02-25protein level
1 42 5
2013-12-09protein level
1 41 5
2013-11-01protein level
1 41 5
2013-09-12protein level
1 41 5
2013-08-17protein level
1 41 5
2013-07-15protein level
1 24 5
2013-06-11protein level
1 24 5
2013-02-12protein level
1 13 5
2012-12-20protein level
1 13 5
2012-10-30protein level
1 13 5
2012-10-07protein level
1 13 5
2012-08-24protein level
1 10 5
2012-07-28protein level
1 10 5
2012-06-08protein level
1 12 5
2012-05-07protein level
1 12 5
2012-04-10protein level
1 12 5
2012-01-13protein level
1 9 5
2011-12-20protein level
1 9 5
2011-11-11protein level
1 9 4
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43355-1
11 0 3 34320.2992
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740978,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
2 EBI-740978,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
3 EBI-740978,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
4 EBI-740978,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
5 EBI-740978,EBI-744483 EID3  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 4 more...
.identical protein binding .Smc5-Smc6 complex
.cytoplasm
.nucleoplasm
.chromosome, telomeric region
6 EBI-740978,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
7 EBI-740978,EBI-747544 TRIM31  
  .regulation of viral release from host cell
.interferon-gamma-mediated signaling pathway
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 5 more...
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
8 EBI-740978,EBI-721615 RAB17  
  .regulation of synapse assembly
.regulation of filopodium assembly
.regulation of dendrite development
  + 11 more...
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.recycling endosome membrane
.recycling endosome
  + 9 more...
9 EBI-740978,EBI-740987 MIEF1  
  .positive regulation of protein targeting to membrane
.positive regulation of mitochondrial fission
.mitochondrial fission
.ADP binding
.identical protein binding
.GDP binding
.integral component of membrane
.mitochondrial outer membrane
.mitochondrion
10 EBI-740978,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
11 EBI-740978,EBI-1048743 HYPK  
  .N/A .N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
connective tissue6
lung14
mammary gland19
ovary9
skin14
testis4
Health State
TissuesTPM*
breast (mammary gland) tumor32
chondrosarcoma24
lung tumor48
skin tumor23
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
testis5
Tissues
TissuesExpression level
cerebral cortexLow
gallbladderLow
hippocampusLow
kidneyLow
lateral ventricleLow
soft tissue 1Low
soft tissue 2Low
testisHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300016, gene) Melanoma antigen, family a, 1; MAGEA1OMIM


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