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> Protein (NX_P43356)
Protein (NX_P43356)
Protein
Gene SymbolMAGEA2B to neXtProt (NX_P43356)
DescriptionMelanoma-associated antigen 2
ChromosomeX
LocationXq28 (151883082 ~ 151887096) to Ensembl
Sequene Features : Isoforms 1, Variants 0, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein acetylation
.cellular senescence
.signal transduction by p53 class mediator
  + 5 more...
.repressing transcription factor binding
.histone deacetylase binding
.ubiquitin protein ligase binding
.PML body
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 0 1
2014-09-19protein level
1 1 1
2014-05-27protein level
1 1 1
2014-02-25protein level
1 1 1
2013-12-09protein level
1 1 1
2013-11-01protein level
1 1 1
2013-09-12protein level
1 1 1
2013-08-17protein level
1 1 1
2013-07-15protein level
1 0 1
2013-06-11protein level
1 0 1
2013-02-12protein level
1 0 1
2012-12-20protein level
1 0 1
2012-10-30protein level
1 0 1
2012-10-07protein level
1 0 1
2012-08-24protein level
1 0 1
2012-07-28protein level
1 0 1
2012-06-08protein level
1 5 1
2012-05-07protein level
1 5 1
2012-04-10protein level
1 3 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 0
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43356-1
11 0 4 35032.5041
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5650739,EBI-607682 HDAC3  
  .cellular response to fluid shear stress
.spindle assembly
.neurotrophin TRK receptor signaling pathway
  + 21 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.transcriptional repressor complex
.plasma membrane
.spindle microtubule
  + 5 more...
2 EBI-5650739,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-5650739,EBI-2129909 UBE2H  
  .protein K11-linked ubiquitination
.protein K48-linked ubiquitination
.ubiquitin-dependent protein catabolic process
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 3 more...
.cytoplasm
4 EBI-5650739,EBI-78139 TRIM28  
  .regulation of genetic imprinting
.negative regulation of viral release from host cell
.negative regulation of DNA demethylation
  + 18 more...
.chromo shadow domain binding
.poly(A) RNA binding
.sequence-specific DNA binding
  + 10 more...
.RNA polymerase II transcription factor complex
.nuclear heterochromatin
.nuclear euchromatin
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
bone27
bone marrow20
connective tissue6
embryonic tissue14
esophagus49
mammary gland33
muscle9
pancreas4
placenta17
prostate31
skin4
stomach10
testis4
Health State
TissuesTPM*
normal3
adrenal tumor237
breast (mammary gland) tumor53
chondrosarcoma24
esophageal tumor57
germ cell tumor18
leukemia10
pancreatic tumor9
prostate cancer57
skin tumor15
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult9
blastocyst48
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
testis2.9
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*300173, gene) Melanoma antigen, family a, 2; MAGEA2OMIM
2(*300549, gene) Melanoma antigen, family a, 2b; MAGEA2BOMIM


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