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> Protein (NX_P43360)
Protein (NX_P43360)
Protein
Gene SymbolMAGEA6 to neXtProt (NX_P43360)
DescriptionMelanoma-associated antigen 6
ChromosomeX
LocationXq28 (151867214 ~ 151870825) to Ensembl
Sequene Features : Isoforms 1, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 76 0
2014-09-19protein level
1 52 0
2014-05-27protein level
1 52 0
2014-02-25protein level
1 52 0
2013-12-09protein level
1 50 0
2013-11-01protein level
1 49 0
2013-09-12protein level
1 49 0
2013-08-17protein level
1 49 0
2013-07-15protein level
1 41 0
2013-06-11protein level
1 41 0
2013-02-12protein level
1 20 0
2012-12-20protein level
1 20 0
2012-10-30protein level
1 21 0
2012-10-07protein level
1 21 0
2012-08-24protein level
1 19 0
2012-07-28protein level
1 19 0
2012-06-08protein level
1 17 0
2012-05-07protein level
1 17 0
2012-04-10protein level
1 17 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43360-1
6 0 7 34869.3259
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1045155,EBI-948905 ACOT7  
  .palmitic acid biosynthetic process
.medium-chain fatty acid biosynthetic process
.long-chain fatty-acyl-CoA catabolic process
  + 3 more...
.carboxylic ester hydrolase activity
.protein homodimerization activity
.long-chain fatty acyl-CoA binding
  + 2 more...
.extracellular exosome
.cell body
.neuron projection
  + 4 more...
2 EBI-1045155,EBI-707554 TXNDC9  
  .cell redox homeostasis .N/A .midbody
.centrosome
.cytoplasm
.nucleus
3 EBI-1045155,EBI-749204 BET1  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.N/A .Golgi cisterna
.integral component of membrane
.membrane
  + 3 more...
4 EBI-1045155,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
5 EBI-1045155,EBI-711802 ATP6V1G1  
  .phagosome maturation
.transmembrane transport
.interaction with host
  + 4 more...
.ATPase binding
.hydrogen-exporting ATPase activity, phosphorylative mechanism
.extracellular exosome
.vacuolar proton-transporting V-type ATPase complex
.plasma membrane
  + 2 more...
6 EBI-1045155,EBI-5357290 TULP3  
  .negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.ganglion development
.smoothened signaling pathway involved in dorsal/ventral neural tube patterning
  + 14 more...
.phosphatidylinositol binding
.protein complex binding
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
.ciliary base
.primary cilium
.axoneme
  + 5 more...
7 EBI-1045155,EBI-724909 SNX4  
  .positive regulation of histamine secretion by mast cell
.endocytic recycling
.vesicle organization
.protein transport
.leptin receptor binding
.transferrin receptor binding
.phosphatidylinositol binding
  + 2 more...
.protein complex
.early endosome membrane
.SNARE complex
  + 5 more...
8 EBI-1045155,EBI-356793 RPL37A  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.metal ion binding
.poly(A) RNA binding
.structural constituent of ribosome
.extracellular exosome
.cytosolic large ribosomal subunit
.focal adhesion
  + 2 more...
9 EBI-1045155,EBI-1642831 PDE4D  
  .negative regulation of relaxation of cardiac muscle
.regulation of cell communication by electrical coupling involved in cardiac conduction
.adrenergic receptor signaling pathway involved in positive regulation of heart rate
  + 29 more...
.scaffold protein binding
.ATPase binding
.metal ion binding
  + 8 more...
.calcium channel complex
.myofibril
.apical plasma membrane
  + 5 more...
10 EBI-1045155,EBI-714206 STX5  
  .regulation of Golgi organization
.Golgi disassembly
.vesicle fusion with Golgi apparatus
  + 7 more...
.protein N-terminus binding
.SNAP receptor activity
.SNARE binding
.endoplasmic reticulum-Golgi intermediate compartment membrane
.vesicle
.SNARE complex
  + 5 more...
11 EBI-1045155,EBI-78139 TRIM28  
  .regulation of genetic imprinting
.negative regulation of viral release from host cell
.negative regulation of DNA demethylation
  + 18 more...
.chromo shadow domain binding
.poly(A) RNA binding
.sequence-specific DNA binding
  + 10 more...
.RNA polymerase II transcription factor complex
.nuclear heterochromatin
.nuclear euchromatin
  + 2 more...
12 EBI-1045155,EBI-10238077 CTF1  
  .leukemia inhibitory factor signaling pathway
.neuron development
.positive regulation of tyrosine phosphorylation of Stat3 protein
  + 5 more...
.leukemia inhibitory factor receptor binding .extracellular space
.extracellular region
13 EBI-1045155,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
14 EBI-1045155,EBI-2866142 FAM214A  
  .N/A .N/A .N/A
15 EBI-1045155,EBI-10244848 SNAP47  
  .long-term synaptic potentiation
.synaptic vesicle fusion to presynaptic membrane
.synaptic vesicle priming
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.neuronal cell body
.SNARE complex
  + 3 more...
16 EBI-1045155,EBI-10245120 FRMPD1  
  .N/A .N/A .extracellular exosome
.plasma membrane
.cytoskeleton
.cytosol
17 EBI-1045155,EBI-10250923 ANKRD26P1  
  .N/A .N/A .N/A
18 EBI-1045155,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
19 EBI-1045155,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
20 EBI-1045155,EBI-7138654 LCORL  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.DNA binding .nucleus
21 EBI-1045155,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
22 EBI-1045155,EBI-10220600 IQUB  
  .cilium morphogenesis
.smoothened signaling pathway
.N/A .motile cilium
.acrosomal vesicle
23 EBI-1045155,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
24 EBI-1045155,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
25 EBI-1045155,EBI-10285740 ELMOD3  
  .phagocytosis .N/A .kinocilium
.stereocilium
.cytoskeleton
.cytoplasm
26 EBI-1045155,EBI-745021 STAMBPL1  
  .N/A .metal ion binding
.metallopeptidase activity
.membrane
27 EBI-1045155,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
28 EBI-1045155,EBI-9641546 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
29 EBI-1045155,EBI-2560588 BCL7B  
  .N/A .actin binding .N/A
30 EBI-1045155,EBI-2933362 RASSF4  
  .signal transduction
.cell cycle
.N/A .N/A
31 EBI-1045155,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
32 EBI-1045155,EBI-751842 S100A14  
  .positive regulation of monocyte chemotaxis
.positive regulation of granulocyte chemotaxis
.calcium ion homeostasis
  + 4 more...
.chemokine receptor binding
.calcium ion binding
.extracellular exosome
.perinuclear region of cytoplasm
.cell junction
  + 4 more...
33 EBI-1045155,EBI-8799578 GFOD1  
  .N/A .oxidoreductase activity .extracellular region
34 EBI-1045155,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
35 EBI-1045155,EBI-347416 LSM2  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.Ral GTPase binding
.U6 snRNA binding
.catalytic step 2 spliceosome
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
bone13
bone marrow41
brain5
cervix41
liver9
lung8
lymph22
lymph node33
mammary gland19
pancreas4
placenta84
prostate79
skin204
stomach52
testis13
Health State
TissuesTPM*
normal2
adrenal tumor316
breast (mammary gland) tumor21
chondrosarcoma12
gastrointestinal tumor67
germ cell tumor91
glioma9
leukemia21
liver tumor10
lung tumor29
lymphoma13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS55
prostate cancer144
skin tumor342
Developmental Stage
TissuesTPM*
adult12
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
testis8.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*300176, gene) Melanoma antigen, family a, 6; MAGEA6OMIM


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