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> Protein (NX_P43364)
Protein (NX_P43364)
Protein
Gene SymbolMAGEA11 to neXtProt (NX_P43364)
DescriptionMelanoma-associated antigen 11
ChromosomeX
LocationXq28 (148769894 ~ 148798926) to Ensembl
Sequene Features : Isoforms 2, Variants 93, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 93 1
2014-09-19protein level
2 66 1
2014-05-27protein level
2 66 1
2014-02-25protein level
2 42 1
2013-12-09protein level
2 39 1
2013-11-01protein level
2 39 1
2013-09-12protein level
2 39 1
2013-08-17protein level
2 39 1
2013-07-15protein level
2 35 1
2013-06-11protein level
2 35 1
2013-02-12protein level
2 13 2
2012-12-20protein level
2 9 2
2012-10-30protein level
2 9 2
2012-10-07protein level
2 9 1
2012-08-24protein level
2 11 1
2012-07-28protein level
2 11 1
2012-06-08protein level
2 8 1
2012-05-07protein level
2 8 1
2012-04-10protein level
2 8 1
2012-01-13protein level
2 5 1
2011-12-20protein level
2 5 1
2011-11-11protein level
2 5 1
2011-08-23protein level
2 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43364-1
2 17 0 48098.7348
NX_P43364-2
1 17 0 44247.7779
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10178634,EBI-526406 BCL2L11  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of fibroblast apoptotic process
.positive regulation of IRE1-mediated unfolded protein response
  + 42 more...
.N/A .BIM-BCL-2 complex
.BIM-BCL-xl complex
.extrinsic component of membrane
  + 3 more...
2 EBI-10178634,EBI-3893317 HOXB5  
  .embryonic skeletal system morphogenesis
.endothelial cell differentiation
.anterior/posterior pattern specification
.anatomical structure morphogenesis
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.nucleus
3 EBI-10178634,EBI-751694 IL11  
  .positive regulation of peptidyl-tyrosine phosphorylation
.negative regulation of hormone secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.growth factor activity
.interleukin-11 receptor binding
.cytoplasm
.extracellular space
.extracellular region
4 EBI-10178634,EBI-1391623 NOS3  
  .negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.phagosome maturation
.negative regulation of calcium ion transport
  + 34 more...
.NADP binding
.flavin adenine dinucleotide binding
.cadmium ion binding
  + 8 more...
.endocytic vesicle membrane
.caveola
.plasma membrane
  + 5 more...
5 EBI-10178634,EBI-749356 GNPDA1  
  .single fertilization
.generation of precursor metabolites and energy
.N-acetylglucosamine metabolic process
  + 2 more...
.hydrolase activity
.glucosamine-6-phosphate deaminase activity
.extracellular exosome
.cytoplasm
6 EBI-10178634,EBI-722932 STAR  
  .cellular response to epinephrine stimulus
.cellular response to transforming growth factor beta stimulus
.cellular response to dexamethasone stimulus
  + 52 more...
.cholesterol transporter activity
.cholesterol binding
.neuronal cell body
.neuron projection
.mitochondrial crista
  + 2 more...
7 EBI-10178634,EBI-347804 CSNK2A1  
  .mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
8 EBI-10178634,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
9 EBI-739552,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
10 EBI-10178634,EBI-10179508 ENOX2  
  .oxidation-reduction process
.regulation of growth
.cell growth
.ultradian rhythm
.protein disulfide oxidoreductase activity
.nucleic acid binding
.nucleotide binding
.external side of plasma membrane
.cytosol
.extracellular space
11 EBI-10178634,EBI-751035 CCDC14  
  .substantia nigra development .N/A .centrosome
12 EBI-10178634,EBI-747711 DIEXF  
  .multicellular organismal development
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding
.U3 snoRNA binding
.rRNA binding
.small-subunit processome
.nucleolus
13 EBI-10178634,EBI-748373 ZCCHC12  
  .BMP signaling pathway
.transcription, DNA-templated
.ligand-dependent nuclear receptor transcription coactivator activity
.zinc ion binding
.nucleic acid binding
.nuclear speck
14 EBI-10178634,EBI-744896 SNX20  
  .protein transport .phosphatidylinositol binding .endosome membrane
.plasma membrane
.nucleus
15 EBI-10178634,EBI-780319 RBM23  
  .mRNA processing .RNA binding
.nucleotide binding
.membrane
.nucleus
16 EBI-10178634,EBI-10260504 CDC20B  
  .N/A .N/A .N/A
17 EBI-10178634,EBI-10262451 DNAJC10  
  .intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.cell redox homeostasis
.response to endoplasmic reticulum stress
  + 4 more...
.misfolded protein binding
.ATPase binding
.chaperone binding
  + 5 more...
.endoplasmic reticulum chaperone complex
.membrane
.endoplasmic reticulum lumen
.endoplasmic reticulum
18 EBI-10178634,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
19 EBI-10178634,EBI-749248 TMEM123  
  .oncosis .receptor activity .integral component of membrane
.external side of plasma membrane
20 EBI-10178634,EBI-10264970 THEM5  
  .cardiolipin acyl-chain remodeling
.long-chain fatty-acyl-CoA metabolic process
.fatty acid metabolic process
.palmitoyl-CoA hydrolase activity .mitochondrial matrix
21 EBI-10178634,EBI-746368 PNKD  
  .neuromuscular process controlling posture
.regulation of dopamine metabolic process
.regulation of synaptic transmission, dopaminergic
.glutathione biosynthetic process
.zinc ion binding
.hydroxyacylglutathione hydrolase activity
.membrane
.mitochondrion
.nucleus
22 EBI-10178634,EBI-749859 ACMSD  
  .quinolinate metabolic process
.small molecule metabolic process
.cellular nitrogen compound metabolic process
.tryptophan catabolic process
.metal ion binding
.aminocarboxymuconate-semialdehyde decarboxylase activity
.extracellular exosome
.cytosol
23 EBI-10178634,EBI-10278909 JADE3  
  .histone H4-K12 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
.histone H3 acetylation
.zinc ion binding .histone acetyltransferase complex
24 EBI-10178634,EBI-739780 CLUAP1  
  .cilium assembly
.organelle organization
.N/A .ciliary tip
.primary cilium
.intracellular membrane-bounded organelle
  + 4 more...
25 EBI-10178634,EBI-10282566 DOCK10  
  .regulation of cell migration
.small GTPase mediated signal transduction
.Rho guanyl-nucleotide exchange factor activity .extracellular exosome
.membrane
26 EBI-10178634,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
27 EBI-10178634,EBI-744267 RADIL  
  .substrate adhesion-dependent cell spreading
.multicellular organismal development
.signal transduction
.N/A .microtubule
28 EBI-10178634,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
29 EBI-10178634,EBI-745182 TCF25  
  .heart development
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
30 EBI-10178634,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
31 EBI-10178634,EBI-634289 PCBD2  
  .protein heterooligomerization
.protein homotetramerization
.positive regulation of transcription, DNA-templated
.tetrahydrobiopterin biosynthetic process
.4-alpha-hydroxytetrahydrobiopterin dehydratase activity
.phenylalanine 4-monooxygenase activity
.mitochondrion
.nucleus
32 EBI-739552,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
33 EBI-10178634,EBI-748900 TRMT1  
  .tRNA N2-guanine methylation .metal ion binding
.poly(A) RNA binding
.tRNA (guanine-N2-)-methyltransferase activity
.tRNA binding
.mitochondrion
.nucleus
34 EBI-10178634,EBI-714599 PIN4  
  .rRNA processing .poly(A) RNA binding
.peptidyl-prolyl cis-trans isomerase activity
.double-stranded DNA binding
  + 2 more...
.extracellular exosome
.preribosome
.spindle
  + 4 more...
35 EBI-10178634,EBI-2511991 USP20  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 4 more...
.zinc ion binding
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.G-protein coupled receptor binding
.perinuclear region of cytoplasm
.centrosome
36 EBI-10178634,EBI-713654 NDUFB9  
  .activation of mitophagy in response to mitochondrial depolarization
.small molecule metabolic process
.cellular metabolic process
  + 3 more...
.NADH dehydrogenase (ubiquinone) activity .extracellular exosome
.mitochondrial respiratory chain complex I
.mitochondrial inner membrane
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone55
connective tissue6
esophagus99
liver4
placenta60
skin18
testis9
uterus25
Health State
TissuesTPM*
normal5
chondrosarcoma48
esophageal tumor115
germ cell tumor3
liver tumor10
skin tumor31
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult11
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
placenta2.5
testis4.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300344, gene) Melanoma antigen, family a, 11; MAGEA11OMIM


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2014-2019 (C) Yonsei Proteome Research Center