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> Protein (NX_P43378)
Protein (NX_P43378)
Protein
Gene SymbolPTPN9 to neXtProt (NX_P43378)
DescriptionTyrosine-protein phosphatase non-receptor type 9
Chromosome15
Location15q24.2 (75759462 ~ 75871630) to Ensembl
Sequene Features : Isoforms 1, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 60 2
2014-09-19protein level
1 46 2
2014-05-27protein level
1 46 2
2014-02-25protein level
1 45 2
2013-12-09protein level
1 34 2
2013-11-01protein level
1 33 1
2013-09-12protein level
1 33 1
2013-08-17protein level
1 33 1
2013-07-15protein level
1 22 0
2013-06-11protein level
1 22 0
2013-02-12protein level
1 8 1
2012-12-20protein level
1 10 1
2012-10-30protein level
1 12 1
2012-10-07protein level
1 12 1
2012-08-24protein level
1 8 1
2012-07-28protein level
1 8 1
2012-06-08protein level
1 8 1
2012-05-07protein level
1 8 1
2012-04-10protein level
1 8 1
2012-01-13protein level
1 5 1
2011-12-20protein level
1 5 1
2011-11-11protein level
1 5 1
2011-08-23protein level
1 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43378-1
31 0 0 67976.6461
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742898,EBI-740467 RTN3  
  .endoplasmic reticulum tubular network organization
.vesicle-mediated transport
.viral process
.apoptotic process
.N/A .extracellular exosome
.integral component of membrane
.endoplasmic reticulum membrane
  + 3 more...
2 EBI-742898,EBI-286316 GHR  
  .JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.positive regulation of peptidyl-tyrosine phosphorylation
  + 25 more...
.proline-rich region binding
.protein homodimerization activity
.protein kinase binding
  + 3 more...
.growth hormone receptor complex
.receptor complex
.integral component of membrane
  + 5 more...
3 EBI-742898,EBI-712251 NSF  
  .Golgi vesicle docking
.ATP metabolic process
.positive regulation of protein catabolic process
  + 10 more...
.metal ion binding
.ATPase activity, coupled
.protein complex binding
  + 6 more...
.extracellular exosome
.dendritic shaft
.postsynaptic density
  + 5 more...
4 EBI-742898,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
5 EBI-742898,EBI-944295 MAL2  
  .N/A .N/A .extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 3 more...
6 EBI-742898,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
blood32
bone41
brain27
connective tissue40
embryonic tissue32
esophagus49
eye9
heart44
intestine64
kidney37
larynx85
liver4
lung89
lymph node22
mammary gland13
mouth15
muscle28
ovary49
pancreas23
parathyroid48
pharynx24
pituitary gland121
placenta42
prostate52
salivary gland296
skin14
spleen18
stomach10
testis11
thymus75
thyroid64
umbilical cord72
uterus47
vascular19
Health State
TissuesTPM*
normal34
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma36
colorectal tumor97
esophageal tumor57
gastrointestinal tumor25
germ cell tumor30
glioma93
head and neck tumor37
kidney tumor14
leukemia21
liver tumor10
lung tumor38
non-neoplasia20
ovarian tumor52
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
prostate cancer48
skin tumor15
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult45
embryoid body42
blastocyst32
neonate64
fetus68
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.5
adrenal gland11.4
appendix13.1
bone marrow7
cerebral cortex11.4
colon17.9
duodenum16
esophagus9.8
gallbladder14.2
heart muscle7.8
kidney14.5
liver7.4
lung14
lymph node14.2
ovary13.6
pancreas5.3
placenta16.8
prostate13.8
salivary gland7.8
skin6.1
small intestine19.1
spleen13.6
stomach12.6
testis8.9
thyroid gland32.8
urinary bladder16
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusLow
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleLow
liverHigh
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaLow
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleLow
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600768, gene) Protein-tyrosine phosphatase, nonreceptor-type, 9; PTPN9OMIM


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