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> Protein (NX_P43403)
Protein (NX_P43403)
Protein
Gene SymbolZAP70 to neXtProt (NX_P43403)
DescriptionTyrosine-protein kinase ZAP-70
Chromosome2
Location2q11.2 (98330023 ~ 98356325) to Ensembl
Sequene Features : Isoforms 3, Variants 107, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.T cell migration
.T cell aggregation
.T cell receptor signaling pathway
  + 19 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.T cell receptor complex
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 107 23
2014-09-19protein level
3 76 23
2014-05-27protein level
3 76 23
2014-02-25protein level
3 75 23
2013-12-09protein level
3 59 23
2013-11-01protein level
3 56 23
2013-09-12protein level
3 56 23
2013-08-17protein level
3 56 23
2013-07-15protein level
3 42 7
2013-06-11protein level
3 42 7
2013-02-12protein level
3 22 21
2012-12-20protein level
3 22 21
2012-10-30protein level
3 21 21
2012-10-07protein level
3 21 8
2012-08-24protein level
3 21 8
2012-07-28protein level
3 21 8
2012-06-08protein level
3 39 8
2012-05-07protein level
3 31 8
2012-04-10protein level
3 31 8
2012-01-13protein level
3 43 8
2011-12-20protein level
3 30 8
2011-11-11protein level
3 30 8
2011-08-23protein level
3 24 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43403-1
10 24 1 69826.7925
NX_P43403-2
1 13 1 35623.6295
NX_P43403-3
1 24 1 55836.9651
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1211276,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-1211276,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
3 EBI-1211276,EBI-1211297 CD3E  
  .apoptotic signaling pathway
.T cell receptor signaling pathway
.positive regulation of calcium-mediated signaling
  + 20 more...
.protein heterodimerization activity
.T cell receptor binding
.receptor signaling complex scaffold activity
  + 4 more...
.alpha-beta T cell receptor complex
.T cell receptor complex
.external side of plasma membrane
  + 4 more...
4 EBI-1211276,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
5 EBI-1211276,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
6 EBI-1211276,EBI-1165705 CD247  
  .T cell receptor signaling pathway
.regulation of immune response
.regulation of defense response to virus by virus
  + 4 more...
.protein homodimerization activity
.identical protein binding
.transmembrane signaling receptor activity
.alpha-beta T cell receptor complex
.T cell receptor complex
.integral component of membrane
  + 2 more...
7 EBI-1211276,EBI-1211241 PTPN22  
  .negative regulation of T cell activation
.negative regulation of T cell receptor signaling pathway
.regulation of B cell receptor signaling pathway
  + 7 more...
.kinase binding
.SH3 domain binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood122
bone marrow41
eye4
intestine8
kidney4
liver14
lymph node77
mammary gland6
muscle18
prostate5
spleen18
thymus376
uterus4
Health State
TissuesTPM*
normal14
breast (mammary gland) tumor10
germ cell tumor22
leukemia137
retinoblastoma21
uterine tumor11
Developmental Stage
TissuesTPM*
adult17
fetus8
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.9
adrenal gland2.3
appendix47.3
bone marrow35.8
colon4.1
duodenum7.9
esophagus2.2
gallbladder10.6
heart muscle1.8
kidney1.4
liver2.2
lung13.8
lymph node92.7
ovary1.2
pancreas1.2
placenta1.3
prostate3.1
salivary gland4
skin3.3
small intestine12.1
spleen51
stomach11.1
testis3.3
thyroid gland1.5
urinary bladder13.9
Tissues
TissuesExpression level
appendixHigh
bone marrowMedium
lymph nodeHigh
spleenMedium
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176947, gene) Zeta-chain-associated protein kinase; ZAP70OMIM
2(#269840, phenotype) Selective t-cell defect; STCDOMIM


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