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> Protein (NX_P43405)
Protein (NX_P43405)
Protein
Gene SymbolSYK to neXtProt (NX_P43405)
DescriptionTyrosine-protein kinase SYK
Chromosome9
Location9q22.2 (93564069 ~ 93660831) to Ensembl
Sequene Features : Isoforms 2, Variants 95, PTMs 32 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 95 32
2014-09-19protein level
2 69 32
2014-05-27protein level
2 69 32
2014-02-25protein level
2 66 32
2013-12-09protein level
2 54 32
2013-11-01protein level
2 47 31
2013-09-12protein level
2 47 31
2013-08-17protein level
2 47 31
2013-07-15protein level
2 32 31
2013-06-11protein level
2 32 31
2013-02-12protein level
2 13 59
2012-12-20protein level
2 13 59
2012-10-30protein level
2 11 59
2012-10-07protein level
2 11 31
2012-08-24protein level
2 9 31
2012-07-28protein level
2 9 31
2012-06-08protein level
2 14 31
2012-05-07protein level
2 9 31
2012-04-10protein level
2 9 31
2012-01-13protein level
2 10 31
2011-12-20protein level
2 9 31
2011-11-11protein level
2 9 31
2011-08-23protein level
2 8 31
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43405-1
3 29 1 72020.0819
NX_P43405-2
1 29 1 69465.6974
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-78302,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-78302,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-78302,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
4 EBI-78302,EBI-1211297 CD3E  
  .apoptotic signaling pathway
.T cell receptor signaling pathway
.positive regulation of calcium-mediated signaling
  + 20 more...
.protein heterodimerization activity
.T cell receptor binding
.receptor signaling complex scaffold activity
  + 4 more...
.alpha-beta T cell receptor complex
.T cell receptor complex
.external side of plasma membrane
  + 4 more...
5 EBI-78302,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
6 EBI-78302,EBI-6139068 CD37  
  .regulation of defense response to virus
.defense response to protozoan
.negative regulation of myeloid dendritic cell activation
  + 3 more...
.N/A .extracellular exosome
.integral component of membrane
.membrane
.immunological synapse
7 EBI-78302,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
8 EBI-78302,EBI-78277 CD22  
  .cell adhesion .carbohydrate binding .extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
9 EBI-78302,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
10 EBI-78302,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
11 EBI-78302,EBI-515289 FCER1G  
  .protein localization to plasma membrane
.leukocyte migration
.positive regulation of phagocytosis
  + 26 more...
.IgE receptor activity .Fc-epsilon receptor I complex
.cell surface
.external side of plasma membrane
  + 2 more...
12 EBI-78302,EBI-3946257 FLT3  
  .dendritic cell differentiation
.cellular response to glucocorticoid stimulus
.cellular response to cytokine stimulus
  + 24 more...
.protein homodimerization activity
.ATP binding
.vascular endothelial growth factor-activated receptor activity
  + 2 more...
.protein complex
.external side of plasma membrane
.integral component of plasma membrane
  + 3 more...
13 EBI-78302,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
14 EBI-78302,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
15 EBI-78302,EBI-1380492 UBASH3B  
  .negative regulation of platelet aggregation
.regulation of release of sequestered calcium ion into cytosol
.negative regulation of protein kinase activity
.protein tyrosine phosphatase activity .cytoplasm
.nucleus
16 EBI-78302,EBI-954084 FAM46A  
  .regulation of blood coagulation
.regulation of gene expression
.poly(A) RNA binding .N/A
17 EBI-78302,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
18 EBI-78302,EBI-2513462 USP25  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 3 more...
.SUMO binding
.peptidase activity
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites125
bladder33
blood196
bone27
bone marrow184
brain12
cervix20
connective tissue46
eye47
intestine68
kidney52
liver53
lung95
lymph248
lymph node534
mammary gland39
mouth120
muscle18
nerve64
ovary177
pancreas4
parathyroid485
pharynx24
placenta38
prostate5
skin4
spleen93
stomach20
testis16
thymus125
thyroid42
tonsil646
uterus38
Health State
TissuesTPM*
normal48
bladder carcinoma113
breast (mammary gland) tumor32
chondrosarcoma48
colorectal tumor79
gastrointestinal tumor59
germ cell tumor60
glioma74
head and neck tumor52
kidney tumor29
leukemia201
liver tumor20
lung tumor107
lymphoma290
non-neoplasia51
ovarian tumor223
pancreatic tumor9
prostate cancer9
retinoblastoma129
uterine tumor55
Developmental Stage
TissuesTPM*
adult62
fetus32
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.6
adrenal gland4.8
appendix42.4
bone marrow28.7
cerebral cortex3.6
colon20.9
duodenum28.2
esophagus18.5
gallbladder14.5
heart muscle2.4
kidney12.6
liver2.4
lung16.1
lymph node60.7
ovary1.6
pancreas4.9
placenta10.5
prostate3.2
salivary gland7.7
skin8.7
small intestine34.6
spleen36.1
stomach20.8
testis8.7
thyroid gland28.3
urinary bladder21.7
Tissues
TissuesExpression level
appendixHigh
bone marrowHigh
breastLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungHigh
lymph nodeHigh
nasopharynxLow
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
rectumHigh
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600085, gene) Protein-tyrosine kinase syk; SYKOMIM
2myelodysplastic syndrome;peripheral T-cell lymphomaCGP


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